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TFCP2 and MAPK8
Number of citations of the paper that reports this interaction (PMID
15857981
)
9
Data Source:
BioGRID
(enzymatic study)
TFCP2
MAPK8
Gene Name
transcription factor CP2
mitogen-activated protein kinase 8
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cellular_component
Nucleus
Nucleus
Nucleoplasm
Mitochondrion
Cytosol
Molecular Function
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Sequence-specific DNA Binding
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
Protein Binding
ATP Binding
Enzyme Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Biological Process
Transcription, DNA-templated
Regulation Of Transcription From RNA Polymerase II Promoter
Ossification
Toll-like Receptor Signaling Pathway
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Response To Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Positive Regulation Of Gene Expression
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Regulation Of Histone Deacetylation
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Toll-like Receptor 2 Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor 5 Signaling Pathway
Toll-like Receptor 9 Signaling Pathway
Toll-like Receptor 10 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Response To Cadmium Ion
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Stress-activated MAPK Cascade
Cellular Response To Hydrogen Peroxide
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Response To Nitric Oxide
Positive Regulation Of Deacetylase Activity
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Determination Of Dorsal Identity
Pathways
Toll Like Receptor 7/8 (TLR7/8) Cascade
Cellular Senescence
Activation of BH3-only proteins
FCERI mediated MAPK activation
Toll Like Receptor TLR6:TLR2 Cascade
Activation of BMF and translocation to mitochondria
Activated TLR4 signalling
Toll Like Receptor TLR1:TLR2 Cascade
Activation of the AP-1 family of transcription factors
MyD88 cascade initiated on plasma membrane
Toll Like Receptor 5 (TLR5) Cascade
Programmed Cell Death
MyD88 dependent cascade initiated on endosome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor 9 (TLR9) Cascade
Intrinsic Pathway for Apoptosis
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Innate Immune System
Signalling by NGF
Cell death signalling via NRAGE, NRIF and NADE
TRIF-mediated TLR3/TLR4 signaling
MAP kinase activation in TLR cascade
p75 NTR receptor-mediated signalling
MyD88-independent cascade
Toll Like Receptor 2 (TLR2) Cascade
Toll-Like Receptors Cascades
Toll Like Receptor 10 (TLR10) Cascade
DSCAM interactions
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
Activation of BIM and translocation to mitochondria
Toll Like Receptor 3 (TLR3) Cascade
Toll Like Receptor 4 (TLR4) Cascade
NRAGE signals death through JNK
Fc epsilon receptor (FCERI) signaling
MAPK targets/ Nuclear events mediated by MAP kinases
Drugs
Diseases
GWAS
Protein-Protein Interactions
62 interactors:
ADPRH
APBB1
ASAP3
BAG6
C19orf73
CA1
CASP8
CBX8
CCDC94
CDC73
COIL
DNAJC27
DNAJC5B
DPH1
E2F8
EAF1
EIF5B
EPHA10
FAM64A
FANCL
FARS2
FBXL18
GPANK1
HDAC1
HDAC2
IRAK1BP1
KIAA1598
MAPK1
MAPK14
MAPK8
MOB3C
MORF4L1
MRPL11
MRPL40
MVP
NABP1
NFE4
NOM1
NPEPL1
PHF1
PITPNM1
PLCB1
POLL
POLR3GL
PPIG
PPP1R1B
PPP3R2
PSMD5
RBMS1
RNF2
SDCBP
SIN3A
STMN2
SUMO1
TCEA2
TDRD1
TRAPPC12
TSPAN12
UBP1
YY1
ZCCHC10
ZCCHC12
134 interactors:
AIMP1
APLP2
APP
ATF2
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
C11orf57
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
DUSP8
EEF2K
ELK1
ELK3
ELK4
EP300
ETV1
FAM193B
FZR1
GANAB
GARS
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A3
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IKBKAP
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K1
MAP3K2
MAP3K4
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SERPINB4
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
Entrez ID
7024
5599
HPRD ID
01790
03100
Ensembl ID
ENSG00000135457
ENSG00000107643
Uniprot IDs
Q12800
A1L4K2
P45983
Q308M2
PDB IDs
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4L7F
Enriched GO Terms of Interacting Partners
?
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
RNA Metabolic Process
Transcription, DNA-templated
Nucleobase-containing Compound Metabolic Process
RNA Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Cellular Response To DNA Damage Stimulus
Cellular Metabolic Process
Cellular Response To Stress
Chromatin Modification
Cellular Protein Metabolic Process
Histone Modification
Chromatin Organization
Negative Regulation Of Gene Expression
Cell Cycle
Negative Regulation Of Cellular Metabolic Process
Protein Metabolic Process
Histone Deacetylation
Regulation Of Gene Expression
Chromosome Organization
Regulation Of Metabolic Process
Protein Deacetylation
TRIF-dependent Toll-like Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Regulation Of Innate Immune Response
Activation Of Innate Immune Response
Metabolic Process
Negative Regulation Of Transcription, DNA-templated
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Stimulus
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of Biosynthetic Process
Regulation Of Organelle Organization
Negative Regulation Of Gene Expression, Epigenetic
Cellular Protein Modification Process
Negative Regulation Of RNA Biosynthetic Process
Peptidyl-amino Acid Modification
Toll-like Receptor 4 Signaling Pathway
Anatomical Structure Development
Anatomical Structure Morphogenesis
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Protein Metabolic Process
Regulation Of Metabolic Process
Regulation Of Phosphorylation
Response To Stress
Regulation Of Phosphorus Metabolic Process
Intracellular Signal Transduction
Regulation Of Protein Phosphorylation
Positive Regulation Of Metabolic Process
Regulation Of Kinase Activity
Response To Organic Substance
Cellular Response To Organic Substance
Cellular Response To Growth Factor Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Protein Kinase Activity
Response To Growth Factor
Apoptotic Process
Cellular Response To Stimulus
Programmed Cell Death
Cellular Response To Stress
Signaling
Signal Transduction
Cell Death
Death
MAPK Cascade
Cell Communication
Positive Regulation Of Cellular Biosynthetic Process
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Signal Transduction By Phosphorylation
Negative Regulation Of Cellular Metabolic Process
Defense Response
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Stress-activated MAPK Cascade
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Signaling
Positive Regulation Of Gene Expression
Regulation Of MAP Kinase Activity
Innate Immune Response
Positive Regulation Of Signal Transduction
Response To Stimulus
Regulation Of Cellular Process
Response To Abiotic Stimulus
Immune System Process
Regulation Of Nitrogen Compound Metabolic Process
Developmental Process
Tagcloud
?
abeta1
autophagic
autophagosomes
autophagy
bcl2
beclin
becn1
buildup
digested
elevation
favor
favoring
flux
hamper
incompletely
jnk1
jnk2
lc3
lysosomal
mapk9
modifying
monomers
neuroblastoma
oligomers
phosphorylating
profound
sk
turn
vacuoles
Tagcloud (Difference)
?
abeta1
autophagic
autophagosomes
autophagy
bcl2
beclin
becn1
buildup
digested
elevation
favor
favoring
flux
hamper
incompletely
jnk1
jnk2
lc3
lysosomal
mapk9
modifying
monomers
neuroblastoma
oligomers
phosphorylating
profound
sk
turn
vacuoles
Tagcloud (Intersection)
?