Wiki-Pi
About
Search
People
Updates
Search
BLM and BRIP1
Number of citations of the paper that reports this interaction (PubMedID
24895130
)
80
Data Source:
BioGRID
(pull down, pull down)
BLM
BRIP1
Description
BLM RecQ like helicase
BRCA1 interacting DNA helicase 1
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
PML Body
RecQ Family Helicase-topoisomerase III Complex
Protein-containing Complex
Nucleus
Nucleoplasm
Replication Fork
Cytoplasm
Nuclear Membrane
BRCA1-B Complex
Molecular Function
Nucleotide Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
P53 Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
Single-stranded DNA Binding
Helicase Activity
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Zinc Ion Binding
Four-way Junction Helicase Activity
Hydrolase Activity
Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides
Isomerase Activity
ATP Hydrolysis Activity
Identical Protein Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
Metal Ion Binding
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
DNA/DNA Annealing Activity
Nucleotide Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
RNA Helicase Activity
Helicase Activity
Protein Binding
ATP Binding
Hydrolase Activity
Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides
Isomerase Activity
ATP Hydrolysis Activity
5'-3' DNA Helicase Activity
Metal Ion Binding
Iron-sulfur Cluster Binding
4 Iron, 4 Sulfur Cluster Binding
Catalytic Activity, Acting On A Nucleic Acid
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
DNA Repair
DNA Recombination
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Response To X-ray
Replication Fork Processing
Telomere Maintenance Via Semi-conservative Replication
DNA Geometric Change
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of DNA Recombination
Protein Complex Oligomerization
Protein Homooligomerization
Negative Regulation Of Cell Division
Telomeric D-loop Disassembly
Resolution Of DNA Recombination Intermediates
Cellular Response To Ionizing Radiation
Cellular Response To Hydroxyurea
Cellular Response To Camptothecin
T-circle Formation
DNA Damage Checkpoint Signaling
Nucleobase-containing Compound Metabolic Process
DNA Repair
Nucleotide-excision Repair
Double-strand Break Repair
Regulation Of Transcription By RNA Polymerase II
DNA Damage Response
Homologous Chromosome Pairing At Meiosis
Spermatogenesis
Spermatogonial Cell Division
Spermatid Development
Male Gonad Development
Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination
Homologous Recombination
Interstrand Cross-link Repair
Chiasma Assembly
Seminiferous Tubule Development
Protein-DNA Covalent Cross-linking Repair
Double-strand Break Repair Involved In Meiotic Recombination
Pathways
Processive synthesis on the C-strand of the telomere
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Cytosolic iron-sulfur cluster assembly
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
Drugs
Diseases
Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
Fanconi anemia
GWAS
Coronary artery disease (
32469254
)
Daytime sleep phenotypes (
27126917
)
Cerebrospinal AB1-42 levels in normal cognition (
29274321
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Ovarian cancer (
21964575
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Interacting Genes
39 interacting genes:
ATR
ATRX
BRIP1
CASP3
CHAF1A
CHEK1
DNA2
EXO1
FANCD2
FBXW7
FEN1
JUN
MCRS1
MIB1
MLH1
MX1
NEK11
PSMD3
RAD51
RAD51D
RNF4
RNF8
RPA1
SMC1A
SPIDR
SUMO1
SUMO2
SUMO3
SYN1
TERF1
TERF2
TOP3A
TP53
TP53BP1
TRIM49
UBE2I
UPF2
USP37
WRN
10 interacting genes:
BLM
BRCA1
CREBBP
FANCD2
HDAC3
HNRNPC
HSD17B14
RPA1
SIRT1
TOPBP1
Entrez ID
641
83990
HPRD ID
05211
05797
Ensembl ID
ENSG00000197299
ENSG00000136492
Uniprot IDs
B7ZKN7
H0YNU5
P54132
A0A804HJU1
A0A804HL36
J3QKX0
Q9BX63
PDB IDs
2KV2
2MH9
2RRD
3WE2
3WE3
4CDG
4CGZ
4O3M
5LUP
5MK5
5U6K
7AUC
7AUD
7XUW
7XV0
1T15
1T29
3AL3
Enriched GO Terms of Interacting Partners
?
DNA Damage Response
DNA Repair
DNA Metabolic Process
Chromosome Organization
Cellular Response To Stress
Double-strand Break Repair
Macromolecule Metabolic Process
Chromosome, Telomeric Region
PML Body
Nucleic Acid Metabolic Process
Nucleoplasm
Response To Stress
Telomere Maintenance
Regulation Of DNA Metabolic Process
DNA Recombination
Telomere Organization
Regulation Of Cell Cycle
Chromosome
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle
Nucleus
Negative Regulation Of Cell Cycle Process
Positive Regulation Of DNA Metabolic Process
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
Replication Fork
Signal Transduction In Response To DNA Damage
Response To Radiation
Regulation Of DNA Replication
Interstrand Cross-link Repair
Nuclear Body
Chromosome Organization Involved In Meiotic Cell Cycle
DNA Damage Checkpoint Signaling
Organelle Organization
Nuclear Chromosome
T-circle Formation
Cellular Response To Ionizing Radiation
Negative Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Replicative Senescence
Regulation Of DNA Recombination
Recombinational Repair
Replication Fork Processing
DNA Replication
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of DNA Repair
Regulation Of Chromosome Organization
Condensed Nuclear Chromosome
Chromatin Binding
Recombinational Repair
Double-strand Break Repair
Double-strand Break Repair Via Homologous Recombination
DNA Repair
Response To Ionizing Radiation
Male Germ Cell Nucleus
Lateral Element
Mitotic DNA Damage Checkpoint Signaling
Mitotic DNA Integrity Checkpoint Signaling
P53 Binding
DNA Metabolic Process
Response To Radiation
DNA Recombination
DNA Damage Response
DNA Damage Checkpoint Signaling
Regulation Of Mitotic Cell Cycle
PML Body
Chromatin Organization
Negative Regulation Of Cell Cycle Process
Mitotic G2 DNA Damage Checkpoint Signaling
Condensed Chromosome
BRCA1-B Complex
Nucleic Acid Metabolic Process
Signal Transduction In Response To DNA Damage
Negative Regulation Of Cell Cycle
Condensed Nuclear Chromosome
Cellular Response To Radiation
Cellular Response To Stress
Mitotic G2/M Transition Checkpoint
Nucleoplasm
Damaged DNA Binding
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Cell Cycle Phase Transition
Cellular Response To Ionizing Radiation
Deacetylase Activity
Regulation Of DNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Random Inactivation Of X Chromosome
Peptidyl-lysine Acetylation
Protein Deacetylation
Protein Lysine Deacetylase Activity
DNA Repair Complex
Regulation Of Cellular Response To Heat
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin-protein Adaptor Activity
Histone Deacetylase Activity
Regulation Of Cell Cycle
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?