BLM and UPF2

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		BLM	UPF2
Gene Name		Bloom syndrome, RecQ helicase-like	UPF2 regulator of nonsense transcripts homolog (yeast)
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Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Lateral Element Male Germ Cell Nucleus Nucleus Replication Fork Nucleolus Cytoplasm Nuclear Matrix PML Body Pronucleus	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Bubble DNA Binding P53 Binding Single-stranded DNA Binding ATP-dependent DNA Helicase Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Helicase Activity Four-way Junction Helicase Activity ATPase Activity Annealing Helicase Activity ATP-dependent 3'-5' DNA Helicase Activity G-quadruplex DNA Binding	RNA Binding Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Strand Renaturation DNA Repair DNA Recombination Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To X-ray Replication Fork Processing DNA Duplex Unwinding Positive Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Recombination Negative Regulation Of Mitotic Recombination Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Replication Fork Protection Regulation Of Binding Protein Oligomerization Negative Regulation Of Cell Division Negative Regulation Of Thymocyte Apoptotic Process Cellular Response To Ionizing Radiation Cellular Response To Hydroxyurea Cellular Response To Camptothecin	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Gene Expression Organ Regeneration
Pathways		Meiotic recombination	Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		33 interactors: ATM ATR ATRX BRIP1 CASP3 CHAF1A CHEK1 FANCD2 FEN1 MCRS1 MIB1 MLH1 MX1 PSMD3 RAD51 RAD51D RNF8 RPA1 SMC1A SUMO1 SUMO2 SUMO3 SYN1 TERF1 TERF2 TOP3A TOPBP1 TP53 TP53BP1 TRIM49 UBE2I UPF2 WRN	75 interactors: ABCF2 AGPAT1 ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 GLTSCR2 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MYB NDUFA7 NOB1 NOMO1 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SKIV2L2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		641	26019
HPRD ID		05211	10405
Ensembl ID		ENSG00000197299	ENSG00000151461
Uniprot IDs		P54132	Q9HAU5
PDB IDs		2KV2 2RRD	1UW4 2WJV
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Metabolic Process DNA Repair Cellular Response To Stress Double-strand Break Repair Chromosome Organization DNA Recombination Cell Cycle Response To Stress Cell Cycle Process Organelle Organization Response To Radiation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cell Aging Telomere Maintenance Nitrogen Compound Metabolic Process Response To Ionizing Radiation Negative Regulation Of DNA Metabolic Process Meiotic Nuclear Division Meiotic Cell Cycle Cell Cycle Checkpoint Response To Abiotic Stimulus Replicative Senescence Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of DNA Replication Response To Gamma Radiation Cellular Response To Ionizing Radiation Regulation Of DNA Replication Response To UV Cellular Response To Radiation Mitotic Cell Cycle Protein Sumoylation Metabolic Process DNA Damage Checkpoint DNA Conformation Change Response To Stimulus Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cell Cycle Signal Transduction In Response To DNA Damage Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Process Aging Regulation Of Cell Cycle Process	Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process Gene Expression Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Histone MRNA Catabolic Process RRNA Processing Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Translational Initiation Viral Process Ribosome Biogenesis Biosynthetic Process Histone MRNA Metabolic Process Cellular Metabolic Process Translational Termination Protein Complex Disassembly Translational Elongation RNA Biosynthetic Process Ribonucleoprotein Complex Biogenesis Cellular Protein Complex Disassembly Viral Transcription NcRNA Metabolic Process SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Metabolic Process Establishment Of Protein Localization To Membrane Translation Protein Targeting To Membrane Nuclear MRNA Surveillance Protein Localization To Membrane
Tagcloud ?		bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol	achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi
Tagcloud (Difference) ?		bimodal binary biomolecular boundaries ca2 cca2 coexisting conductance cscl derive diagram distinguished electrolyte fluctuations gramicidin histogram histograms homogeneous incorporated inferred lifetime lifetimes mixtures mole monomodal pcx pg phosphatidylcholine phosphatidylglycerol	achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi
Tagcloud (Intersection) ?