MAP2K1 and KSR2

Number of citations of the paper that reports this interaction (PubMedID 12975377)
0

Data Source:
HPRD (in vitro)

		MAP2K1	KSR2
Description		mitogen-activated protein kinase kinase 1	kinase suppressor of ras 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Early Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Focal Adhesion Cell Cortex Postsynaptic Density Membrane Axon Dendrite Dendrite Cytoplasm Ciliary Basal Body Perikaryon Perinuclear Region Of Cytoplasm Glutamatergic Synapse	Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Protein Kinase Activator Activity Small GTPase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding Scaffold Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Mitogen-activated Protein Kinase Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	MAPK Cascade Regulation Of Vascular Associated Smooth Muscle Contraction Chemotaxis Response To Oxidative Stress Signal Transduction Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Schwann Cell Development Cerebellar Cortex Formation Central Nervous System Neuron Differentiation Neuron Differentiation Keratinocyte Differentiation Positive Regulation Of Cell Migration Thyroid Gland Development Melanosome Transport Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Homotypic Cell-cell Adhesion Endodermal Cell Differentiation ERBB2-ERBB3 Signaling Pathway Myelination Positive Regulation Of MAPK Cascade Type B Pancreatic Cell Proliferation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Muscle Contraction Positive Regulation Of Ras Protein Signal Transduction Vesicle Transport Along Microtubule Insulin-like Growth Factor Receptor Signaling Pathway Golgi Inheritance Thymus Development Response To Axon Injury Regulation Of Axon Regeneration Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Axonogenesis Response To Glucocorticoid Bergmann Glial Cell Differentiation Face Development Lung Morphogenesis Trachea Formation Epithelial Cell Proliferation Involved In Lung Morphogenesis Placenta Blood Vessel Development Labyrinthine Layer Development Triglyceride Homeostasis ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Golgi Inheritance Cellular Senescence Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Endodermal Cell Differentiation Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of ATP Biosynthetic Process	MAPK Cascade Ras Protein Signal Transduction Calcium-mediated Signaling Positive Regulation Of MAPK Cascade Positive Regulation Of Cold-induced Thermogenesis
Pathways		MAPK3 (ERK1) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by RAF1 mutants	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		K-252a 5-Bromo-N-[(2S)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide Cobimetinib Bosutinib (5S)-4,5-difluoro-6-[(2-fluoro-4-iodophenyl)imino]-N-(2-hydroxyethoxy)cyclohexa-1,3-diene-1-carboxamide 2-[(2-chloro-4-iodophenyl)amino]-N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluorobenzamide Mirdametinib N-(5-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl}-1,3,4-oxadiazol-2-yl)ethane-1,2-diamine 2-[(4-ETHYNYL-2-FLUOROPHENYL)AMINO]-3,4-DIFLUORO-N-(2-HYDROXYETHOXY)BENZAMIDE Trametinib Selumetinib Pimasertib
Diseases		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
GWAS		Prostate cancer ( 29892016) Testicular germ cell tumor ( 28604728 28604732)	Biochemical measures ( 19260141) Body mass index ( 29273807) Body mass index (change over time) in chronic obstructive pulmonary disease ( 28044437) Body size at age 10 ( 32376654) Cerebral amyloid angiopathy in Alzheimer’s disease ( 34020725) Coronary artery disease ( 26343387) Daytime nap ( 33568662) Depression ( 27089181) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Endometriosis ( 23472165) Hip circumference adjusted for BMI ( 28552196) Late-onset Alzheimer's disease ( 27770636) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Pursuit maintenance gain ( 29064472) Pursuit maintenance gain in psychotic disorders ( 29064472) Refractive error ( 32231278) Spontaneous preterm birth with premature rupture of membranes ( 31194736) Type 2 diabetes ( 30718926 32499647 30297969) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		67 interacting genes: APC ARAF AURKA BANP BAX BIRC6 BMPR1A BRAF BUB1 CASP9 CDH1 CDK5 CDKN2A CPNE1 CPNE4 CTNNA1 EGFR ELK1 EP300 ERBB2 FBXW7 GRB10 HNRNPD HRAS ITCH KAT7 KSR1 KSR2 LAMTOR3 MAP3K4 MAP3K8 MAPK1 MAPK14 MAPK3 MAPK8 MAPK8IP3 MBP MLH3 MSH6 MYC ODC1 PAK1 PARVA PDGFRL PEBP1 PEBP4 PIK3CA PLEKHF2 PLK3 PPARG PRKCI PRKCZ PTPRJ RAF1 RPS6KA2 RPS6KA4 SMAD2 SRC STK11 TCP11 TGFBR2 TLR2 TRAF3 TRAF6 TRIB1 UBE2I WNK1	7 interacting genes: CYSRT1 KRTAP10-8 MAP2K1 MAPK1 MAPK3 PJA2 RAF1
Entrez ID		5604	283455
HPRD ID		01469	13952
Ensembl ID		ENSG00000169032	ENSG00000171435
Uniprot IDs		A0A8I5KYS7 A4QPA9 B4DFY5 Q02750	Q6VAB6
PDB IDs		1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM 5HZE 5YT3 6NYB 6PP9 6Q0J 6Q0T 6U2G 6V2W 6X2P 6X2S 6X2X 7B3M 7B7R 7B94 7B9L 7F2X 7M0T 7M0U 7M0V 7M0W 7M0X 7M0Y 7M0Z 7MFD 7PQV 7UMB 7XLP 7XNC 8CHF 8DGS 8DGT 8YP4 9AXA 9AXC 9AXH 9AXM 9AXX 9AXY 9AY7 9AYA	2Y4I 5KKR 7JUQ 7JUR 7JUS 7JUT 7JUU 7JUV 7UMB
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Protein Serine Kinase Activity Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction MAPK Cascade ATP Binding Regulation Of Cell Communication Regulation Of Signaling Transferase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Apoptotic Process Signal Transduction Regulation Of MAPK Cascade Programmed Cell Death Cell Death Intracellular Signaling Cassette Nucleotide Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Cytosol Regulation Of Cellular Localization Regulation Of Cell Population Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Localization Regulation Of Protein Modification Process Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Animal Organ Development Regulation Of Cell Differentiation Phosphorylation Regulation Of Developmental Process Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Cellular Component Organization Regulation Of Cell Development Enzyme-linked Receptor Protein Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorylation Immune Response-activating Signaling Pathway	ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Schwann Cell Development Face Development ERBB2 Signaling Pathway Regulation Of Golgi Inheritance Thyroid Gland Development Insulin-like Growth Factor Receptor Signaling Pathway Trachea Formation Thymus Development Bergmann Glial Cell Differentiation Glial Cell Development ERBB Signaling Pathway Regulation Of Golgi Organization Myelination Axon Ensheathment Regulation Of Early Endosome To Late Endosome Transport Hematopoietic Or Lymphoid Organ Development Pseudopodium Animal Organ Formation Lung Morphogenesis Astrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Interleukin-34-mediated Signaling Pathway MAPK Cascade ERK1 And ERK2 Cascade Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Regulation Of MAPK Cascade Gland Development Cardiac Neural Crest Cell Development Involved In Heart Development Insulin Receptor Signaling Pathway Ciliary Basal Body Outer Ear Morphogenesis Protein Serine Kinase Activity Glial Cell Differentiation Protein Serine/threonine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade MAP Kinase Activity Type B Pancreatic Cell Proliferation Protein Kinase Activity Late Endosome Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuroinflammatory Response Stress-activated MAPK Cascade Epithelial Cell Proliferation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Macrophage Migration
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