THBD and PROC

Number of citations of the paper that reports this interaction (PMID 11106601)
8

Data Source:
HPRD (in vitro)

		THBD	PROC
Gene Name		thrombomodulin	protein C (inactivator of coagulation factors Va and VIIIa)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Extracellular Region Endoplasmic Reticulum Lumen Golgi Lumen
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Signal Transduction Female Pregnancy Blood Coagulation Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Response To Lipopolysaccharide Leukocyte Migration Response To CAMP Negative Regulation Of Fibrinolysis	Proteolysis Blood Coagulation Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Blood Coagulation Negative Regulation Of Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Leukocyte Migration
Pathways		Common Pathway Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall	Common Pathway Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Intrinsic Pathway Post-translational protein modification Removal of aminoterminal propeptides from gamma-carboxylated proteins Gamma-carboxylation of protein precursors Formation of Fibrin Clot (Clotting Cascade) Gamma carboxylation, hypusine formation and arylsulfatase activation Cell surface interactions at the vascular wall Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Drotrecogin alfa Ibuprofen	Menadione Sodium Tetradecyl Sulfate
Diseases
GWAS			Protein C levels ( 20802025)
Protein-Protein Interactions		5 interactors: F2 PF4 PROC PSENEN SERPINA5	13 interactors: CP CSNK2B F2 F5 F8 GGCX PF4 PROCR PROS1 SERPINA5 SERPINB6 THBD TK1
Entrez ID		7056	5624
HPRD ID		01764	01466
Ensembl ID		ENSG00000178726	ENSG00000115718
Uniprot IDs		P07204	B4DPQ7 P04070
PDB IDs		1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS	1AUT 1LQV 1PCU 2PCT 3F6U 3JTC 4DT7
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Peptidyl-glutamic Acid Carboxylation Response To Wounding Leukocyte Migration Locomotion Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Movement Of Cell Or Subcellular Component Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Cell Migration Cell Motility Negative Regulation Of Cytolysis Platelet Activation Post-translational Protein Modification Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Response To Stress Negative Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Regulation Of Apoptotic Process Negative Regulation Of Protein Processing Proteolysis Positive Regulation Of Macrophage Differentiation Amyloid Precursor Protein Catabolic Process Regulation Of Cell Death Regulation Of Protein Processing Regulation Of Fibrinolysis Positive Regulation Of CAMP-mediated Signaling Inflammatory Response Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Fusion Of Sperm To Egg Plasma Membrane Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Megakaryocyte Differentiation Plasma Membrane Fusion Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Regulation Of CAMP-mediated Signaling Notch Receptor Processing Response To Stimulus Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Coagulation Platelet Activation Platelet Degranulation Leukocyte Migration Negative Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Response To Stress Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Blood Coagulation Regulation Of Fibrinolysis Exocytosis Locomotion Negative Regulation Of Proteolysis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Protein Processing Negative Regulation Of Platelet Activation Regulation Of Wound Healing Regulation Of Protein Processing Cell Migration Movement Of Cell Or Subcellular Component Cell Motility Fibrinolysis Secretion By Cell Regulation Of Platelet Activation Positive Regulation Of Blood Coagulation Post-translational Protein Modification Acute-phase Response Positive Regulation Of Coagulation Response To Stimulus Secretion Positive Regulation Of Wound Healing Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis Negative Regulation Of Peptidase Activity Fetal Process Involved In Parturition Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Acute Inflammatory Response Negative Regulation Of Protein Metabolic Process Regulation Of Endopeptidase Activity Skeletal Muscle Cell Proliferation Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity
Tagcloud ?		acat acyltransferase alox5ap arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thrombomodulin	a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang
Tagcloud (Difference) ?		acat acyltransferase alox5ap arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thrombomodulin	a1 acad binds comai defective duncan hnrnp hnrnps interfering lai leader li linking mapped mhv natl participate pentanucleotide polypyrimidine ptb repeats ribonucleoprotein sci shuttles splicing strand ucuaa usa zhang
Tagcloud (Intersection) ?