PINK1 and CRLS1

Number of citations of the paper that reports this interaction (PMID 24703837)
2

Data Source:
BioGRID (pull down)

		PINK1	CRLS1
Gene Name		PTEN induced putative kinase 1	cardiolipin synthase 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Membrane Axon Integral Component Of Mitochondrial Outer Membrane TORC2 Complex Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection	Mitochondrial Inner Membrane Integral Component Of Membrane
	Molecular Function	Magnesium Ion Binding Protease Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Calcium-dependent Protein Kinase Activity Kinase Activity Peptidase Activator Activity Ubiquitin Protein Ligase Binding Protein Kinase B Binding C3HC4-type RING Finger Domain Binding	Phosphotransferase Activity, For Other Substituted Phosphate Groups
	Biological Process	Mitochondrion Degradation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Response To Stress Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Peptidase Activity Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Respiratory Electron Transport Chain Regulation Of Protein Ubiquitination Activation Of Protein Kinase B Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Dopamine Secretion Cellular Response To Oxidative Stress Positive Regulation Of Protein Dephosphorylation Intracellular Signal Transduction Peptidyl-serine Autophosphorylation TORC2 Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Negative Regulation Of JNK Cascade Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Cellular Response To Hypoxia Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Synaptic Vesicle Transport Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Mitochondrion Degradation Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Phospholipid Metabolic Process Cardiolipin Biosynthetic Process Phosphatidylglycerol Acyl-chain Remodeling Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process
Pathways			Acyl chain remodelling of PG Metabolism of lipids and lipoproteins Phospholipid metabolism Glycerophospholipid biosynthesis Synthesis of CL
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BAG2 CRLS1 EED FBXO7 MAP3K7 MARK2 PARK7 PGAM5 SNCA SNCAIP TRAF6 UBC UBE2M	4 interactors: FBXO15 MCM6 MCM7 PINK1
Entrez ID		65018	54675
HPRD ID		10514	12187
Ensembl ID		ENSG00000158828	ENSG00000088766
Uniprot IDs		Q9BXM7	Q9UJA2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Cellular Response To Growth Factor Stimulus Cell Death Death Toll-like Receptor 4 Signaling Pathway Response To Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Oxidative Phosphorylation JNK Cascade Dopamine Transport Cellular Metabolic Process Regulation Of Cellular Respiration Neurotransmitter Uptake Synaptic Transmission, Dopaminergic Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway	DNA Unwinding Involved In DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation DNA Duplex Unwinding DNA Geometric Change DNA-dependent DNA Replication Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication DNA Conformation Change Positive Regulation Of Cellular Respiration Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Cellular Response To Hypoxia Positive Regulation Of Dopamine Secretion Peptidyl-serine Autophosphorylation Negative Regulation Of Oxidative Stress-induced Neuron Death TORC2 Signaling Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Mitochondrial Fission Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Oxidative Phosphorylation Regulation Of Mitochondrion Degradation Positive Regulation Of Catecholamine Secretion Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Cellular Respiration Regulation Of Mitochondrial Fission Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Organelle Organization Mitotic Cell Cycle Process Positive Regulation Of Protein Dephosphorylation TOR Signaling Regulation Of Dopamine Secretion Mitotic Cell Cycle Cellular Response To Toxic Substance Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Oxidative Stress-induced Cell Death Response To Epidermal Growth Factor Mitochondrion Degradation
Tagcloud ?		aberration afford atpase controlling dramatic ectopic entry fission irreversible maturation mediates nervous neurodegeneration neurodegenerative neurogenesis neuronal oxidant oxidative physiologically precise premature programmed pten rationale reproted restores suppressing thapsigargin ubiquitously
Tagcloud (Difference) ?		aberration afford atpase controlling dramatic ectopic entry fission irreversible maturation mediates nervous neurodegeneration neurodegenerative neurogenesis neuronal oxidant oxidative physiologically precise premature programmed pten rationale reproted restores suppressing thapsigargin ubiquitously
Tagcloud (Intersection) ?