ECH1 and EEF1D

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ECH1	EEF1D
Description		enoyl-CoA hydratase 1	eukaryotic translation elongation factor 1 delta
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Membrane Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Catalytic Activity Protein Binding Isomerase Activity Delta(3,5)-delta(2,4)-dienoyl-CoA Isomerase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding Heat Shock Protein Binding Cadherin Binding DNA-binding Transcription Factor Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation	Cytoplasmic Translational Elongation Translation Translational Elongation Cellular Response To Heat Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Ionizing Radiation
Pathways		Peroxisomal protein import Peroxisomal protein import Mitochondrial protein degradation	Eukaryotic Translation Elongation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)	Schizophrenia ( 31268507)
Interacting Genes		13 interacting genes: APP CSTF2 EEF1D EEF1G FAM9B FXR1 FXR2 HTT PAFAH1B3 SERPINB9 STAT3 TIMP1 TLR10	45 interacting genes: ALX1 APP ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CDK9 CEBPA CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS1 FILNC1 FKBP6 FOS FRA10AC1 GARS1 HEXD KARS1 KTN1 LINC01232 MAP1B NR2F1 POT1 PRKCA RELA RNF20 RNF40 RPS6KA1 SIAH1 SIAH2 SLC26A4-AS1 SNCA TERF1 TINF2 TPT1 UBE2A USP40 USP7 VARS1
Entrez ID		1891	1936
HPRD ID		02825	00560
Ensembl ID		ENSG00000104823	ENSG00000104529
Uniprot IDs		A0A384MR44 Q13011	B2RAR6 P29692
PDB IDs		2VRE 8SK6	2MVM 2MVN 2N51 5JPO
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Endopeptidase Activity Positive Regulation Of Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Peptidase Inhibitor Activity Translation Elongation Factor Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Positive Regulation Of MRNA Catabolic Process Translation Regulator Activity Protein Heterodimerization Activity Protein Homodimerization Activity Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of MRNA Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Dentate Gyrus Development Regulation Of Post-transcriptional Gene Silencing Regulation Of Defense Response Regulation Of Tumor Necrosis Factor Production Modulation Of Chemical Synaptic Transmission Positive Regulation Of ATP Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of MRNA Stability Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Regulation Of Long-term Synaptic Potentiation Cellular Response To Nerve Growth Factor Stimulus Regulation Of RNA Stability Response To Nerve Growth Factor Amyloid-beta Complex Presynapse Growth Cone Lamellipodium Postsynapse Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Calcium-mediated Signaling MRNA Binding Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Interleukin-1 Beta Production Translational Elongation Regulation Of Carbohydrate Catabolic Process Platelet Alpha Granule Lumen Identical Protein Binding Heat Shock Protein Binding Regulation Of Multicellular Organism Growth	Protein Metabolic Process Shelterin Complex HULC Complex Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Amyloid Fibril Formation Negative Regulation Of Biosynthetic Process Nuclear Telomere Cap Complex Positive Regulation Of Metabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Telomere Capping TRNA Aminoacylation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Nucleic Acid Metabolic Process Diadenosine Tetraphosphate Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Macromolecule Biosynthetic Process White Fat Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Chromatin Binding Nucleobase-containing Compound Metabolic Process Regulation Of Schwann Cell Differentiation Telomere Assembly Chromatin Organization Regulation Of Protein Catabolic Process Telomeric DNA Binding Nucleus Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Interleukin-1 Regulation Of Synapse Assembly Cytosol Negative Regulation Of DNA Biosynthetic Process Response To Cytokine Regulation Of Macromolecule Biosynthetic Process Response To Copper Ion Response To Peptide Regulation Of Establishment Of Protein Localization To Telomere DNA Metabolic Process DNA-binding Transcription Factor Binding Response To Xenobiotic Stimulus Nucleoplasm Regulation Of Primary Metabolic Process Ankyrin Repeat Binding
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