ICAM3 and ITGAD

Number of citations of the paper that reports this interaction (PubMedID 8777714)
0

Data Source:
HPRD (in vitro)

		ICAM3	ITGAD
Description		intercellular adhesion molecule 3	integrin subunit alpha D
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Plasma Membrane Integrin Complex Cell Surface Membrane
	Molecular Function	Signaling Receptor Binding Integrin Binding Protein Binding	Signaling Receptor Activity Metal Ion Binding
	Biological Process	Phagocytosis Cell Adhesion Cell-cell Adhesion	Immune Response Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heterotypic Cell-cell Adhesion Cell-cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling	Integrin cell surface interactions
Drugs
Diseases
GWAS		Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin ( 27863252) Platelet count ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16	4 interacting genes: ICAM3 ITGB2 SHARPIN VCAM1
Entrez ID		3385	3681
HPRD ID		00889	11785
Ensembl ID		ENSG00000076662	ENSG00000156886
Uniprot IDs		A0A9L9PXS1 P32942	Q13349 Q59H14
PDB IDs		1T0P
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Cell-cell Adhesion ICAM-3 Receptor Activity Cell Surface Cell Adhesion External Side Of Plasma Membrane Integrin AlphaL-beta2 Complex Peptide Antigen Transport Integrin Complex Membrane Cell Adhesion Molecule Binding Regulation Of Immune System Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Membrane To Membrane Docking Cell Recognition Paracellular Transport Intracellular Transport Of Virus Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Host Cell Positive Regulation Of Protein Localization To Early Endosome Cell-cell Recognition Virion Binding Regulation Of Nitric Oxide Biosynthetic Process Virion Attachment To Host Cell Regulation Of Transport Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein Localization To Endosome Adhesion Of Symbiont To Host Cell Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Immune System Process Uropod Plasma Membrane Regulation Of Cell Population Proliferation Response To Manganese Ion Neuron Remodeling Adhesion Of Symbiont To Host Positive Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Leukocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Transport Specific Granule Membrane Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Cellular Extravasation Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Cell Activation Import Into Cell Vesicle-mediated Transport	Integrin Binding Cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Leukocyte Cell-cell Adhesion Cell-cell Adhesion Phagocytosis Cell-matrix Adhesion Cell Adhesion Molecule Binding Alpha9-beta1 Integrin-vascular Cell Adhesion Molecule-1 Complex Cardiac Neuron Differentiation Cell Adhesion Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Cell-substrate Adhesion Integrin AlphaL-beta2 Complex Peripheral Nervous System Neuron Differentiation ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Chemotaxis Negative Regulation Of Dopamine Metabolic Process LUBAC Complex Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Regulation Of Neutrophil Degranulation Positive Regulation Of Leukocyte Cell-cell Adhesion Primary Methylamine Oxidase Activity Cell-cell Adhesion Mediated By Integrin Apoptotic Nuclear Changes Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway Defense Response Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Chemotaxis Positive Regulation Of Cell-cell Adhesion Chronic Inflammatory Response External Side Of Plasma Membrane Locomotion Complement Component C3b Binding Cell Adhesion Mediator Activity Regulation Of Leukocyte Cell-cell Adhesion Endocytosis Regulation Of Dopamine Metabolic Process Positive Regulation Of Cell Adhesion Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Leukocyte Migration Involved In Inflammatory Response Cellular Extravasation Innervation Leukocyte Tethering Or Rolling
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