ICAM3 and SMCO4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ICAM3	SMCO4
Description		intercellular adhesion molecule 3	single-pass membrane protein with coiled-coil domains 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Membrane
	Molecular Function	Signaling Receptor Binding Integrin Binding Protein Binding	Protein Binding
	Biological Process	Phagocytosis Cell Adhesion Cell-cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling
Drugs
Diseases
GWAS		Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Adult body size ( 32376654) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Liver enzyme levels (alanine transaminase) ( 33972514)
Interacting Genes		20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16	62 interacting genes: AQP6 ARL13B BNIP3L CD79A CLEC10A CLTRN CPLX4 CREB3L1 CXCR2 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FFAR2 GJA8 GKN1 GPA33 GPR152 GPR42 HHLA2 ICAM3 IL10RA KASH5 KCNK5 KIR3DL1 KRT40 KRTAP10-3 KRTAP10-7 LEPROTL1 LMNA LRRC25 M6PR MGST3 MS4A3 MUC1 PEX12 PLD3 PTGES RETREG3 SCN3B SLC10A6 SLC16A2 SLC18A1 SLC35H1 SLC41A3 SLC7A1 SLC7A14 SMIM3 SPINT1 STOM SUSD3 SYNE4 SYNPR TEX29 TFEC TMEM139 TMEM80 TMX2 VSIR WBP1
Entrez ID		3385	56935
HPRD ID		00889	17008
Ensembl ID		ENSG00000076662	ENSG00000166002
Uniprot IDs		A0A9L9PXS1 P32942	Q9NRQ5
PDB IDs		1T0P
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Cell-cell Adhesion ICAM-3 Receptor Activity Cell Surface Cell Adhesion External Side Of Plasma Membrane Integrin AlphaL-beta2 Complex Peptide Antigen Transport Integrin Complex Membrane Cell Adhesion Molecule Binding Regulation Of Immune System Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Membrane To Membrane Docking Cell Recognition Paracellular Transport Intracellular Transport Of Virus Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Host Cell Positive Regulation Of Protein Localization To Early Endosome Cell-cell Recognition Virion Binding Regulation Of Nitric Oxide Biosynthetic Process Virion Attachment To Host Cell Regulation Of Transport Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein Localization To Endosome Adhesion Of Symbiont To Host Cell Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Immune System Process Uropod Plasma Membrane Regulation Of Cell Population Proliferation Response To Manganese Ion Neuron Remodeling Adhesion Of Symbiont To Host Positive Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Leukocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Transport Specific Granule Membrane Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Cellular Extravasation Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Cell Activation Import Into Cell Vesicle-mediated Transport	Membrane Protein Binding
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