TSPO and ICAM3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		TSPO	ICAM3
Name		translocator protein	intercellular adhesion molecule 3
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Extracellular Exosome	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Androgen Binding Protein Binding Benzodiazepine Receptor Activity Cholesterol Binding Transmembrane Transporter Binding Cholesterol Transfer Activity	Signaling Receptor Binding Integrin Binding Protein Binding
	Biological Process	Protein Targeting To Mitochondrion Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Heme Biosynthetic Process Monoatomic Ion Transport Monoatomic Anion Transport Chloride Transport Lipid Transport Steroid Metabolic Process Glial Cell Migration Response To Xenobiotic Stimulus Response To Manganese Ion Response To Vitamin B1 Peripheral Nervous System Axon Regeneration Sterol Transport Adrenal Gland Development Negative Regulation Of Protein Ubiquitination Regulation Of Cholesterol Transport Response To Progesterone Negative Regulation Of Tumor Necrosis Factor Production Response To Testosterone Regulation Of Cell Population Proliferation Cholesterol Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Response To Pain Behavioral Response To Pain Response To Axon Injury Regulation Of Steroid Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Calcium Ion Transport Contact Inhibition Positive Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Zinc Ion Cellular Hypotonic Response Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Mitophagy Negative Regulation Of ATP Metabolic Process Response To Acetylcholine Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Corticosterone Secretion	Phagocytosis Cell Adhesion Cell-cell Adhesion
Pathways		Pregnenolone biosynthesis	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling
Drugs		Chlormezanone Zopiclone	None
GWAS		Metabolite levels ( 23823483 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) White blood cell count ( 32888494 )	Crohn's disease ( 21102463 28067908 ) Inflammatory bowel disease ( 28067908 ) Rheumatoid arthritis ( 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 )
Interacting Genes		17 interacting genes: AMIGO1 CLEC10A CREB3L1 DBI FAM209A FCER1G ICAM3 KCNF1 LEUTX LHFPL5 LYPD5 MEOX2 NCR3LG1 PVR TMEM14B TMEM9 TSPOAP1	20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16
Entrez ID		706	3385
HPRD ID		15913	00889
Ensembl ID		ENSG00000100300	ENSG00000076662
Uniprot IDs		O76068 P30536	A0A9L9PXS1 P32942
PDB IDs		Not available	1T0P
GO Terms Enriched among Interactors		Benzodiazepine Receptor Binding	Leukocyte Cell-cell Adhesion Cell-cell Adhesion ICAM-3 Receptor Activity Cell Surface Cell Adhesion External Side Of Plasma Membrane Integrin AlphaL-beta2 Complex Peptide Antigen Transport Integrin Complex Membrane Cell Adhesion Molecule Binding Regulation Of Immune System Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Membrane To Membrane Docking Cell Recognition Paracellular Transport Intracellular Transport Of Virus Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Host Cell Positive Regulation Of Protein Localization To Early Endosome Cell-cell Recognition Virion Binding Regulation Of Nitric Oxide Biosynthetic Process Virion Attachment To Host Cell Regulation Of Transport Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein Localization To Endosome Adhesion Of Symbiont To Host Cell Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Immune System Process Uropod Plasma Membrane Regulation Of Cell Population Proliferation Response To Manganese Ion Neuron Remodeling Adhesion Of Symbiont To Host Positive Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Leukocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Transport Specific Granule Membrane Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Cellular Extravasation Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Cell Activation Import Into Cell Vesicle-mediated Transport