PINK1 and NEAT1

Number of citations of the paper that reports this interaction (PubMedID 32140098)
39

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		PINK1	NEAT1
Description		PTEN induced kinase 1	nuclear paraspeckle assembly transcript 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cytosol Cytoskeleton Membrane Axon Growth Cone Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection	RISC Complex Paraspeckles
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Peptidase Activator Activity Transferase Activity Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase B Binding Protein-containing Complex Binding Metal Ion Binding C3HC4-type RING Finger Domain Binding Protein Serine Kinase Activity	MiRNA Binding Chromatin-protein Adaptor Activity Molecular Condensate Scaffold Activity MiRNA Inhibitor Activity Via Base-pairing RISC Complex Binding
	Biological Process	Autophagy Of Mitochondrion Mitophagy Regulation Of Oxidative Phosphorylation Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Dopamine Secretion Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Protein Ubiquitination Respiratory Electron Transport Chain Hemopoiesis Positive Regulation Of Cell Migration Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Positive Regulation Of Catecholamine Secretion Cellular Response To Oxidative Stress Intracellular Signal Transduction TORC2 Signaling Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Catecholamine Secretion Protein Stabilization Establishment Of Localization In Cell Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Hypoxia Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Cellular Response To Toxic Substance Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Mitophagy Regulation Of Synaptic Vesicle Transport Negative Regulation Of Autophagosome Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Cristae Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Free Ubiquitin Chain Polymerization Cellular Response To Hydrogen Sulfide Positive Regulation Of Type 2 Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	LncRNA-mediated Post-transcriptional Gene Silencing Chromatin Organization Regulation Of MRNA Export From Nucleus Nuclear Body Organization MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Inflammatory Response Positive Regulation Of Synoviocyte Proliferation Positive Regulation Of MiRNA Catabolic Process
Pathways		PINK1-PRKN Mediated Mitophagy FOXO-mediated transcription of cell death genes
Drugs
Diseases		Parkinson's disease (PD)
GWAS		Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proportion of activated microglia (inferior temporal cortex) ( 30679421)	Acne (severe) ( 24927181) Glaucoma (primary open-angle) ( 29891935) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		23 interacting genes: APPL2 BAG2 BAG5 BCL2L1 CRLS1 DNM1L FBXO7 HSH2D MAP3K7 MARK2 NEAT1 PARK7 RNF31 SIAH1 SIAH3 SNCAIP SPATC1L TGM2 TOMM20 TOMM70 TRAF6 UBC UBE2M	12 interacting genes: CTSD EGR1 GAR1 HACD3 MPC2 NEDD4L PINK1 RIMBP2 TRAF6 TUBB4A TUBB4B USP9X
Entrez ID		65018	283131
HPRD ID		10514
Ensembl ID		ENSG00000158828	ENSG00000245532
Uniprot IDs		Q9BXM7
PDB IDs		9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Mitochondrion Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Identical Protein Binding Mitochondrial Outer Membrane Regulation Of Inclusion Body Assembly Regulation Of Protein Stability Linear Polyubiquitin Binding Protein Targeting To Mitochondrion Regulation Of Programmed Cell Death Ubiquitin Conjugating Enzyme Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrion Organization Ubiquitin-protein Transferase Activity Mitochondrion Targeting Sequence Binding Protein Localization To Mitochondrion Positive Regulation Of Defense Response Interleukin-17A-mediated Signaling Pathway Regulation Of Protein Targeting To Mitochondrion Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway TOM Complex Negative Regulation Of Intracellular Signal Transduction Regulation Of Autophagy Of Mitochondrion Interleukin-33-mediated Signaling Pathway Regulation Of Apoptotic Process Mitochondrial Outer Membrane Translocase Complex Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Positive Regulation Of Catabolic Process CD40 Signaling Pathway Positive Regulation Of Autophagy TRIF-dependent Toll-like Receptor Signaling Pathway CD40 Receptor Complex Regulation Of Mitochondrial Membrane Potential Regulation Of Intracellular Signal Transduction Protein Metabolic Process Positive Regulation Of JUN Kinase Activity Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Establishment Of Protein Localization To Mitochondrion Protein Insertion Into Mitochondrial Outer Membrane Regulation Of Protein Localization Negative Regulation Of Protein Ubiquitination Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway	Receptor Metabolic Process Protein Kinase B Binding Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Recycling Regulation Of Protein Localization Interleukin-1-mediated Signaling Pathway Positive Regulation Of Post-translational Protein Modification Mitochondrial Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Organelle Organization Antigen Processing And Presentation Of Exogenous Antigen Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Regulation Of Biological Quality Regulation Of Post-translational Protein Modification Cellular Response To Interleukin-8 Protein Ubiquitination K11-linked Deubiquitinase Activity Canonical NF-kappaB Signal Transduction Antigen Processing And Presentation Of Peptide Antigen Insulin Catabolic Process Aspartic-type Peptidase Activity Autophagosome Organization Cysteine-type Endopeptidase Activity Antigen Processing And Presentation Autophagosome Assembly Insulin Receptor Recycling Positive Regulation Of Protein Metabolic Process Hemi-methylated DNA-binding Enzyme Binding Positive Regulation Of Protein Modification Process Cellular Response To Mycophenolic Acid Circadian Temperature Homeostasis Glomerular Mesangial Cell Proliferation Cellular Response To Heparin Regulation Of Progesterone Biosynthetic Process Response To Ischemia BMP Signaling Pathway Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Regulation Of Protein Stability Structural Constituent Of Cytoskeleton Internode Region Of Axon Intercellular Bridge Negative Regulation Of Sodium Ion Import Across Plasma Membrane
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