TSPO and TSPAN15

		TSPO	TSPAN15
Description		translocator protein	tetraspanin 15
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Mitochondrial Membrane Extracellular Exosome	Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Late Endosome Membrane Tetraspanin-enriched Microdomain
	Molecular Function	Androgen Binding Protein Binding Benzodiazepine Receptor Activity Cholesterol Binding Transmembrane Transporter Binding Cholesterol Transfer Activity	Protein Binding Enzyme Binding
	Biological Process	Protein Targeting To Mitochondrion Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Heme Biosynthetic Process Monoatomic Ion Transport Monoatomic Anion Transport Chloride Transport Lipid Transport Steroid Metabolic Process Glial Cell Migration Response To Xenobiotic Stimulus Response To Manganese Ion Response To Vitamin B1 Peripheral Nervous System Axon Regeneration Sterol Transport Adrenal Gland Development Negative Regulation Of Protein Ubiquitination Regulation Of Cholesterol Transport Response To Progesterone Negative Regulation Of Tumor Necrosis Factor Production Response To Testosterone Regulation Of Cell Population Proliferation Cholesterol Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Response To Pain Behavioral Response To Pain Response To Axon Injury Regulation Of Steroid Biosynthetic Process Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of Calcium Ion Transport Contact Inhibition Positive Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Proliferation Positive Regulation Of Programmed Necrotic Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Zinc Ion Cellular Hypotonic Response Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Negative Regulation Of Mitophagy Negative Regulation Of ATP Metabolic Process Response To Acetylcholine Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Corticosterone Secretion	Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway Regulation Of Membrane Protein Ectodomain Proteolysis Protein Maturation Protein Localization To Plasma Membrane
Pathways		Pregnenolone biosynthesis	Amyloid fiber formation
Drugs		Chlormezanone Zopiclone
Diseases
GWAS		Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) White blood cell count ( 32888494)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Response to taxane treatment (paclitaxel) ( 23006423) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombosis ( 26908601) Type 2 diabetes ( 32499647) Venous thromboembolism ( 25772935 28373160 31420334 31676865)
Interacting Genes		17 interacting genes: AMIGO1 CLEC10A CREB3L1 DBI FAM209A FCER1G ICAM3 KCNF1 LEUTX LHFPL5 LYPD5 MEOX2 NCR3LG1 PVR TMEM14B TMEM9 TSPOAP1	5 interacting genes: BTRC GYPC RGS2 STRIT1 SYNE4
Entrez ID		706	23555
HPRD ID		15913	15511
Ensembl ID		ENSG00000100300	ENSG00000099282
Uniprot IDs		O76068 P30536	O95858
PDB IDs			7RD5 7RDB 8ESV
Enriched GO Terms of Interacting Partners?		Benzodiazepine Receptor Binding
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