PINK1 and PARK7

Number of citations of the paper that reports this interaction (PMID 19229105)
70

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		PINK1	PARK7
Gene Name		PTEN induced putative kinase 1	parkinson protein 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Cytoskeleton Membrane Axon Integral Component Of Mitochondrial Outer Membrane TORC2 Complex Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Respiratory Chain Complex I Mitochondrial Intermembrane Space Mitochondrial Matrix Cytosol Plasma Membrane PML Body Axon Cell Body Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Magnesium Ion Binding Protease Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Calcium-dependent Protein Kinase Activity Kinase Activity Peptidase Activator Activity Ubiquitin Protein Ligase Binding Protein Kinase B Binding C3HC4-type RING Finger Domain Binding	Core Promoter Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity MRNA Binding Receptor Binding Copper Ion Binding Protein Binding Transcription Factor Binding Peptidase Activity Superoxide Dismutase Copper Chaperone Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Glyoxalase III Activity Enzyme Binding Kinase Binding Cytokine Binding Tyrosine 3-monooxygenase Activator Activity L-dopa Decarboxylase Activator Activity Identical Protein Binding Protein Homodimerization Activity Small Protein Activating Enzyme Binding Ubiquitin-like Protein Conjugating Enzyme Binding Mercury Ion Binding Androgen Receptor Binding Peroxiredoxin Activity Repressing Transcription Factor Binding Scaffold Protein Binding Cupric Ion Binding Cuprous Ion Binding Ubiquitin-specific Protease Binding Glyoxalase (glycolic Acid-forming) Activity
	Biological Process	Mitochondrion Degradation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Response To Stress Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Peptidase Activity Phosphorylation Protein Ubiquitination Peptidyl-serine Phosphorylation Respiratory Electron Transport Chain Regulation Of Protein Ubiquitination Activation Of Protein Kinase B Activity Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Dopamine Secretion Cellular Response To Oxidative Stress Positive Regulation Of Protein Dephosphorylation Intracellular Signal Transduction Peptidyl-serine Autophosphorylation TORC2 Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Complex Assembly Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Negative Regulation Of JNK Cascade Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Cellular Response To Hypoxia Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Toxic Substance Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Synaptic Vesicle Transport Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Mitochondrion Degradation Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Proteolysis Protein Deglycosylation Autophagy Inflammatory Response Mitochondrion Organization Ras Protein Signal Transduction Single Fertilization Adult Locomotory Behavior Detoxification Of Copper Ion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Enzyme Active Site Formation Via L-cysteine Sulfinic Acid Methylglyoxal Catabolic Process To D-lactate Lactate Biosynthetic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Sumoylation Cellular Response To Oxidative Stress Cellular Response To Glyoxal Hydrogen Peroxide Metabolic Process Negative Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of TRAIL Receptor Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Glycolate Biosynthetic Process Negative Regulation Of Protein Export From Nucleus Regulation Of Inflammatory Response Detoxification Of Mercury Ion Protein Stabilization Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Ubiquitin-protein Transferase Activity Dopamine Uptake Involved In Synaptic Transmission Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein Kinase B Signaling Membrane Depolarization Membrane Hyperpolarization Negative Regulation Of Cell Death Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Hydrogen Peroxide Positive Regulation Of Protein Homodimerization Activity Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Neuron Death Positive Regulation Of Superoxide Dismutase Activity Negative Regulation Of Protein Acetylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Fibril Organization Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Negative Regulation Of Death-inducing Signaling Complex Assembly Negative Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of TRAIL-activated Apoptotic Signaling Pathway Positive Regulation Of Pyrroline-5-carboxylate Reductase Activity Positive Regulation Of Tyrosine 3-monooxygenase Activity Positive Regulation Of Dopamine Biosynthetic Process Glyoxal Catabolic Process Positive Regulation Of L-dopa Biosynthetic Process Positive Regulation Of L-dopa Decarboxylase Activity Negative Regulation Of Oxidative Stress-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-specific Protease Activity Positive Regulation Of Oxidative Phosphorylation Uncoupler Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Androgen Receptor Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways
Drugs			Double Oxidized Cysteine
Diseases
GWAS			Celiac disease ( 20190752) Ulcerative colitis ( 21297633)
Protein-Protein Interactions		13 interactors: BAG2 CRLS1 EED FBXO7 MAP3K7 MARK2 PARK7 PGAM5 SNCA SNCAIP TRAF6 UBC UBE2M	20 interactors: BAX BBS1 BCL2L1 CASP8 CSN1S1 DAXX EFCAB6 FADD GOPC HIPK1 NDUFA4 PIAS2 PINK1 PPP2R1A PPP2R1B PTEN SOD1 SUMO1 UBA2 UBE2I
Entrez ID		65018	11315
HPRD ID		10514	03961
Ensembl ID		ENSG00000158828	ENSG00000116288
Uniprot IDs		Q9BXM7	K7ELW0 Q99497
PDB IDs			1J42 1P5F 1PDV 1PDW 1PE0 1Q2U 1SOA 1UCF 2OR3 2R1T 2R1U 2R1V 2RK3 2RK4 2RK6 3B36 3B38 3B3A 3BWE 3CY6 3CYF 3CZ9 3CZA 3EZG 3F71 3SF8
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Activation Of Protein Kinase Activity Positive Regulation Of Transferase Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process Toll-like Receptor 2 Signaling Pathway Regulation Of Phosphorus Metabolic Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Catalytic Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Programmed Cell Death Regulation Of Catalytic Activity Positive Regulation Of Transcription Regulatory Region DNA Binding Cellular Response To Growth Factor Stimulus Cell Death Death Toll-like Receptor 4 Signaling Pathway Response To Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Oxidative Phosphorylation JNK Cascade Dopamine Transport Cellular Metabolic Process Regulation Of Cellular Respiration Neurotransmitter Uptake Synaptic Transmission, Dopaminergic Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway	Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Sumoylation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Membrane Potential Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Positive Regulation Of Proteolysis Regulation Of Cell Death Regulation Of Lymphocyte Apoptotic Process Apoptotic Signaling Pathway Regulation Of Catalytic Activity Regulation Of Mitochondrion Organization Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process TRAIL-activated Apoptotic Signaling Pathway Regulation Of Membrane Potential Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Neuron Death Positive Regulation Of Protein Metabolic Process Membrane Organization Viral Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Peptidase Activity Negative Regulation Of Programmed Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cell Death Regulation Of Metabolic Process Organelle Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Cellular Protein Metabolic Process Neuron Apoptotic Process Response To Toxic Substance Regulation Of Proteolysis Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization
Tagcloud ?		aberration afford atpase controlling dramatic ectopic entry fission irreversible maturation mediates nervous neurodegeneration neurodegenerative neurogenesis neuronal oxidant oxidative physiologically precise premature programmed pten rationale reproted restores suppressing thapsigargin ubiquitously	account alleviates antioxidant clear completely conversely deficiency dj effectively elusive exerts familial hypersensitivity hypersensitizes importantly interacting interestingly neurons oxidative paradigm paraoxonase parkinson partly pd phenylpyridinium pon2 protects rescues stress
Tagcloud (Difference) ?		aberration afford atpase controlling dramatic ectopic entry fission irreversible maturation mediates nervous neurodegeneration neurodegenerative neurogenesis neuronal oxidant physiologically precise premature programmed pten rationale reproted restores suppressing thapsigargin ubiquitously	account alleviates antioxidant clear completely conversely deficiency dj effectively elusive exerts familial hypersensitivity hypersensitizes importantly interacting interestingly neurons paradigm paraoxonase parkinson partly pd phenylpyridinium pon2 protects rescues stress
Tagcloud (Intersection) ?		oxidative