UBE2I and UCHL1

Number of citations of the paper that reports this interaction (PMID 12082530)
20

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBE2I	UCHL1
Gene Name		ubiquitin-conjugating enzyme E2I	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Image
Gene Ontology Annotations	Cellular Component	Synaptonemal Complex Fibrillar Center Nucleus Nucleoplasm Cytoplasm PML Body Dendrite Synapse Transferase Complex Sumoylated E2 Ligase Complex	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Axon Neuronal Cell Body Extracellular Vesicular Exosome
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Transcription Factor Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding HLH Domain Binding BHLH Transcription Factor Binding Poly(A) RNA Binding Ubiquitin Protein Ligase Activity SUMO Conjugating Enzyme Activity RING-like Zinc Finger Domain Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Mitotic Nuclear Division Regulation Of Receptor Activity Viral Process Protein Ubiquitination Protein Sumoylation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Division Positive Regulation Of SUMO Transferase Activity	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Proliferation Protein Deubiquitination Sensory Perception Of Pain Axon Transport Of Mitochondrion Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Muscle Fiber Development Neuromuscular Process
Pathways		Post-translational protein modification SUMOylation Meiotic synapsis Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs
Diseases
GWAS			Cognitive performance ( 19734545)
Protein-Protein Interactions		258 interactors: ADAR ANXA1 APEX1 AR ARNT ARNTL ATF2 ATF7IP ATXN1 BCAM BEND5 BIRC3 BIRC7 BLM BLMH BMI1 C18orf25 CARM1 CASP2 CASP8AP2 CBLC CBS CBX4 CDC37 CDCA8 CEBPD CEBPE CFTR CHD3 CHFR CHMP1A CHMP4B CHUK CLDN2 CLK2 CORO2A CREB1 CREBBP CREM CSNK2B CTBP2 DACH1 DAXX DES DHX9 DNM1 DNMT3A DNMT3B DRG1 DTX3L DZIP3 EDARADD EDF1 EGR2 ELK1 EP300 ESR1 ETS1 ETV6 EXOSC9 FAS FHIT FHL3 FLI1 FMR1 FOS FOXM1 GCM1 GLUL GMCL1P1 GMEB1 GMEB2 GOLGA2 GOLGB1 GRIP1 HABP4 HDAC1 HDAC4 HDAC5 HDAC7 HGS HIC1 HIPK1 HIPK2 HIPK3 HIST1H4A HIST4H4 HMGN2 HNF4A HNRNPC HNRNPD HNRNPK HNRNPLL HSF1 HSF2 HSF2BP IKZF1 IKZF3 IPO13 JUN KCNK1 KCTD1 KLHL12 KRT19 LMNA LMO2 LNX2 MAP3K1 MAPK1IP1L MARCH5 MDM2 MED7 MGRN1 MITF MKL1 MKRN3 MTA1 MYB NCOR2 NIN NR1D2 NR1H2 NR3C1 NR3C2 NR5A2 NUDCD3 PARK7 PARP1 PDLIM7 PDZK1 PELI1 PEX10 PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PLAGL1 PML PPARA PPARGC1A PPM1J PRKAA2 PRPF40A PSMC3 PTEN PUF60 RAD18 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBBP5 RBBP6 RC3H2 RCBTB2 RFPL3 RIPK2 RNF10 RNF111 RNF115 RNF128 RNF133 RNF144B RNF185 RNF4 RNF40 RORB RPS6KA6 SAE1 SALL1 SATB1 SCNN1A SETBP1 SETD8 SETDB1 SETX SIAH1 SIAH2 SIRT1 SKIL SLC2A1 SLC2A4 SMAD4 SNIP1 SOCS6 SOX10 SOX4 SP100 SP3 SPECC1L SREBF1 SREBF2 SRF STAT1 STRA13 SUMO1 SUMO1P1 SUMO2 SUMO3 SUZ12 TAB2 TAF1 TAF10 TAF12 TAF5 TBP TCF3 TCF7L2 TDG TDP2 TFAP2A TFAP2B TFAP2C TNFRSF1A TOP1 TOPORS TP53 TP63 TP73 TRAF3 TRAF4 TRAF6 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM38 TRIM41 TRIM54 TRIM63 TRIM72 TRPS1 UBA2 UBE2K UBXN1 UCHL1 UNC119 USP25 WHSC1L1 WT1 XBP1 XIAP ZBED1 ZBTB16 ZBTB26 ZBTB8A ZCCHC7 ZEB2 ZMYM2 ZNF106 ZNF451 ZNF646 ZNRD1	27 interactors: ADRA2A ADRA2B ADRA2C ADRB2 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PARK2 PLA2G2A RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28
Entrez ID		7329	7345
HPRD ID		09045	01877
Ensembl ID		ENSG00000103275	ENSG00000154277
Uniprot IDs		A8K503 B0QYN7 P63279	P09936
PDB IDs		1A3S 1KPS 1Z5Q 1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2O25 2PE6 2PX9 2XWU 3A4S 3UIN 3UIO 3UIP	2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Cellular Process Protein Ubiquitination Chromosome Organization Response To Organic Substance Metabolic Process Cellular Protein Modification Process Cellular Response To Stress Chromatin Organization Chromatin Modification Peptidyl-lysine Modification Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Cellular Response To Stimulus	Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Regulation Of Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Receptor Transactivation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epinephrine Secretion Regulation Of ERBB Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Norepinephrine Secretion Response To Stress Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Metabolic Process Cellular Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Protein Catabolic Process Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Smooth Muscle Contraction Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Activation Of Protein Kinase Activity Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Smooth Muscle Contraction Regulation Of Phosphorylation Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Protein Phosphorylation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Response To Abiotic Stimulus Negative Regulation Of Muscle Contraction Positive Regulation Of Transferase Activity Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of ERBB Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Protein Modification Process Response To Stimulus Positive Regulation Of Protein Metabolic Process
Tagcloud ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2n ube2q1 ube2z ubiquitin ubiquitination	1b5 allow antibodies antigen antigens conventionally cytoplasm discussed distributions dr embedded fixed hla immunoreactivity localization lymphoid mb1 mb2 membrane mt1 recognition recognize recognized restricted sections significance tal ultrastructural wax
Tagcloud (Difference) ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2n ube2q1 ube2z ubiquitin ubiquitination	1b5 allow antibodies antigen antigens conventionally cytoplasm discussed distributions dr embedded fixed hla immunoreactivity localization lymphoid mb1 mb2 membrane mt1 recognition recognize recognized restricted sections significance tal ultrastructural wax
Tagcloud (Intersection) ?