ICAM3 and CD209

Number of citations of the paper that reports this interaction (PubMedID 11017109)
0

Data Source:
HPRD (in vitro, in vivo)

		ICAM3	CD209
Description		intercellular adhesion molecule 3	CD209 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Cytoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Host Cell
	Molecular Function	Signaling Receptor Binding Integrin Binding Protein Binding	Virus Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Peptide Antigen Binding Virion Binding Metal Ion Binding
	Biological Process	Phagocytosis Cell Adhesion Cell-cell Adhesion	Adaptive Immune Response Immune System Process Endocytosis Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-cell Recognition Virion Attachment To Host Cell Viral Genome Replication Antigen Processing And Presentation Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation Regulation Of T Cell Proliferation Innate Immune Response Symbiont Entry Into Host Cell Peptide Antigen Transport Intracellular Transport Of Virus B Cell Adhesion Positive Regulation Of Viral Life Cycle
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling	CD209 (DC-SIGN) signaling Butyrophilin (BTN) family interactions RSV-host interactions
Drugs
Diseases
GWAS		Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Blood protein levels ( 30072576)
Interacting Genes		20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16	10 interacting genes: CEACAM1 CLEC4M CLU CRYAA ICAM2 ICAM3 IFT20 ITGAM TCEAL8 VAC14
Entrez ID		3385	30835
HPRD ID		00889	05241
Ensembl ID		ENSG00000076662	ENSG00000090659
Uniprot IDs		A0A9L9PXS1 P32942	B2R907 B4E2A8 M0R0P0 Q9NNX6 X6RB12
PDB IDs		1T0P	1K9I 1SL4 1SL5 2B6B 2IT5 2IT6 2XR5 2XR6 6GHV 7NL6 7NL7 9EMQ 9EMR 9EMS
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Cell-cell Adhesion ICAM-3 Receptor Activity Cell Surface Cell Adhesion External Side Of Plasma Membrane Integrin AlphaL-beta2 Complex Peptide Antigen Transport Integrin Complex Membrane Cell Adhesion Molecule Binding Regulation Of Immune System Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Membrane To Membrane Docking Cell Recognition Paracellular Transport Intracellular Transport Of Virus Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Host Cell Positive Regulation Of Protein Localization To Early Endosome Cell-cell Recognition Virion Binding Regulation Of Nitric Oxide Biosynthetic Process Virion Attachment To Host Cell Regulation Of Transport Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein Localization To Endosome Adhesion Of Symbiont To Host Cell Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Immune System Process Uropod Plasma Membrane Regulation Of Cell Population Proliferation Response To Manganese Ion Neuron Remodeling Adhesion Of Symbiont To Host Positive Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Leukocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Transport Specific Granule Membrane Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Cellular Extravasation Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Cell Activation Import Into Cell Vesicle-mediated Transport	Cell-cell Adhesion Endocytosis Cell Adhesion Amyloid-beta Clearance Integrin Binding Receptor-mediated Endocytosis Microglial Cell Activation Regulation Of Vesicle-mediated Transport Leukocyte Activation Involved In Inflammatory Response Import Into Cell Signaling Receptor Activity Macrophage Activation Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction PAS Complex Tertiary Granule Membrane Microvillus Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Insulin Receptor Internalization Negative Regulation Of Cytotoxic T Cell Degranulation Negative Regulation Of Hepatocyte Proliferation Regulation Of Transport Regulation Of Leukocyte Mediated Cytotoxicity Specific Granule Membrane Integrin-mediated Signaling Pathway Cell Periphery Amyloid-beta Binding Negative Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Neurofibrillary Tangle Assembly Central Nervous System Myelin Maintenance Immune Complex Clearance Integrin AlphaM-beta2 Complex Positive Regulation Of Neutrophil Degranulation Response To Curcumin Vertebrate Eye-specific Patterning ICAM-3 Receptor Activity Peptide Antigen Transport Kinociliary Basal Body Opsin Transport Intraciliary Transport Particle Unfolded Protein Binding Insulin Catabolic Process Regulation Of Regulated Secretory Pathway Regulation Of Receptor-mediated Endocytosis Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Microglial Cell Mediated Cytotoxicity Complement-mediated Synapse Pruning Opsin Binding
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