ICAM3 and ITGAL

Number of citations of the paper that reports this interaction (PMID 11353828)
64

Data Source:
HPRD (in vitro, in vivo)

		ICAM3	ITGAL
Gene Name		intercellular adhesion molecule 3	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome	Immunological Synapse Plasma Membrane Cell-cell Junction Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Integrin AlphaL-beta2 Complex Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Integrin Binding Protein Binding	Protein Binding ICAM-3 Receptor Activity Protein Complex Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Cell Adhesion Single Organismal Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Movement Of Cell Or Subcellular Component Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Blood Coagulation Extracellular Matrix Organization Positive Regulation Of T Cell Proliferation Receptor Clustering Regulation Of Immune Response Activated T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling Leukocyte Migration
Pathways		Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System
Drugs			Efalizumab Antithymocyte globulin Lovastatin 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine LFA703 (S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline
Diseases
GWAS		Crohn's disease ( 21102463)	Ulcerative colitis ( 23128233)
Protein-Protein Interactions		10 interactors: APP CD209 CLEC4M EZR ITGAD ITGAL ITGB2 MSN PRKCQ ZBTB16	7 interactors: F11R ICAM1 ICAM3 ICAM5 PTPRC RANBP9 SHARPIN
Entrez ID		3385	3683
HPRD ID		00889	01079
Ensembl ID		ENSG00000076662	ENSG00000005844
Uniprot IDs		P32942	B2RAL6 P20701
PDB IDs		1T0P	1CQP 1DGQ 1IJ4 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Single Organismal Cell-cell Adhesion Cell Adhesion Immune System Process Activated T Cell Proliferation Immune Response Peptide Antigen Transport Membrane To Membrane Docking T Cell Proliferation Virion Attachment To Host Cell Locomotion Cell Activation Regulation Of T Cell Activation Regulation Of Immune System Process Defense Response Adhesion Of Symbiont To Host Innate Immune Response Movement Of Cell Or Subcellular Component Cellular Localization Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Lymphocyte Proliferation Extracellular Structure Organization Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Regulation Of Lymphocyte Activation Leukocyte Proliferation Cell Recognition Blood Coagulation Hemostasis Regulation Of T Cell Proliferation Regulation Of Cell Activation Heterotypic Cell-cell Adhesion Modulation By Virus Of Host Morphology Or Physiology Viral Genome Replication Intracellular Transport Of Virus Establishment Of Endothelial Barrier Regulation Of Body Fluid Levels Chemotaxis Positive Regulation Of T Cell Activation Wound Healing Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Leukocyte Migration Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Endocytosis Positive Regulation Of Cell-cell Adhesion Response To Wounding Endothelial Cell Development T Cell Aggregation	Cell Adhesion Single Organismal Cell-cell Adhesion Establishment Of Endothelial Barrier Endothelial Cell Development Extracellular Matrix Organization Extracellular Structure Organization Endothelial Cell Differentiation Response To Radiation Locomotion Response To Sulfur Dioxide Endothelium Development Regulation Of Cytokine-mediated Signaling Pathway Epithelial Cell Differentiation Regulation Of Leukocyte Mediated Cytotoxicity Movement Of Cell Or Subcellular Component T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration Response To Ionizing Radiation Tissue Development Regulation Of CD40 Signaling Pathway Protein Linear Polyubiquitination Regulation Of Intracellular Signal Transduction Cell Development Cell Differentiation Positive Regulation Of Intracellular Signal Transduction Cell Migration T Cell Antigen Processing And Presentation Receptor-mediated Virion Attachment To Host Cell Membrane To Membrane Docking Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Immune Response Epithelial Cell Development Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cellular Extravasation Negative Regulation Of T Cell Mediated Cytotoxicity Cell Motility Leukocyte Migration Establishment Of Sertoli Cell Barrier Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Isotype Switching To IgG Isotypes Bone Marrow Development Virion Attachment To Host Cell Response To Virus Positive Regulation Of Gamma-delta T Cell Differentiation Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Isotype Switching To IgG Isotypes Adhesion Of Symbiont To Host
Tagcloud ?		br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf tnfrsf18 vegfa vegfc	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgb2 loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Difference) ?		br ccl20 ccl3 ccl4 csf2 csf3 cxcl1 cxcl12 discordances extremities figf grew igfbp1 iib il1alpha il1beta il6 il8 lymphatic matrigel mmp1 mmp13 mmp9 mts6 plaur plgf tnfrsf18 vegfa vegfc	a2 caucasians cd8a concepts controversial encode highlighted hla icam il1b il2 itgb2 loadings meta mining modifier nonrandomly pooled ranked retrieved sell selp shared silico spite synapses text top truly
Tagcloud (Intersection) ?