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THBD and PF4
Number of citations of the paper that reports this interaction (PubMedID
9395524
)
0
Data Source:
HPRD
(in vitro)
THBD
PF4
Description
thrombomodulin
platelet factor 4
Image
GO Annotations
Cellular Component
Extracellular Space
Vacuolar Membrane
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Apicolateral Plasma Membrane
Serine-type Endopeptidase Complex
Extracellular Region
Extracellular Space
Cytoplasm
Extracellular Matrix
Platelet Alpha Granule Lumen
Molecular Function
Transmembrane Signaling Receptor Activity
Calcium Ion Binding
Protein Binding
Signaling Receptor Activity
Cytokine Activity
Protein Binding
Chemokine Activity
Heparin Binding
CXCR Chemokine Receptor Binding
Receptor Ligand Activity
CXCR3 Chemokine Receptor Binding
Biological Process
Proteolysis
Female Pregnancy
Blood Coagulation
Hemostasis
Response To X-ray
Negative Regulation Of Platelet Activation
Negative Regulation Of Blood Coagulation
Zymogen Activation
Response To Lipopolysaccharide
Negative Regulation Of Coagulation
Response To CAMP
Negative Regulation Of Fibrinolysis
Blood Coagulation, Common Pathway
Monocyte Chemotaxis
Chemotaxis
Defense Response
Inflammatory Response
Immune Response
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Angiogenesis
Cytokine-mediated Signaling Pathway
Platelet Activation
Negative Regulation Of Blood Coagulation
Neutrophil Chemotaxis
Leukocyte Chemotaxis
Killing Of Cells Of Another Organism
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Cell Population Proliferation
Defense Response To Protozoan
Negative Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of Macrophage Differentiation
Negative Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Killing By Host Of Symbiont Cells
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Cellular Response To Lipopolysaccharide
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Common Pathway of Fibrin Clot Formation
Cell surface interactions at the vascular wall
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Cell surface interactions at the vascular wall
Chemokine receptors bind chemokines
G alpha (i) signalling events
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Drotrecogin alfa
Ibuprofen
Dexibuprofen
Drotrecogin alfa
Heparin
Diseases
Inherited thrombophilia
GWAS
Blood protein levels in cardiovascular risk (
28369058
)
Lung function (FVC) in asthma (
32989782
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Venous thromboembolism (
26888256
)
Inflammatory bowel disease (
23128233
)
Metabolite levels (
22916037
)
Serum metabolite levels (
31636271
)
Serum metabolite levels (CMS) (
31636271
)
Interacting Genes
33 interacting genes:
AIG1
APOC2
APOC4
AQP6
CD79A
CIDEB
CYBC1
EBP
ERGIC3
F2
FAM209A
FCER1G
GPR152
GPX8
KIR2DL3
LMNA
MMGT1
MTIF3
MUC1
PDZK1IP1
PF4
PHF24
PROC
PSENEN
RHBDD2
SERPINA5
SLC10A6
SLC19A3
SLC35H1
TMEM14B
TMEM35A
TMEM86B
TMX2
29 interacting genes:
CCL11
CCL13
CCL2
CCL20
CCL21
CCL25
CCL26
CCL28
CCL5
CXCL10
CXCL11
CXCL12
CXCL14
CXCL17
CXCL2
CXCL6
CXCL8
CXCL9
CXCR3
FGF2
LDLR
PROC
SDC2
SNCA
SRGN
THBD
VCAN
XCL1
XCL2
Entrez ID
7056
5196
HPRD ID
01764
01426
Ensembl ID
ENSG00000178726
ENSG00000163737
Uniprot IDs
P07204
P02776
PDB IDs
1ADX
1DQB
1DX5
1EGT
1FGD
1FGE
1HLT
1TMR
1ZAQ
2ADX
3GIS
5TO3
7T4R
1DN3
1F9Q
1F9R
1F9S
1PFM
1PFN
1RHP
4R9W
4R9Y
4RAU
Enriched GO Terms of Interacting Partners
?
Membrane
Endoplasmic Reticulum Membrane
Negative Regulation Of Coagulation
Negative Regulation Of Blood Coagulation
Negative Regulation Of Hemostasis
Lipid Transport
Protein Binding
Organic Hydroxy Compound Transport
Identical Protein Binding
Negative Regulation Of Wound Healing
Regulation Of Hemostasis
Regulation Of Blood Coagulation
Endoplasmic Reticulum
Positive Regulation Of Protein Localization To Cell Surface
Very-low-density Lipoprotein Particle
Chemokine Activity
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Cell Chemotaxis
Chemotaxis
Antimicrobial Humoral Response
Cytokine Activity
Locomotion
Leukocyte Chemotaxis
Chemokine-mediated Signaling Pathway
Humoral Immune Response
Leukocyte Migration
Cell Migration
Extracellular Space
Cell Motility
Granulocyte Chemotaxis
Killing Of Cells Of Another Organism
Granulocyte Migration
Myeloid Leukocyte Migration
Cell Killing
Inflammatory Response
CCR Chemokine Receptor Binding
Defense Response To Symbiont
Extracellular Region
Defense Response To Other Organism
Response To External Biotic Stimulus
Mononuclear Cell Migration
Cytokine-mediated Signaling Pathway
Immune Response
Positive Regulation Of Locomotion
Response To Other Organism
Positive Regulation Of Chemotaxis
Defense Response
Immune System Process
Regulation Of Leukocyte Migration
Eosinophil Chemotaxis
Positive Regulation Of Cell Migration
Eosinophil Migration
Chemokine Receptor Binding
Regulation Of Locomotion
Positive Regulation Of Cell Motility
G Protein-coupled Receptor Signaling Pathway
Regulation Of Cell Migration
Regulation Of Chemotaxis
CXCR Chemokine Receptor Binding
Lymphocyte Migration
Regulation Of Cell Motility
Positive Regulation Of Calcium Ion Transport
T Cell Migration
Response To Stress
Lymphocyte Chemotaxis
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Tagcloud (Difference)
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Tagcloud (Intersection)
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