ICAM3 and EDDM3B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ICAM3	EDDM3B
Description		intercellular adhesion molecule 3	epididymal protein 3B
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Extracellular Exosome	Extracellular Region
	Molecular Function	Signaling Receptor Binding Integrin Binding Protein Binding	Protein Binding
	Biological Process	Phagocytosis Cell Adhesion Cell-cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling
Drugs
Diseases
GWAS		Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16	22 interacting genes: AMIGO1 CD74 CD79A CLDN7 COX8A FFAR2 FNDC9 GPR152 GPX8 ICAM3 JPH1 KCNJ6 KIR3DL3 LMNA LRRC25 LRRC59 MUC1 PVR SUSD3 SYNE4 TMEM106C TMPRSS2
Entrez ID		3385	64184
HPRD ID		00889	13290
Ensembl ID		ENSG00000076662	ENSG00000181552
Uniprot IDs		A0A9L9PXS1 P32942	P56851 W0UV31
PDB IDs		1T0P
Enriched GO Terms of Interacting Partners?		Leukocyte Cell-cell Adhesion Cell-cell Adhesion ICAM-3 Receptor Activity Cell Surface Cell Adhesion External Side Of Plasma Membrane Integrin AlphaL-beta2 Complex Peptide Antigen Transport Integrin Complex Membrane Cell Adhesion Molecule Binding Regulation Of Immune System Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Membrane To Membrane Docking Cell Recognition Paracellular Transport Intracellular Transport Of Virus Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport Host Cell Positive Regulation Of Protein Localization To Early Endosome Cell-cell Recognition Virion Binding Regulation Of Nitric Oxide Biosynthetic Process Virion Attachment To Host Cell Regulation Of Transport Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Protein Localization To Endosome Adhesion Of Symbiont To Host Cell Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Immune System Process Uropod Plasma Membrane Regulation Of Cell Population Proliferation Response To Manganese Ion Neuron Remodeling Adhesion Of Symbiont To Host Positive Regulation Of Multicellular Organismal Process Regulation Of Vesicle-mediated Transport Leukocyte Activation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Transport Specific Granule Membrane Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Cellular Extravasation Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Cell Activation Import Into Cell Vesicle-mediated Transport	Membrane Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Plasma Membrane Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Viral Entry Into Host Cell Regulation Of Viral Entry Into Host Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Viral Life Cycle
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