UBE2I and ADAR

Number of citations: 71 (PubMedID 16120648)
Data Source: BioGRID (enzymatic study)

		UBE2I	ADAR
Name		ubiquitin conjugating enzyme E2 I	adenosine deaminase RNA specific
Structure
GO Annotations	Cellular Component	Synaptonemal Complex Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Nuclear Body PML Body Perinuclear Region Of Cytoplasm Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol SUMO Ligase Complex Transferase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Membrane Nuclear Lumen Supraspliceosomal Complex
	Molecular Function	Nucleotide Binding Transcription Coregulator Binding RNA Binding Protein Binding ATP Binding Transcription Factor Binding Transferase Activity SUMO Transferase Activity Enzyme Binding HLH Domain Binding Small Protein Activating Enzyme Binding SUMO Conjugating Enzyme Activity RING-like Zinc Finger Domain Binding	DNA Binding RNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Adenosine Deaminase Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Mitotic Nuclear Membrane Reassembly Protein Sumoylation Positive Regulation Of Cell Migration Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Modulation Of Chemical Synaptic Transmission Nuclear Export Cell Division	Osteoblast Differentiation Hematopoietic Progenitor Cell Differentiation Immune System Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Adenosine To Inosine Editing RNA Processing MRNA Processing Protein Import Into Nucleus Protein Export From Nucleus Apoptotic Process Response To Virus Base Conversion Or Substitution Editing Erythrocyte Differentiation Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing MiRNA Processing Response To Interferon-alpha Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Definitive Hemopoiesis Negative Regulation Of Type I Interferon-mediated Signaling Pathway Hematopoietic Stem Cell Homeostasis RISC Complex Assembly Hepatocyte Apoptotic Process Cellular Response To Virus Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of Hepatocyte Apoptotic Process
Pathways		Meiotic synapsis Vitamin D (calciferol) metabolism SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation Maturation of nucleoprotein Maturation of nucleoprotein SARS-CoV-1 targets host intracellular signalling and regulatory pathways SUMOylation of nuclear envelope proteins PKR-mediated signaling Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional and post-translational regulation of MITF-M expression and activity	C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling PKR-mediated signaling
Diseases		None	Dyschromatosis symmetrica hereditaria
GWAS		Appendicular lean mass ( 33097823 ) Idiopathic dilated cardiomyopathy ( 29495422 ) Monocyte percentage of white cells ( 32888494 ) Pulse pressure ( 30224653 30578418 ) Refractive error ( 32231278 ) Systolic blood pressure ( 30578418 ) White blood cell count ( 32888494 )	Apolipoprotein A1 levels ( 32203549 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Interleukin-6 levels ( 33517400 ) Lung cancer ( 28604730 ) Prostate cancer ( 23535732 ) Squamous cell lung carcinoma ( 28604730 )
Interacting Genes		486 interacting genes: - ACTB ADAR ADARB1 ADD3 AGR2 AGTRAP AKAP17A ANAPC4 ANXA1 APEX1 APP AR ARHGDIA ARK2N ARL13B ARL6IP1 ARNT ARRB2 ATF2 ATF3 ATF7IP ATXN1 AURKA AURKB BANP BCAM BCL11A BCL2L1 BEND5 BHLHE40 BIRC3 BIRC7 BLM BLMH BMAL1 BMI1 BTBD3 CALU CAMK2D CAMK2G CAMSAP2 CARD9 CARM1 CASP2 CASP8AP2 CBLC CBS CBX4 CCDC6 CD2AP CDC37 CDCA8 CDH4 CDR2L CEBPA CEBPD CEBPE CENPX CFL2 CFTR CHD3 CHD4 CHFR CHMP1A CHMP4B CHUK CLDN2 CLK2 COG1 CORO2A CREB1 CREBBP CREBL2 CREM CSGALNACT2 CSK CSNK2B CTBP2 CTNNA1 CYP4F2 DACH1 DAXX DCTD DDX21 DDX24 DDX39A DDX39B DDX5 DES DHX9 DMC1 DNM1 DNMT3A DNMT3B DPPA2 DPYSL2 DRG1 DTX3L DZIP3 EDARADD EDF1 EGR2 EIF2AK2 EIF2B1 EIF5A ELK1 EP300 ERCC6 ESR1 ETS1 ETV1 ETV6 EXO1 EXOSC9 FADD FAF1 FAM118A FANCM FAS FATE1 FHIT FHL3 FLI1 FMR1 FOS FOXL2 FOXM1 GCM1 GIPC2 GLUL GMCL1 GMCL2 GMEB1 GMEB2 GOLGA1 GOLGA2 GOLGB1 GRIP1 GTF2I H4C16 HABP4 HDAC1 HDAC4 HDAC5 HDAC7 HGS HIC1 HIF1A HIPK1 HIPK2 HIPK3 HIRA HMBOX1 HMGB1 HMGN2 HMGXB4 HNF4A HNRNPC HNRNPCL1 HNRNPD HNRNPK HNRNPLL HNRNPM HNRNPU HSF1 HSF2 HSF2BP IKBKG IKZF1 IKZF3 IKZF5 IMPDH1 IPO13 IQGAP1 JUN JUNB KAT2A KAT6B KCNA5 KCNK1 KCTD1 KDM1A KHSRP KLF3 KLF5 KLHL12 KLHL2 KMT5A KRT19 KRTAP5-2 KRTAP5-4 KRTAP5-9 KTN1 LATS1 LCE1D LCE1F LCE2C LCE3B LCE5A LMNA LMNB1 LMO2 LNX2 LONRF1 LRSAM1 MALL MAP2K1 MAP3K1 MAP3K5 MAPK1IP1L MARCHF5 MAT2A MATR3 MBD4 MDM2 MECOM MED7 MEF2C MGRN1 MIPOL1 MITF MKRN3 MLX MORC3 MRTFA MTA1 MYB MYBBP1A MYH9 NACC1 NAF1 NAT10 NCOR2 NFE2 NFKBIA NHP2 NIN NMI NOL6 NONO NOP2 NOP56 NOP58 NOX5 NR1D2 NR1H2 NR1H3 NR1I2 NR3C1 NR3C2 NR5A1 NR5A2 NRIP1 NSD3 NUDCD3 NVL PAICS PARK7 PARP1 PAX5 PCNA PDLIM7 PDPK1 PDZK1 PELI1 PEX10 PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PIM1 PLAAT4 PLAGL1 PLK1 PML POLR1H POU1F1 POU2F1 PPARA PPARG PPARGC1A PPCDC PPM1J PRKAA2 PRKDC PROP1 PRPF40A PRPF8 PRPSAP1 PSMC3 PSMC6 PSME3 PTEN PUF60 RABAC1 RAD18 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBBP5 RBBP6 RBBP8 RBM14 RBM25 RC3H2 RCBTB2 RFPL3 RHOB RHOXF2 RIPK2 RNF10 RNF111 RNF115 RNF128 RNF133 RNF144B RNF151 RNF185 RNF4 RNF40 ROCK2 RORB RPL11 RPL7 RPL8 RPRD1B RPS3A RPS6KA6 RUSF1 RWDD3 RXRA SAE1 SALL1 SART1 SATB1 SCNN1A SEMA6A SEPTIN1 SETBP1 SETDB1 SETX SFPQ SH3KBP1 SIAH1 SIAH2 SIRT1 SKIL SLC2A1 SLC2A4 SLX4 SMAD4 SNAI2 SND1 SNIP1 SNRNP200 SOCS6 SOX10 SOX4 SOX5 SOX9 SP100 SP3 SPECC1L SPOP SREBF1 SREBF2 SRF SRSF4 SSRP1 STAT1 STIP1 STMN2 STX1A STX1B STX2 SUMO1 SUMO1P1 SUMO2 SUMO3 SUPT7L SUZ12 SYMPK TAB2 TAF1 TAF10 TAF12 TAF5 TBL1X TBL1XR1 TBP TCERG1 TCF3 TCF4 TDG TDP2 TERF2 TFAP2A TFAP2B TFAP2C TFCP2 TFG THAP1 THRA THRB TIGD3 TLK2 TNFRSF1A TOP1 TOP2A TOP2B TOPORS TP53 TP63 TP73 TRAF2 TRAF3 TRAF4 TRAF6 TRIM21 TRIM23 TRIM24 TRIM27 TRIM28 TRIM29 TRIM38 TRIM41 TRIM54 TRIM63 TRIM72 TRIP13 TRPS1 TSHZ2 TSN TSNAX TTN TXLNB UBA2 UBE2K UBQLN1 UBQLN2 UBXN1 UCHL1 UNC119 USP25 USP36 VENTX VEZF1 VHL WNK1 WT1 WWP2 XBP1 XIAP XRCC1 XRCC5 YY1 ZBED1 ZBTB1 ZBTB16 ZBTB2 ZBTB26 ZBTB7A ZBTB8A ZBTB9 ZC3H10 ZCCHC12 ZCCHC7 ZEB2 ZG16 ZIC1 ZMYM2 ZNF106 ZNF24 ZNF408 ZNF446 ZNF451 ZNF618 ZNF646 ZNF837 ZNRD2	10 interacting genes: CEBPA ERG HDLBP LINC00624 PTEN SMURF2 TGM2 UBE2I USP7 XPO1
Entrez ID		7329	103
HPRD ID		09045	07528
Ensembl ID		ENSG00000103275	ENSG00000160710
Uniprot IDs		A8K503 P63279 Q7KZS0	A0AAQ5BGH8 P55265
PDB IDs		1A3S 1KPS 1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2O25 2PE6 2PX9 2XWU 3A4S 3UIN 3UIO 3UIP 4W5V 4Y1L 5D2M 5F6D 5F6E 5F6U 5F6V 5F6W 5F6X 5F6Y 5FQ2 6SYF 8ODR 9B62	1QBJ 1QGP 1XMK 2ACJ 2GXB 2L54 2MDR 3F21 3F22 3F23 3IRQ 3IRR 5ZU1 5ZUO 5ZUP 7C0I 7ZJ1 7ZLQ 8GBC 8GBD
GO Terms Enriched among Interactors		Nucleus Nucleoplasm Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Macromolecule Metabolic Process Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding PML Body RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleic Acid Metabolic Process Sequence-specific DNA Binding DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding Cellular Response To Stress DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-templated Transcription Nucleobase-containing Compound Metabolic Process Protein Modification By Small Protein Conjugation Transcription Cis-regulatory Region Binding Zinc Ion Binding	Regulation Of Ubiquitin-dependent Protein Catabolic Process PML Body Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Synaptic Vesicle Clustering Membrane Assembly Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity SUMO Conjugating Enzyme Activity Regulation Of RNA Metabolic Process Nucleus Regulation Of Protein Catabolic Process Regulation Of Transcription By RNA Polymerase II Response To Vitamin B2 C/EBP Complex Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Protein Deamination Cellular Response To Triglyceride Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Cellular Response To Serotonin RING-like Zinc Finger Domain Binding Symbiont-mediated Disruption Of Host Cell PML Body Sterol Metabolic Process Nucleoplasm Cholesterol Metabolic Process Negative Regulation Of Metabolic Process White Fat Cell Proliferation Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells SUMO Ligase Complex HLH Domain Binding Response To Triglyceride