THBD and PHF24

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		THBD	PHF24
Description		thrombomodulin	PHD finger protein 24
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GO Annotations	Cellular Component	Extracellular Space Vacuolar Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Apicolateral Plasma Membrane Serine-type Endopeptidase Complex	Nucleus Cytoplasm Synaptic Vesicle Membrane Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding Signaling Receptor Activity	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Proteolysis Female Pregnancy Blood Coagulation Hemostasis Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Zymogen Activation Response To Lipopolysaccharide Negative Regulation Of Coagulation Response To CAMP Negative Regulation Of Fibrinolysis Blood Coagulation, Common Pathway	Gamma-aminobutyric Acid Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of DNA-templated Transcription Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall
Drugs		Drotrecogin alfa Ibuprofen Dexibuprofen
Diseases		Inherited thrombophilia
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Lung function (FVC) in asthma ( 32989782) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Venous thromboembolism ( 26888256)
Interacting Genes		33 interacting genes: AIG1 APOC2 APOC4 AQP6 CD79A CIDEB CYBC1 EBP ERGIC3 F2 FAM209A FCER1G GPR152 GPX8 KIR2DL3 LMNA MMGT1 MTIF3 MUC1 PDZK1IP1 PF4 PHF24 PROC PSENEN RHBDD2 SERPINA5 SLC10A6 SLC19A3 SLC35H1 TMEM14B TMEM35A TMEM86B TMX2	5 interacting genes: GNAI3 PFDN5 THBD TRIM35 ZNF552
Entrez ID		7056	23349
HPRD ID		01764	19412
Ensembl ID		ENSG00000178726	ENSG00000122733
Uniprot IDs		P07204	Q9UPV7
PDB IDs		1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS 5TO3 7T4R	1WIL 5XHT
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Negative Regulation Of Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Lipid Transport Protein Binding Organic Hydroxy Compound Transport Identical Protein Binding Negative Regulation Of Wound Healing Regulation Of Hemostasis Regulation Of Blood Coagulation Endoplasmic Reticulum Positive Regulation Of Protein Localization To Cell Surface Very-low-density Lipoprotein Particle	RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly Blood Coagulation, Common Pathway
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