ECH1 and TIMP1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		ECH1	TIMP1
Description		enoyl-CoA hydratase 1	TIMP metallopeptidase inhibitor 1
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Membrane Extracellular Exosome	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Secretory Granule Lumen Extracellular Exosome
	Molecular Function	Catalytic Activity Protein Binding Isomerase Activity Delta(3,5)-delta(2,4)-dienoyl-CoA Isomerase Activity	Protease Binding Enzyme Inhibitor Activity Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation	Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Response To Cytokine Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Peptide Hormone Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cartilage Development Cellular Response To UV-A Negative Regulation Of Trophoblast Cell Migration Cellular Response To Peptide Negative Regulation Of Metallopeptidase Activity Regulation Of Integrin-mediated Signaling Pathway
Pathways		Peroxisomal protein import Peroxisomal protein import Mitochondrial protein degradation	Platelet degranulation Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation TGFBR3 PTM regulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)
Interacting Genes		13 interacting genes: APP CSTF2 EEF1D EEF1G FAM9B FXR1 FXR2 HTT PAFAH1B3 SERPINB9 STAT3 TIMP1 TLR10	9 interacting genes: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5 UBC
Entrez ID		1891	7076
HPRD ID		02825	02371
Ensembl ID		ENSG00000104823	ENSG00000102265
Uniprot IDs		A0A384MR44 Q13011	P01033 Q6FGX5
PDB IDs		2VRE 8SK6	1D2B 1OO9 1UEA 2J0T 3MA2 3V96 6MAV 6N9D 7S7L 7S7M
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Endopeptidase Activity Positive Regulation Of Catabolic Process Negative Regulation Of Long-term Synaptic Potentiation Peptidase Inhibitor Activity Translation Elongation Factor Activity Negative Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Positive Regulation Of MRNA Catabolic Process Translation Regulator Activity Protein Heterodimerization Activity Protein Homodimerization Activity Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of MRNA Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Dentate Gyrus Development Regulation Of Post-transcriptional Gene Silencing Regulation Of Defense Response Regulation Of Tumor Necrosis Factor Production Modulation Of Chemical Synaptic Transmission Positive Regulation Of ATP Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of MRNA Stability Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Plasticity Regulation Of Long-term Synaptic Potentiation Cellular Response To Nerve Growth Factor Stimulus Regulation Of RNA Stability Response To Nerve Growth Factor Amyloid-beta Complex Presynapse Growth Cone Lamellipodium Postsynapse Regulation Of Response To Calcium Ion Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Calcium-mediated Signaling MRNA Binding Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Interleukin-1 Beta Production Translational Elongation Regulation Of Carbohydrate Catabolic Process Platelet Alpha Granule Lumen Identical Protein Binding Heat Shock Protein Binding Regulation Of Multicellular Organism Growth	Cellular Response To UV-A Response To UV-A Collagen Catabolic Process Extracellular Matrix Disassembly Collagen Metabolic Process Metalloendopeptidase Activity Endopeptidase Activity Cellular Response To UV Cellular Response To Light Stimulus Metallopeptidase Activity Serine-type Endopeptidase Activity Response To UV Cellular Response To Radiation Fibronectin Binding Extracellular Structure Organization Extracellular Matrix Organization Pigment Granule Maturation Extracellular Space Delta(3,5)-delta(2,4)-dienoyl-CoA Isomerase Activity Response To Light Stimulus Response To Amyloid-beta Skeletal Muscle Hypertrophy Mitochondrion Cellular Response To Amino Acid Stimulus Regulation Of Cell Migration Mitotic DNA-templated DNA Replication Extracellular Matrix Regulation Of Cell Motility Response To Radiation Peptidase Activity Cellular Pigment Accumulation Regulation Of Locomotion Catabolic Process Cellular Response To Reactive Oxygen Species Mitotic DNA Replication Response To Amino Acid Positive Regulation Of Cellular Component Organization Cellular Pigmentation Eukaryotic Translation Elongation Factor 1 Complex Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Catalytic Activity, Acting On DNA Proteolysis Extracellular Region Multivesicular Body, Internal Vesicle Isomerase Activity Clustering Of Voltage-gated Sodium Channels Cellular Response To Camptothecin Platelet Dense Granule Membrane Intramembranous Ossification
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