MAP2K1 and PRKCI

Number of citations of the paper that reports this interaction (PubMedID 10848576)
60

Data Source:
HPRD (in vitro)

		MAP2K1	PRKCI
Description		mitogen-activated protein kinase kinase 1	protein kinase C iota
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Focal Adhesion Cell Cortex Postsynaptic Density Membrane Axon Dendrite Dendrite Cytoplasm Ciliary Basal Body Perikaryon Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane Brush Border Bicellular Tight Junction Cilium Microtubule Cytoskeleton Membrane Apical Plasma Membrane Cell Leading Edge Schmidt-Lanterman Incisure Intercellular Bridge Apical Part Of Cell Extracellular Exosome Tight Junction Schaffer Collateral - CA1 Synapse Glutamatergic Synapse PAR Polarity Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Kinase Activator Activity Small GTPase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding Scaffold Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Regulation Of Vascular Associated Smooth Muscle Contraction Chemotaxis Response To Oxidative Stress Signal Transduction Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Schwann Cell Development Cerebellar Cortex Formation Central Nervous System Neuron Differentiation Neuron Differentiation Keratinocyte Differentiation Positive Regulation Of Cell Migration Thyroid Gland Development Melanosome Transport Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Homotypic Cell-cell Adhesion Endodermal Cell Differentiation ERBB2-ERBB3 Signaling Pathway Myelination Positive Regulation Of MAPK Cascade Type B Pancreatic Cell Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Muscle Contraction Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Insulin-like Growth Factor Receptor Signaling Pathway Golgi Inheritance Thymus Development Response To Axon Injury Regulation Of Axon Regeneration Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Axonogenesis Response To Glucocorticoid Bergmann Glial Cell Differentiation Face Development Lung Morphogenesis Trachea Formation Epithelial Cell Proliferation Involved In Lung Morphogenesis Placenta Blood Vessel Development Labyrinthine Layer Development Triglyceride Homeostasis ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Cellular Senescence Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of ATP Biosynthetic Process	Protein Phosphorylation Protein Targeting To Membrane Cytoskeleton Organization Actin Filament Organization Positive Regulation Of Neuron Projection Development Vesicle-mediated Transport Cell Migration Establishment Of Cell Polarity Cellular Response To Insulin Stimulus Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Notch Signaling Pathway Positive Regulation Of D-glucose Import Secretion Golgi Vesicle Budding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Membrane Organization Cellular Response To Chemical Stress Response To Interleukin-1 Protein Localization To Plasma Membrane Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		MAPK3 (ERK1) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants	Pre-NOTCH Transcription and Translation p75NTR recruits signalling complexes Tight junction interactions KEAP1-NFE2L2 pathway
Drugs		K-252a 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide Cobimetinib Bosutinib (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide Mirdametinib N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE Trametinib Selumetinib Pimasertib	Tamoxifen Staurosporine Bisindolylmaleimide I Dequalinium Benzoyl peroxide Fostamatinib
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Prostate cancer ( 29892016) Testicular germ cell tumor ( 28604728 28604732)	Aspartate aminotransferase levels ( 33547301) Microalbuminuria ( 31511532) Prostate cancer ( 25939597) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31511532 31630189)
Interacting Genes		67 interacting genes: APC ARAF AURKA BANP BAX BIRC6 BMPR1A BRAF BUB1 CASP9 CDH1 CDK5 CDKN2A CPNE1 CPNE4 CTNNA1 EGFR ELK1 EP300 ERBB2 FBXW7 GRB10 HNRNPD HRAS ITCH KAT7 KSR1 KSR2 LAMTOR3 MAP3K4 MAP3K8 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP3 MBP MLH3 MSH6 MYC ODC1 PAK1 PARVA PDGFRL PEBP1 PEBP4 PIK3CA PLEKHF2 PLK3 PPARG PRKCI PRKCZ PTPRJ RAF1 RPS6KA2 RPS6KA4 SMAD2 SRC STK11 TCP11 TGFBR2 TLR2 TRAF3 TRAF6 TRIB1 UBE2I WNK1	51 interacting genes: ADAP1 ANXA1 APP BAD CASK CASP8 CCNT1 CDC42 CDK7 CHUK CTBP1 FABP4 FCGR3A FRS2 FRS3 GAPDH HRAS IKBKG IL1RAP IRAK1 MAP2K1 MAP2K5 MAPT MARK4 MBP MEOX2 NACC1 NFKBIA PARD3 PARD6A PARD6B PARD6G PCM1 PDPK1 PNMA1 RAB2A RAB4A RAC1 RBM14 RHOQ SMG1 SMURF1 SQSTM1 SRC TSC22D1 TTR UBC USP20 VHL YWHAH YWHAZ
Entrez ID		5604	5584
HPRD ID		01469	02105
Ensembl ID		ENSG00000169032	ENSG00000163558
Uniprot IDs		A0A8I5KYS7 A4QPA9 B4DFY5 Q02750	P41743
PDB IDs		1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM 5HZE 5YT3 6NYB 6PP9 6Q0J 6Q0T 6U2G 6V2W 6X2P 6X2S 6X2X 7B3M 7B7R 7B94 7B9L 7F2X 7M0T 7M0U 7M0V 7M0W 7M0X 7M0Y 7M0Z 7MFD 7PQV 7UMB 7XLP 7XNC 8CHF 8DGS 8DGT 8YP4 9AXA 9AXC 9AXH 9AXM 9AXX 9AXY 9AY7 9AYA	1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8 5LI1 5LI9 5LIH 6ILZ 8R3X 8R3Y
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Serine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction MAPK Cascade ATP Binding Regulation Of Cell Communication Regulation Of Signaling Transferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Apoptotic Process Signal Transduction Regulation Of MAPK Cascade Programmed Cell Death Cell Death Intracellular Signaling Cassette Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Cytosol Regulation Of Cellular Localization Regulation Of Cell Population Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Protein Modification Process Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Animal Organ Development Regulation Of Cell Differentiation Phosphorylation Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cellular Component Organization Regulation Of Cell Development Enzyme-linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorylation Immune Response-activating Signaling Pathway	Cytoplasm Cytosol Intracellular Signaling Cassette Positive Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Cellular Localization Intracellular Signal Transduction Immune System Process PAR Polarity Complex Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Signal Transduction Regulation Of Protein Localization Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Immune System Process Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Response To Stress Regulation Of Gene Expression Positive Regulation Of Protein Localization Regulation Of Immune Response Plasma Membrane Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Projection Organization Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Organelle Organization Negative Regulation Of Programmed Cell Death Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Immune System Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Apoptotic Process Establishment Or Maintenance Of Cell Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Cell Projection Organization Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cytokine Production Regulation Of Primary Metabolic Process Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction
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