ECH1 and HTT

Number of citations of the paper that reports this interaction (PMID 15383276)
99

Data Source:
BioGRID (pull down, two hybrid)

		ECH1	HTT
Gene Name		enoyl CoA hydratase 1, peroxisomal	huntingtin
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Peroxisome Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Mitochondrion Late Endosome Autophagic Vacuole Endoplasmic Reticulum Golgi Apparatus Cytosol Inclusion Body Axon Dendrite Cytoplasmic Vesicle Membrane Protein Complex
	Molecular Function	Receptor Binding Protein Binding Isomerase Activity	P53 Binding Protein Binding Transcription Factor Binding Dynactin Binding Identical Protein Binding Ion Channel Binding Dynein Intermediate Chain Binding Beta-tubulin Binding Diazepam Binding
	Biological Process	Fatty Acid Beta-oxidation	Urea Cycle Citrulline Metabolic Process Establishment Of Mitotic Spindle Orientation Protein Import Into Nucleus ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Endoplasmic Reticulum Organization Golgi Organization Dopamine Receptor Signaling Pathway Spermatogenesis Cell Aging Grooming Behavior Locomotory Behavior Axon Cargo Transport Determination Of Adult Lifespan Visual Learning Anterior/posterior Pattern Specification Endosomal Transport Lactate Biosynthetic Process From Pyruvate Quinolinate Biosynthetic Process Striatum Development Olfactory Lobe Development Neural Plate Formation Insulin Secretion Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Phosphatase Type 2A Activity Social Behavior Hormone Metabolic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Mitochondrial Membrane Permeability Vesicle Transport Along Microtubule Regulation Of Synaptic Plasticity Paraxial Mesoderm Formation Organ Development Neuron Development Neuron Apoptotic Process Response To Calcium Ion Regulation Of Mitochondrial Membrane Potential L-glutamate Import Iron Ion Homeostasis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: APP CSTF2 EEF1D EEF1G FAM9B HTT PAFAH1B3 PEX5 SERPINB9 STAT3 TIMP1 TLR10 TRAF1	108 interactors: AKT1 AMFR AP2A2 CASP1 CASP3 CASP6 CBS CHD3 CHUK CREBBP CRMP1 CTBP1 DLG4 DNALI1 DPPA4 DUSP10 ECH1 EGFR ERCC6L ETV4 EVL F8A1 FEZ1 FICD FTL GAPDH GGA2 GIT1 GOLPH3L GPRASP2 GRB2 HAP1 HEYL HIP1 HIP1R HIST1H3H HOXC11 HOXC4 HSPA8 HYPK HYPM IFT20 IKBKAP IKBKB IKBKG ING5 KAT2B KIAA1377 MAGEA3 MAGEB18 MAGEB6 MAP3K10 MBD1 MED21 MED31 MID1 MRFAP1 MRFAP1L1 MTSS1 NCOR1 NUPL1 OPTN OSTF1 PACSIN1 PDK2 PEX11B PFN2 PIAS1 PIAS4 PIK3R1 PML PPP2CA PRPF40A PRPF40B PSMC5 RASA1 REST RNF20 RPS6KB1 SAP30 SETD2 SH3GL3 SH3GLB1 SIN3A SP1 SUMO1 SYMPK TACC1 TAF4 TBP TCERG1 TGM2 TP53 TPR TRAFD1 TRIP10 TTC23 TUBB UBAC1 UBE2E3 UBE2K UTP14A VCP XRCC6 ZDHHC17 ZFYVE19 ZNF451 ZNF655
Entrez ID		1891	3064
HPRD ID		02825	00883
Ensembl ID		ENSG00000104823	ENSG00000197386
Uniprot IDs		Q13011	P42858
PDB IDs		2VRE	2D3X 2LD0 2LD2 3IO4 3IO6 3IOR 3IOT 3IOU 3IOV 3IOW 3LRH 4FE8 4FEB 4FEC 4FED
Enriched GO Terms of Interacting Partners?		Regulation Of Developmental Growth Regulation Of Multicellular Organism Growth Protein Import Central Nervous System Development MRNA Polyadenylation Response To Estrogen RNA Polyadenylation Regulation Of Growth Endoplasmic Reticulum Organization Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Axon Cargo Transport Mating Negative Regulation Of Neurogenesis Mitochondrial Membrane Organization Neuron Apoptotic Process Brain Development Visual Learning Sexual Reproduction Head Development Visual Behavior Neuron Death Neural Plate Formation Negative Regulation Of Cell Development Platelet Degranulation Regulation Of Cell Death Negative Regulation Of Proteolysis Establishment Of Protein Localization To Organelle Negative Regulation Of Protein Processing MRNA 3'-end Processing Associative Learning Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Response To Hormone Regulation Of Peptidase Activity Negative Regulation Of Protein Homotetramerization Synaptic Growth At Neuromuscular Junction Serotonin Uptake Lactate Biosynthetic Process From Pyruvate Apoptotic Process Negative Regulation Of Cell Death Protein Targeting Feeding Behavior Programmed Cell Death Forebrain Development Regulation Of Signal Transduction RNA 3'-end Processing Reproduction Cell Death	Positive Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression RNA Metabolic Process Transcription, DNA-templated Organelle Organization Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Response To Growth Factor Cellular Response To Organic Substance Macromolecule Biosynthetic Process Viral Process Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Component Organization Regulation Of Signal Transduction Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Response To Organic Substance Cellular Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Signaling Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Developmental Process Transcription From RNA Polymerase II Promoter Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Cell Communication Regulation Of Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process
Tagcloud ?		33k butylhydroperoxide choline coa disturbed enoyl galactosidase hayflick hmsc hmscs hydratase hyperoxia inducer metabolites mlc2 myosin p30 peroxisomal premature prosomal psma1 replicative senescence shares shortening sips spots sublethal tert	1s 2a 3s 4c 4r 9r aryl carbomethoxy carboxylic dat esters ethylene flattened fluorophenyl isomers methylenedioxy nortropane paroxetine phenoxy piperidine possesses pseudoequatorial reuptake serotonin ssri stereochemistry substituent substituents win
Tagcloud (Difference) ?		33k butylhydroperoxide choline coa disturbed enoyl galactosidase hayflick hmsc hmscs hydratase hyperoxia inducer metabolites mlc2 myosin p30 peroxisomal premature prosomal psma1 replicative senescence shares shortening sips spots sublethal tert	1s 2a 3s 4c 4r 9r aryl carbomethoxy carboxylic dat esters ethylene flattened fluorophenyl isomers methylenedioxy nortropane paroxetine phenoxy piperidine possesses pseudoequatorial reuptake serotonin ssri stereochemistry substituent substituents win
Tagcloud (Intersection) ?