TSPO and DBI

Number of citations: 0 (PubMedID 7626442)
Data Source: HPRD (in vitro, in vivo)

		TSPO	DBI
Name		translocator protein	diazepam binding inhibitor, acyl-CoA binding protein
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Golgi Apparatus Protein-lipid Complex Extracellular Exosome Perinuclear Endoplasmic Reticulum
	Molecular Function	Androgen Binding Protein Binding Benzodiazepine Receptor Activity Cholesterol Binding Transmembrane Transporter Binding Cholesterol Transfer Activity	Fatty-acyl-CoA Binding Protein Binding Lipid Binding Benzodiazepine Receptor Binding Long-chain Fatty Acyl-CoA Binding Identical Protein Binding
	Biological Process	Protein Targeting To Mitochondrion Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Heme Biosynthetic Process Monoatomic Ion Transport Monoatomic Anion Transport Chloride Transport Lipid Transport Steroid Metabolic Process Glial Cell Migration Response To Xenobiotic Stimulus Response To Manganese Ion Response To Vitamin B1 Peripheral Nervous System Axon Regeneration Sterol Transport Adrenal Gland Development Negative Regulation Of Protein Ubiquitination Regulation Of Cholesterol Transport Response To Progesterone Negative Regulation Of Tumor Necrosis Factor Production Response To Testosterone Regulation Of Cell Population Proliferation Cholesterol Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Response To Pain Behavioral Response To Pain Response To Axon Injury Regulation Of Steroid Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Calcium Ion Transport Contact Inhibition Positive Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Zinc Ion Cellular Hypotonic Response Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Mitophagy Negative Regulation Of ATP Metabolic Process Response To Acetylcholine Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Corticosterone Secretion	Fatty Acid Metabolic Process Phosphatidylcholine Acyl-chain Remodeling Negative Regulation Of Protein Lipidation Positive Regulation Of Phospholipid Transport
Pathways		Pregnenolone biosynthesis	Mitochondrial Fatty Acid Beta-Oxidation
Drugs		Chlormezanone Zopiclone	Coenzyme A Hexadecanal
GWAS		Metabolite levels ( 23823483 ) Monocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) White blood cell count ( 32888494 )	Obesity-related traits ( 23251661 )
Novel Interactors		1 novel interactors: TSPAN15	None recorded
Interacting Genes		17 interacting genes: AMIGO1 CLEC10A CREB3L1 DBI FAM209A FCER1G ICAM3 KCNF1 LEUTX LHFPL5 LYPD5 MEOX2 NCR3LG1 PVR TMEM14B TMEM9 TSPOAP1	14 interacting genes: CYSLTR2 DDIT4L DUSP23 GSK3B LAMTOR5 MAP1LC3B NIPSNAP1 NSFL1C PFDN2 PPCDC RAD23A RAD23B TSPO UBXN2A
Entrez ID		706	1622
HPRD ID		15913	08832
Ensembl ID		ENSG00000100300	ENSG00000155368
Uniprot IDs		O76068 P30536	A0A024RAF2 B8ZWD1 B8ZWD8 P07108
PDB IDs		Not available	2CB8 2FJ9
GO Terms Enriched among Interactors		Benzodiazepine Receptor Binding	Ubiquitin Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Localization To Centrosome Proteasomal Protein Catabolic Process Autophagosome Assembly Autophagosome Organization Protein Catabolic Process Proteasome Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Organelle Assembly Nuclear Membrane Reassembly Regulation Of Proteolysis Cytosol Regulation Of Ubiquitin-dependent Protein Catabolic Process Catabolic Process Vacuole Organization Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Negative Regulation Of Corticosterone Secretion Regulation Of Protein Metabolic Process Regulation Of Microtubule Anchoring At Centrosome Nuclear Membrane Organization Cysteinyl Leukotriene Receptor Activity Phosphopantothenoylcysteine Decarboxylase Activity Phosphopantothenoylcysteine Decarboxylase Complex Nucleotide-excision Repair Regulation Of Post-translational Protein Modification Macromolecule Catabolic Process Mitophagy Membrane Assembly Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Proteasome Complex Damaged DNA Binding Superior Temporal Gyrus Development Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Autophagy Of Mitochondrion VCP-NSFL1C Complex Negative Regulation Of Protein Localization To Centrosome Proteolysis Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process