MAP2K1 and GRB10

  • Number of citations of the paper that reports this interaction (PMID 9553107)
  • 14
  • Data Source:
  • BioGRID (affinity chromatography technology, affinity chromatography technology)
  • HPRD (in vitro, two hybrid, in vivo)

MAP2K1

GRB10

Gene Name mitogen-activated protein kinase kinase 1 growth factor receptor-bound protein 10
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Acute lymphoblastic leukemia (childhood) ( 23512250)
  • Bone mineral density ( 22504420)
  • Fasting glucose-related traits (interaction with BMI) ( 22581228)
  • Systemic sclerosis ( 21779181)
Protein-Protein Interactions 41 interactors: ARAF BANP BIRC6 BRAF CASP9 CDK5 CPNE1 CPNE4 EGFR ELK1 EP300 GRB10 HNRNPD HRAS KSR1 KSR2 LAMTOR3 MAP3K4 MAP3K8 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP3 MYC PAK1 PARVA PEBP1 PEBP4 PLK3 PPARG PRKCI PRKCZ RAF1 RPS6KA2 RPS6KA4 SUMO1 TRAF3 TRAF6 TRIB1 WNK1 30 interactors: ABL1 AKT1 APP BCR DOK1 EGFR ELK1 EPHB1 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KDR KIT MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NOA1 PDGFRB RAF1 RET RQCD1 SRC ZDHHC17
Entrez ID 5604 2887
HPRD ID 01469 03312
Ensembl ID ENSG00000106070
Uniprot IDs A4QPA9 B4DFY5 Q02750 Q13322
PDB IDs 1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 1NRV 3HK0
Enriched GO Terms of Interacting Partners?
Tagcloud ?
actionable  adenocarcinomas  akt1  alk  braf  capture  ccdc6  cd74  clip4  deemed  driver  fusions  g719a  genomic  introns  kif5b  nccn  ngs  nras  pack  pik3ca  profiling  rearranged  ret  ros1  socs5  targetable  uniform  v600e 
becomes  carries  cytokine  driven  effector  emerging  exert  fashion  fos  grbir  homology  hybrid  insights  interacting  looked  member  nonreceptor  obscure  phosphorylated  pleckstrin  profoundly  ptks  subfamily  subset  suppresses  syk  tec  tips  turned 
Tagcloud (Difference) ?
actionable  adenocarcinomas  akt1  alk  braf  capture  ccdc6  cd74  clip4  deemed  driver  fusions  g719a  genomic  introns  kif5b  nccn  ngs  nras  pack  pik3ca  profiling  rearranged  ret  ros1  socs5  targetable  uniform  v600e 
becomes  carries  cytokine  driven  effector  emerging  exert  fashion  fos  grbir  homology  hybrid  insights  interacting  looked  member  nonreceptor  obscure  phosphorylated  pleckstrin  profoundly  ptks  subfamily  subset  suppresses  syk  tec  tips  turned 
Tagcloud (Intersection) ?