PINK1 and HSH2D

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		PINK1	HSH2D
Description		PTEN induced kinase 1	hematopoietic SH2 domain containing
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GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Cytosol Cytoskeleton Membrane Axon Growth Cone Cell Body Perinuclear Region Of Cytoplasm Lewy Body Astrocyte Projection	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protease Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Peptidase Activator Activity Transferase Activity Kinase Binding Ubiquitin Protein Ligase Binding Protein Kinase B Binding Protein-containing Complex Binding Metal Ion Binding C3HC4-type RING Finger Domain Binding Protein Serine Kinase Activity	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Autophagy Of Mitochondrion Mitophagy Regulation Of Oxidative Phosphorylation Response To Ischemia Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Autophagy Response To Stress Response To Oxidative Stress Mitochondrion Organization Regulation Of Hydrogen Peroxide Metabolic Process Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Dopamine Secretion Macroautophagy Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Protein Ubiquitination Respiratory Electron Transport Chain Hemopoiesis Positive Regulation Of Cell Migration Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Positive Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Dopamine Secretion Positive Regulation Of Catecholamine Secretion Cellular Response To Oxidative Stress Intracellular Signal Transduction TORC2 Signaling Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of JNK Cascade Catecholamine Secretion Protein Stabilization Establishment Of Localization In Cell Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Hypoxia Establishment Of Protein Localization To Mitochondrion Maintenance Of Protein Location In Mitochondrion Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Mitochondrial Fission Cellular Response To Toxic Substance Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Mitophagy Regulation Of Synaptic Vesicle Transport Negative Regulation Of Autophagosome Assembly Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Autophagy Of Mitochondrion Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Positive Regulation Of Cristae Formation Positive Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Free Ubiquitin Chain Polymerization Cellular Response To Hydrogen Sulfide Positive Regulation Of Type 2 Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of ATP Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of B Cell Apoptotic Process Signal Transduction T Cell Activation Negative Regulation Of Mitochondrial Depolarization
Pathways		PINK1-PRKN Mediated Mitophagy FOXO-mediated transcription of cell death genes
Drugs
Diseases		Parkinson's disease (PD)
GWAS		Household income (MTAG) ( 31844048) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proportion of activated microglia (inferior temporal cortex) ( 30679421)	Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		23 interacting genes: APPL2 BAG2 BAG5 BCL2L1 CRLS1 DNM1L FBXO7 HSH2D MAP3K7 MARK2 NEAT1 PARK7 RNF31 SIAH1 SIAH3 SNCAIP SPATC1L TGM2 TOMM20 TOMM70 TRAF6 UBC UBE2M	21 interacting genes: AR CNMD CRK EGFR ERBB2 ERBB3 ERBB4 FES GAB1 KIT LDHAL6B MET MPP3 OLIG1 PIK3R3 PINK1 PLPP6 RBP7 TNK2 TSC1 TSG101
Entrez ID		65018	84941
HPRD ID		10514	12219
Ensembl ID		ENSG00000158828	ENSG00000196684
Uniprot IDs		Q9BXM7	Q96JZ2
PDB IDs		9EIH 9EII 9EIJ	2CS0
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Mitochondrion Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Autophagy Identical Protein Binding Mitochondrial Outer Membrane Regulation Of Inclusion Body Assembly Regulation Of Protein Stability Linear Polyubiquitin Binding Protein Targeting To Mitochondrion Regulation Of Programmed Cell Death Ubiquitin Conjugating Enzyme Binding Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrion Organization Ubiquitin-protein Transferase Activity Mitochondrion Targeting Sequence Binding Protein Localization To Mitochondrion Positive Regulation Of Defense Response Interleukin-17A-mediated Signaling Pathway Regulation Of Protein Targeting To Mitochondrion Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway TOM Complex Negative Regulation Of Intracellular Signal Transduction Regulation Of Autophagy Of Mitochondrion Interleukin-33-mediated Signaling Pathway Regulation Of Apoptotic Process Mitochondrial Outer Membrane Translocase Complex Canonical NF-kappaB Signal Transduction Regulation Of Defense Response Positive Regulation Of Catabolic Process CD40 Signaling Pathway Positive Regulation Of Autophagy TRIF-dependent Toll-like Receptor Signaling Pathway CD40 Receptor Complex Regulation Of Mitochondrial Membrane Potential Regulation Of Intracellular Signal Transduction Protein Metabolic Process Positive Regulation Of JUN Kinase Activity Regulation Of Macroautophagy Regulation Of Protein Ubiquitination Establishment Of Protein Localization To Mitochondrion Protein Insertion Into Mitochondrial Outer Membrane Regulation Of Protein Localization Negative Regulation Of Protein Ubiquitination Regulation Of Cellular Component Organization Regulation Of Apoptotic Signaling Pathway Protein Modification Process MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway	Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Basal Plasma Membrane ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Receptor Complex Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Developmental Process Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Ubiquitin Protein Ligase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Motility ERBB3:ERBB2 Complex Positive Regulation Of Phosphate Metabolic Process Animal Organ Development Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Anatomical Structure Morphogenesis Positive Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Protein Modification Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Phosphorylation Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Regulation Of Cell Population Proliferation Regulation Of Phosphorylation Regulation Of Cell Migration Positive Regulation Of Phosphorylation ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Cell Population Proliferation
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