THBD and FCER1G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		THBD	FCER1G
Description		thrombomodulin	Fc epsilon receptor Ig
Image
GO Annotations	Cellular Component	Extracellular Space Vacuolar Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Apicolateral Plasma Membrane Serine-type Endopeptidase Complex	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Fc-epsilon Receptor I Complex Fc-gamma Receptor III Complex Tertiary Granule Membrane Plasma Membrane Protein Complex Ficolin-1-rich Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding Signaling Receptor Activity	Transmembrane Signaling Receptor Activity Protein Binding IgE Receptor Activity IgE Binding IgG Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Proteolysis Female Pregnancy Blood Coagulation Hemostasis Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Zymogen Activation Response To Lipopolysaccharide Negative Regulation Of Coagulation Response To CAMP Negative Regulation Of Fibrinolysis Blood Coagulation, Common Pathway	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Neutrophil Activation Involved In Immune Response T Cell Differentiation Involved In Immune Response Immune System Process Fc Receptor Mediated Stimulatory Signaling Pathway Serotonin Secretion By Platelet Phagocytosis, Engulfment Signal Transduction Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Osteoclast Differentiation Neutrophil Chemotaxis Receptor Internalization Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Mast Cell Apoptotic Process Negative Regulation Of Mast Cell Apoptotic Process Fc-gamma Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Interleukin-3-mediated Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Mast Cell Degranulation Positive Regulation Of Mast Cell Degranulation Innate Immune Response Mast Cell Activation Positive Regulation Of Phagocytosis Regulation Of Immune Response Positive Regulation Of Immune Response Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall	GPVI-mediated activation cascade Cell surface interactions at the vascular wall Fc epsilon receptor (FCERI) signaling Fc epsilon receptor (FCERI) signaling Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization FCERI mediated NF-kB activation Dectin-2 family Dectin-2 family Neutrophil degranulation Platelet Adhesion to exposed collagen
Drugs		Drotrecogin alfa Ibuprofen Dexibuprofen	Benzylpenicilloyl polylysine
Diseases		Inherited thrombophilia
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Lung function (FVC) in asthma ( 32989782) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Venous thromboembolism ( 26888256)	Aggressive periodontitis ( 28449029) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 30929738 31361310 31619474 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Mean platelet volume ( 27863252 32888494) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		33 interacting genes: AIG1 APOC2 APOC4 AQP6 CD79A CIDEB CYBC1 EBP ERGIC3 F2 FAM209A FCER1G GPR152 GPX8 KIR2DL3 LMNA MMGT1 MTIF3 MUC1 PDZK1IP1 PF4 PHF24 PROC PSENEN RHBDD2 SERPINA5 SLC10A6 SLC19A3 SLC35H1 TMEM14B TMEM35A TMEM86B TMX2	83 interacting genes: ADGRE2 C2CD2L CDIPT CERS4 CLCA4 CLEC4E CNIH1 COX20 CYP4F2 DEFB127 DGAT2L6 EBP FA2H FAM209A FAXDC2 FCER1A FCGR3A FFAR2 FUNDC2 FXYD6 GIMAP5 GJA5 GP6 GPR61 IER3IP1 KCNA1 KCNN3 KIR2DL4 LEPROTL1 LMNA LNPEP LYN MFF MGLL NCR1 NCR3 NRM ORMDL2 PDZK1IP1 PEMT PEX16 PLCG2 PLP2 RUSF1 SEC22B SFXN1 SFXN3 SLC10A1 SLC13A4 SLC18A1 SLC1A1 SLC30A8 SLC35G2 SLC38A7 SLC39A2 SLC39A9 SLC7A1 SLC7A14 SMIM1 STX12 SYK SYNJ2BP SYS1 THBD TMEM107 TMEM120B TMEM140 TMEM14B TMEM179B TMEM19 TMEM218 TMEM31 TPRG1 TSPO TSPO2 UBE2J1 UBIAD1 UNC50 UNC93A VAMP1 YIF1A YIPF4 YIPF6
Entrez ID		7056	2207
HPRD ID		01764	00916
Ensembl ID		ENSG00000178726	ENSG00000158869
Uniprot IDs		P07204	P30273
PDB IDs		1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS 5TO3 7T4R	7Q5T 8YVU 8YWA
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Lipid Transport Protein Binding Organic Hydroxy Compound Transport Identical Protein Binding Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Endoplasmic Reticulum Positive Regulation Of Protein Localization To Cell Surface Very-low-density Lipoprotein Particle	Membrane Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Endoplasmic Reticulum Membrane Protein Binding Monoatomic Ion Transport Transmembrane Transport Hypersensitivity Immune Response-regulating Signaling Pathway Regulation Of Platelet Activation Amino Acid Transmembrane Transport Plasma Membrane Mitochondrial Membrane Acute Inflammatory Response To Antigenic Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway IgG Receptor Activity Amino Acid Transport Endoplasmic Reticulum Regulation Of Tumor Necrosis Factor Production Organic Cation Transport Fc-epsilon Receptor Signaling Pathway Antibody-dependent Cellular Cytotoxicity Monoatomic Cation Transport Zinc Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Zinc Ion Transport Metal Ion Transport Lipid Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Production Low-affinity IgG Receptor Activity Immune Receptor Activity Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Monoatomic Ion Transmembrane Transporter Activity Inflammatory Response To Antigenic Stimulus IgG Binding COPII-coated ER To Golgi Transport Vesicle Monoatomic Ion Transmembrane Transport Immunoglobulin Mediated Immune Response Regulation Of Cytokine Production Involved In Immune Response Serine Import Into Mitochondrion B Cell Mediated Immunity Regulation Of Production Of Molecular Mediator Of Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Organic Anion Transport Neutral Amino Acid Transport Regulation Of Secretion Nuclear Inner Membrane Inflammatory Response Follicular B Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?