ICAM3 and ZBTB16

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		ICAM3	ZBTB16
Gene Name		intercellular adhesion molecule 3	zinc finger and BTB domain containing 16
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome	Nucleus Nucleolus Cytosol Plasma Membrane Nuclear Body PML Body Nuclear Speck Transcriptional Repressor Complex
	Molecular Function	Receptor Binding Integrin Binding Protein Binding	RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Double-stranded DNA Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Cell Adhesion Single Organismal Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mesonephros Development Transcription, DNA-templated Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Cartilage Development
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Crohn's disease ( 21102463)	Conduct disorder (interaction) ( 18846501)
Protein-Protein Interactions		10 interactors: APP CD209 CLEC4M EZR ITGAD ITGAL ITGB2 MSN PRKCQ ZBTB16	111 interactors: ACP5 ADAMTS4 AGTR1 AGTR2 ANAPC5 ANXA7 AR ATP6AP2 ATP7B BCL6 BMI1 CASP3 CCDC109B CCDC130 CCDC85B CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COQ6 DLST DNAAF5 DNM2 DPM1 EEF1A1 EIF2S2 ENOX1 EP300 EPN1 ESR1 FAM101B FCHO1 FHL2 FSHR GATA1 GATA2 GCSH GNE GOLGA2 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX ICAM3 IL6 KIAA1549 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LSM2 LYAR MAGEA11 MAP3K3 NCOR1 NCOR2 NR3C1 PAFAH1B3 PARP1 PGAM5 PLSCR1 PMAIP1 PML PNRC2 PSMD11 PSMD2 QTRT1 RAB27A RARA RB1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TOLLIP TRAF2 TRIM27 TRIM54 TXNIP UBE2I VDR VTA1 WDR33 ZBTB32 ZNF24 ZNF281
Entrez ID		3385	7704
HPRD ID		00889	11762
Ensembl ID		ENSG00000076662	ENSG00000109906
Uniprot IDs		P32942	Q05516
PDB IDs		1T0P	1BUO 1CS3
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Single Organismal Cell-cell Adhesion Cell Adhesion Immune System Process Activated T Cell Proliferation Immune Response Peptide Antigen Transport Membrane To Membrane Docking T Cell Proliferation Virion Attachment To Host Cell Locomotion Cell Activation Regulation Of T Cell Activation Regulation Of Immune System Process Defense Response Adhesion Of Symbiont To Host Innate Immune Response Movement Of Cell Or Subcellular Component Cellular Localization Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Lymphocyte Proliferation Extracellular Structure Organization Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Regulation Of Lymphocyte Activation Leukocyte Proliferation Cell Recognition Blood Coagulation Hemostasis Regulation Of T Cell Proliferation Regulation Of Cell Activation Heterotypic Cell-cell Adhesion Modulation By Virus Of Host Morphology Or Physiology Viral Genome Replication Intracellular Transport Of Virus Establishment Of Endothelial Barrier Regulation Of Body Fluid Levels Chemotaxis Positive Regulation Of T Cell Activation Wound Healing Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Leukocyte Migration Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Endocytosis Positive Regulation Of Cell-cell Adhesion Response To Wounding Endothelial Cell Development T Cell Aggregation	Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Positive Regulation Of Metabolic Process Response To Organic Substance Developmental Process Transcription, DNA-templated Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Metabolic Process System Development Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Histone H4 Deacetylation Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Histone Deacetylation Positive Regulation Of Cellular Protein Metabolic Process Protein Deacetylation Gene Expression RNA Metabolic Process Immune System Process Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Histone H3 Deacetylation Macromolecule Biosynthetic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Signal Transduction Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Chromatin Organization Biosynthetic Process Histone H3-K9 Modification Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Cellular Metabolic Process
Tagcloud ?		br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf tnfrsf18 vegfa vegfc	approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes
Tagcloud (Difference) ?		br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf tnfrsf18 vegfa vegfc	approaches authors craniofacial create decisive dental differentiation discusses engineering excellent functions knowledge medicine necessary oral osteogenic paper processes profound putative regulate reports selected sp1 stem summarizes tp53 transcription transcriptomes
Tagcloud (Intersection) ?