ICAM3 and ITGB2

Number of citations of the paper that reports this interaction (PMID 11353828)
64

Data Source:
HPRD (in vivo, in vitro)

		ICAM3	ITGB2
Gene Name		intercellular adhesion molecule 3	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Integrin Complex Cell Surface Membrane Vesicle Integrin AlphaL-beta2 Complex Receptor Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Integrin Binding Protein Binding	Glycoprotein Binding Protein Binding Protein Kinase Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Cell Adhesion Single Organismal Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Apoptotic Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Cell-cell Signaling Aging Blood Coagulation Regulation Of Cell Shape Natural Killer Cell Activation Extracellular Matrix Organization Neutrophil Chemotaxis Heterotypic Cell-cell Adhesion Toll-like Receptor 4 Signaling Pathway Endodermal Cell Differentiation Receptor Clustering Endothelial Cell Migration Innate Immune Response Cellular Extravasation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Activated T Cell Proliferation Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System Innate Immune System
Drugs			Simvastatin
Diseases
GWAS		Crohn's disease ( 21102463)
Protein-Protein Interactions		10 interactors: APP CD209 CLEC4M EZR ITGAD ITGAL ITGB2 MSN PRKCQ ZBTB16	41 interactors: CD14 CD226 CD82 COPS3 COPS5 CYTH1 CYTH2 DAB1 DOK1 ESM1 FCER2 FHL2 FUT4 GNB2L1 HP ICAM1 ICAM2 ICAM3 ICAM4 ICAM5 ILK ITGAD ITGAM ITGAX KNG1 NOTCH2NL NUMB PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRTN3 PTK2 PTK2B RANBP9 RDX SYK TLN1 VNN2
Entrez ID		3385	3689
HPRD ID		00889	02506
Ensembl ID		ENSG00000076662	ENSG00000160255
Uniprot IDs		P32942	A8MYE6 P05107
PDB IDs		1T0P	1JX3 1L3Y 1YUK 2JF1 2P26 2P28 2V7D 3K6S 3K71 3K72
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Single Organismal Cell-cell Adhesion Cell Adhesion Immune System Process Activated T Cell Proliferation Immune Response Peptide Antigen Transport Membrane To Membrane Docking T Cell Proliferation Virion Attachment To Host Cell Locomotion Cell Activation Regulation Of T Cell Activation Regulation Of Immune System Process Defense Response Adhesion Of Symbiont To Host Innate Immune Response Movement Of Cell Or Subcellular Component Cellular Localization Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Lymphocyte Proliferation Extracellular Structure Organization Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Regulation Of Lymphocyte Activation Leukocyte Proliferation Cell Recognition Blood Coagulation Hemostasis Regulation Of T Cell Proliferation Regulation Of Cell Activation Heterotypic Cell-cell Adhesion Modulation By Virus Of Host Morphology Or Physiology Viral Genome Replication Intracellular Transport Of Virus Establishment Of Endothelial Barrier Regulation Of Body Fluid Levels Chemotaxis Positive Regulation Of T Cell Activation Wound Healing Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Leukocyte Migration Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Endocytosis Positive Regulation Of Cell-cell Adhesion Response To Wounding Endothelial Cell Development T Cell Aggregation	Blood Coagulation Hemostasis Platelet Activation Cell Activation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cell Adhesion Regulation Of Immune System Process Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Single Organismal Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Integrin-mediated Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Signal Transduction Defense Response Signal Transduction Regulation Of Cellular Component Organization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Glial Cell Apoptotic Process Movement Of Cell Or Subcellular Component Locomotion Regulation Of Signaling Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To External Stimulus Cell Surface Receptor Signaling Pathway Signaling Positive Regulation Of Immune Response Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Immune System Process Positive Regulation Of Phosphorylation Leukocyte Activation Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Activation Of Phospholipase C Activity
Tagcloud ?		br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf tnfrsf18 vegfa vegfc	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Difference) ?		br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf tnfrsf18 vegfa vegfc	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgal loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Intersection) ?