TSPO and LEUTX

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSPO	LEUTX
Description		translocator protein	leucine twenty homeobox
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Extracellular Exosome	Chromatin Nucleus Nucleoplasm
	Molecular Function	Androgen Binding Protein Binding Benzodiazepine Receptor Activity Cholesterol Binding Transmembrane Transporter Binding Cholesterol Transfer Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding
	Biological Process	Protein Targeting To Mitochondrion Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Heme Biosynthetic Process Monoatomic Ion Transport Monoatomic Anion Transport Chloride Transport Lipid Transport Steroid Metabolic Process Glial Cell Migration Response To Xenobiotic Stimulus Response To Manganese Ion Response To Vitamin B1 Peripheral Nervous System Axon Regeneration Sterol Transport Adrenal Gland Development Negative Regulation Of Protein Ubiquitination Regulation Of Cholesterol Transport Response To Progesterone Negative Regulation Of Tumor Necrosis Factor Production Response To Testosterone Regulation Of Cell Population Proliferation Cholesterol Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Response To Pain Behavioral Response To Pain Response To Axon Injury Regulation Of Steroid Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Calcium Ion Transport Contact Inhibition Positive Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Zinc Ion Cellular Hypotonic Response Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Mitophagy Negative Regulation Of ATP Metabolic Process Response To Acetylcholine Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Corticosterone Secretion	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Pregnenolone biosynthesis	Zygotic genome activation (ZGA)
Drugs		Chlormezanone Zopiclone
Diseases
GWAS		Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) White blood cell count ( 32888494)	Macular thickness ( 30535121)
Interacting Genes		17 interacting genes: AMIGO1 CLEC10A CREB3L1 DBI FAM209A FCER1G ICAM3 KCNF1 LEUTX LHFPL5 LYPD5 MEOX2 NCR3LG1 PVR TMEM14B TMEM9 TSPOAP1	46 interacting genes: AGPAT4 AIG1 AQP2 AQP3 ASGR1 C1GALT1 C1QL4 C3orf52 CDS2 CMTM3 CMTM5 CNIH1 CNIH3 CXCL9 EMP3 ENTPD3 FAM24B FZD7 GOSR2 KIR2DL3 LAT MRPL57 MS4A1 NAPB NDRG4 OLFM4 PLP1 PNLIPRP1 PRB1 SLC13A3 SLC30A8 SLC41A2 STATH TF TMEM128 TMEM147 TMEM187 TMEM254 TMEM60 TMEM97 TSPO TTPA UNC93B1 VAMP4 ZFPL1 ZNF646
Entrez ID		706	342900
HPRD ID		15913
Ensembl ID		ENSG00000100300	ENSG00000213921
Uniprot IDs		O76068 P30536	A8MZ59
PDB IDs
Enriched GO Terms of Interacting Partners?		Benzodiazepine Receptor Binding	Membrane
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