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UBE2I and TRAF3
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
UBE2I
TRAF3
Description
ubiquitin conjugating enzyme E2 I
TNF receptor associated factor 3
Image
GO Annotations
Cellular Component
Synaptonemal Complex
Nucleus
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Cytoplasm
Cytosol
Nuclear Body
PML Body
Perinuclear Region Of Cytoplasm
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Presynaptic Cytosol
Postsynaptic Cytosol
SUMO Ligase Complex
Transferase Complex
Ubiquitin Ligase Complex
Cytoplasm
Mitochondrion
Endosome
Cytosol
Cytoplasmic Side Of Plasma Membrane
Endosome Membrane
Membrane
CD40 Receptor Complex
Serine/threonine Protein Kinase Complex
Molecular Function
Nucleotide Binding
Transcription Coregulator Binding
RNA Binding
Protein Binding
ATP Binding
Transcription Factor Binding
Transferase Activity
SUMO Transferase Activity
Enzyme Binding
HLH Domain Binding
Small Protein Activating Enzyme Binding
SUMO Conjugating Enzyme Activity
RING-like Zinc Finger Domain Binding
Ubiquitin-protein Transferase Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Zinc Ion Binding
Transferase Activity
Protein Kinase Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
Thioesterase Binding
Signaling Adaptor Activity
Identical Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Chromosome Segregation
Mitotic Nuclear Membrane Reassembly
Protein Sumoylation
Positive Regulation Of Cell Migration
Protein Modification Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Negative Regulation Of DNA-templated Transcription
Modulation Of Chemical Synaptic Transmission
Nuclear Export
Cell Division
Regulation Of Cytokine Production
Toll-like Receptor Signaling Pathway
Immune System Process
Apoptotic Process
Signal Transduction
Cell Surface Receptor Signaling Pathway
Toll Signaling Pathway
MRNA Transcription
Regulation Of Proteolysis
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Type I Interferon Production
Positive Regulation Of Type I Interferon Production
Regulation Of Interferon-beta Production
Tumor Necrosis Factor-mediated Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Canonical NF-kappaB Signal Transduction
Innate Immune Response
Regulation Of Defense Response To Virus
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Antiviral Innate Immune Response
Pathways
Meiotic synapsis
Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SUMOylation of nuclear envelope proteins
PKR-mediated signaling
Regulation of endogenous retroelements by KRAB-ZFP proteins
Transcriptional and post-translational regulation of MITF-M expression and activity
TRAF3 deficiency - HSE
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ovarian tumor domain proteases
TICAM1-dependent activation of IRF3/IRF7
TRAF3-dependent IRF activation pathway
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7
Regulation of TBK1, IKKε-mediated activation of IRF3, IRF7 upon TLR3 ligation
Drugs
Diseases
GWAS
Appendicular lean mass (
33097823
)
Idiopathic dilated cardiomyopathy (
29495422
)
Monocyte percentage of white cells (
32888494
)
Pulse pressure (
30224653
30578418
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
White blood cell count (
32888494
)
Adult body size (
32376654
)
Age at first birth (
34211149
)
Age at first sexual intercourse (
34211149
)
Albumin-globulin ratio (
29403010
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Apolipoprotein A1 levels (
32203549
)
Asthma (
32296059
)
Asthma (childhood onset) (
30929738
)
Body mass index (
29273807
25673413
)
Body size at age 10 (
32376654
)
Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) (
19023125
)
Composite immunoglobulin trait (IgA x IgG/IgM) (
28628107
)
Eczema (
31361310
)
Gallstone disease (
30692554
)
Gastroesophageal reflux disease, peptic ulcer disease and/or corresponding medications and treatment (
33608531
)
HDL cholesterol levels (
32203549
)
Immunoglobulin measurement (zinc sulfate turbidity test) (
29403010
)
Lymphocyte count (
27863252
32888494
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Major depressive disorder (MTAG) (
33479212
)
Monocyte count (
32888494
)
Multiple sclerosis (
24076602
31604244
)
Neutrophil percentage of white cells (
32888494
)
Non-albumin protein levels (
29403010
)
Red blood cell count (
32888494
)
Serum total protein levels (
29403010
)
Systemic lupus erythematosus (
33536424
28714469
)
Type 2 diabetes (
32499647
)
Interacting Genes
486 interacting genes:
-
ACTB
ADAR
ADARB1
ADD3
AGR2
AGTRAP
AKAP17A
ANAPC4
ANXA1
APEX1
APP
AR
ARHGDIA
ARK2N
ARL13B
ARL6IP1
ARNT
ARRB2
ATF2
ATF3
ATF7IP
ATXN1
AURKA
AURKB
BANP
BCAM
BCL11A
BCL2L1
BEND5
BHLHE40
BIRC3
BIRC7
BLM
BLMH
BMAL1
BMI1
BTBD3
CALU
CAMK2D
CAMK2G
CAMSAP2
CARD9
CARM1
CASP2
CASP8AP2
CBLC
CBS
CBX4
CCDC6
CD2AP
CDC37
CDCA8
CDH4
CDR2L
CEBPA
CEBPD
CEBPE
CENPX
CFL2
CFTR
CHD3
CHD4
CHFR
CHMP1A
CHMP4B
CHUK
CLDN2
CLK2
COG1
CORO2A
CREB1
CREBBP
CREBL2
CREM
CSGALNACT2
CSK
CSNK2B
CTBP2
CTNNA1
CYP4F2
DACH1
DAXX
DCTD
DDX21
DDX24
DDX39A
DDX39B
DDX5
DES
DHX9
DMC1
DNM1
DNMT3A
DNMT3B
DPPA2
DPYSL2
DRG1
DTX3L
DZIP3
EDARADD
EDF1
EGR2
EIF2AK2
EIF2B1
EIF5A
ELK1
EP300
ERCC6
ESR1
ETS1
ETV1
ETV6
EXO1
EXOSC9
FADD
FAF1
FAM118A
FANCM
FAS
FATE1
FHIT
FHL3
FLI1
FMR1
FOS
FOXL2
FOXM1
GCM1
GIPC2
GLUL
GMCL1
GMCL2
GMEB1
GMEB2
GOLGA1
GOLGA2
GOLGB1
GRIP1
GTF2I
H4C16
HABP4
HDAC1
HDAC4
HDAC5
HDAC7
HGS
HIC1
HIF1A
HIPK1
HIPK2
HIPK3
HIRA
HMBOX1
HMGB1
HMGN2
HMGXB4
HNF4A
HNRNPC
HNRNPCL1
HNRNPD
HNRNPK
HNRNPLL
HNRNPM
HNRNPU
HSF1
HSF2
HSF2BP
IKBKG
IKZF1
IKZF3
IKZF5
IMPDH1
IPO13
IQGAP1
JUN
JUNB
KAT2A
KAT6B
KCNA5
KCNK1
KCTD1
KDM1A
KHSRP
KLF3
KLF5
KLHL12
KLHL2
KMT5A
KRT19
KRTAP5-2
KRTAP5-4
KRTAP5-9
KTN1
LATS1
LCE1D
LCE1F
LCE2C
LCE3B
LCE5A
LMNA
LMNB1
LMO2
LNX2
LONRF1
LRSAM1
MALL
MAP2K1
MAP3K1
MAP3K5
MAPK1IP1L
MARCHF5
MAT2A
MATR3
MBD4
MDM2
MECOM
MED7
MEF2C
MGRN1
MIPOL1
MITF
MKRN3
MLX
MORC3
MRTFA
MTA1
MYB
MYBBP1A
MYH9
NACC1
NAF1
NAT10
NCOR2
NFE2
NFKBIA
NHP2
NIN
NMI
NOL6
NONO
NOP2
NOP56
NOP58
NOX5
NR1D2
NR1H2
NR1H3
NR1I2
NR3C1
NR3C2
NR5A1
NR5A2
NRIP1
NSD3
NUDCD3
NVL
PAICS
PARK7
PARP1
PAX5
PCNA
PDLIM7
PDPK1
PDZK1
PELI1
PEX10
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PIM1
PLAAT4
PLAGL1
PLK1
PML
POLR1H
POU1F1
POU2F1
PPARA
PPARG
PPARGC1A
PPCDC
PPM1J
PRKAA2
PRKDC
PROP1
PRPF40A
PRPF8
PRPSAP1
PSMC3
PSMC6
PSME3
PTEN
PUF60
RABAC1
RAD18
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RB1
RBBP5
RBBP6
RBBP8
RBM14
RBM25
RC3H2
RCBTB2
RFPL3
RHOB
RHOXF2
RIPK2
RNF10
RNF111
RNF115
RNF128
RNF133
RNF144B
RNF151
RNF185
RNF4
RNF40
ROCK2
RORB
RPL11
RPL7
RPL8
RPRD1B
RPS3A
RPS6KA6
RUSF1
RWDD3
RXRA
SAE1
SALL1
SART1
SATB1
SCNN1A
SEMA6A
SEPTIN1
SETBP1
SETDB1
SETX
SFPQ
SH3KBP1
SIAH1
SIAH2
SIRT1
SKIL
SLC2A1
SLC2A4
SLX4
SMAD4
SNAI2
SND1
SNIP1
SNRNP200
SOCS6
SOX10
SOX4
SOX5
SOX9
SP100
SP3
SPECC1L
SPOP
SREBF1
SREBF2
SRF
SRSF4
SSRP1
STAT1
STIP1
STMN2
STX1A
STX1B
STX2
SUMO1
SUMO1P1
SUMO2
SUMO3
SUPT7L
SUZ12
SYMPK
TAB2
TAF1
TAF10
TAF12
TAF5
TBL1X
TBL1XR1
TBP
TCERG1
TCF3
TCF4
TDG
TDP2
TERF2
TFAP2A
TFAP2B
TFAP2C
TFCP2
TFG
THAP1
THRA
THRB
TIGD3
TLK2
TNFRSF1A
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP63
TP73
TRAF2
TRAF3
TRAF4
TRAF6
TRIM21
TRIM23
TRIM24
TRIM27
TRIM28
TRIM29
TRIM38
TRIM41
TRIM54
TRIM63
TRIM72
TRIP13
TRPS1
TSHZ2
TSN
TSNAX
TTN
TXLNB
UBA2
UBE2K
UBQLN1
UBQLN2
UBXN1
UCHL1
UNC119
USP25
USP36
VENTX
VEZF1
VHL
WNK1
WT1
WWP2
XBP1
XIAP
XRCC1
XRCC5
YY1
ZBED1
ZBTB1
ZBTB16
ZBTB2
ZBTB26
ZBTB7A
ZBTB8A
ZBTB9
ZC3H10
ZCCHC12
ZCCHC7
ZEB2
ZG16
ZIC1
ZMYM2
ZNF106
ZNF24
ZNF408
ZNF446
ZNF451
ZNF618
ZNF646
ZNF837
ZNRD2
86 interacting genes:
ABCC1
ALPL
APOBEC3C
ASCC1
AZI2
BEX3
BIVM
C10orf62
CASP3
CCDC13
CCDC184
CD27
CD40
CDC37
CELF2
DAXX
EDA2R
EDAR
EWSR1
FAS
GMEB2
GRIN1
GRIN2D
HEMGN
HNRNPC
IFT25
IL15
IP6K3
IRF1
LNX1
LTBR
MAP2K1
MAP3K14
MAP3K7
MAVS
MFF
NEDD4L
NTAQ1
NUP62
OTUD5
PDLIM7
PDZD4
PIAS2
POM121
PSMB8
PTPN6
RAD23A
RIPK1
RIPPLY1
RNF216
RNF4
RRAS2
SAR1A
SHANK3
SRC
STK38
TANK
TBK1
TDP2
TICAM1
TNFRSF11A
TNFRSF12A
TNFRSF13C
TNFRSF14
TNFRSF17
TNFRSF18
TNFRSF19
TNFRSF1A
TNFRSF1B
TNFRSF4
TNFRSF8
TNFRSF9
TRADD
TRAF2
TRAF3IP1
TRAF3IP2
TRAF3IP3
TRAF5
TRIM24
TRIM37
UBE2I
USP7
ZBP1
ZBTB49
ZMYND11
ZSCAN4
Entrez ID
7329
7187
HPRD ID
09045
03539
Ensembl ID
ENSG00000103275
ENSG00000131323
Uniprot IDs
A8K503
P63279
Q7KZS0
A6NHG8
Q13114
PDB IDs
1A3S
1KPS
1Z5S
2GRN
2GRO
2GRP
2GRQ
2GRR
2O25
2PE6
2PX9
2XWU
3A4S
3UIN
3UIO
3UIP
4W5V
4Y1L
5D2M
5F6D
5F6E
5F6U
5F6V
5F6W
5F6X
5F6Y
5FQ2
6SYF
8ODR
9B62
1FLK
1FLL
1KZZ
1L0A
1RF3
1ZMS
2ECY
2GKW
8T5P
Enriched GO Terms of Interacting Partners
?
Nucleus
Nucleoplasm
Identical Protein Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of Primary Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
DNA Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Chromatin
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Macromolecule Metabolic Process
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
PML Body
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Nucleic Acid Metabolic Process
Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Chromatin Binding
Cellular Response To Stress
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-templated Transcription
Nucleobase-containing Compound Metabolic Process
Protein Modification By Small Protein Conjugation
Transcription Cis-regulatory Region Binding
Zinc Ion Binding
Tumor Necrosis Factor-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Tumor Necrosis Factor Receptor Activity
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Cell Surface Receptor Signaling Pathway
Apoptotic Process
Cell Death
Programmed Cell Death
Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Defense Response
Tumor Necrosis Factor Receptor Superfamily Complex
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Regulation Of Type I Interferon Production
Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Cytokine Production
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Intracellular Signal Transduction
Extrinsic Apoptotic Signaling Pathway
Apoptotic Signaling Pathway
Positive Regulation Of Defense Response
Signaling Receptor Activity
Positive Regulation Of Gene Expression
Death-inducing Signaling Complex
Defense Response To Virus
Regulation Of Cell Communication
Regulation Of Signaling
Ubiquitin Protein Ligase Binding
Regulation Of Macromolecule Metabolic Process
Regulation Of Mononuclear Cell Proliferation
Regulation Of JNK Cascade
Cellular Response To Mechanical Stimulus
Regulation Of Gene Expression
Intracellular Signal Transduction
Response To Stress
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
CD40 Signaling Pathway
Regulation Of Leukocyte Proliferation
Regulation Of Immune System Process
Regulation Of MAPK Cascade
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cytokine Production
Immune Response
Response To External Biotic Stimulus
Positive Regulation Of Type I Interferon Production
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Tagcloud (Intersection)
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