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BLM and MCRS1
Number of citations of the paper that reports this interaction (PubMedID
15829507
)
0
Data Source:
BioGRID
(two hybrid)
BLM
MCRS1
Description
BLM RecQ like helicase
microspherule protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Chromosome
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
PML Body
RecQ Family Helicase-topoisomerase III Complex
Protein-containing Complex
Histone Acetyltransferase Complex
Chromosome, Centromeric Region
Kinetochore
Spindle Pole
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Lysosome
Centrosome
Cytoskeleton
Nuclear Body
Dendrite
Ino80 Complex
Centriolar Satellite
Perikaryon
NSL Complex
MLL1 Complex
Molecular Function
Nucleotide Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
P53 Binding
Nucleic Acid Binding
DNA Binding
DNA Helicase Activity
Single-stranded DNA Binding
Helicase Activity
Protein Binding
ATP Binding
ATP-dependent Activity, Acting On DNA
Zinc Ion Binding
Four-way Junction Helicase Activity
Hydrolase Activity
Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides
Isomerase Activity
ATP Hydrolysis Activity
Identical Protein Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
Metal Ion Binding
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
DNA/DNA Annealing Activity
G-quadruplex RNA Binding
Protein Binding
Poly(U) RNA Binding
Telomerase Inhibitor Activity
Poly(G) Binding
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Replication
DNA Repair
DNA Recombination
DNA Damage Response
Mitotic G2 DNA Damage Checkpoint Signaling
Response To X-ray
Replication Fork Processing
Telomere Maintenance Via Semi-conservative Replication
DNA Geometric Change
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of DNA Recombination
Protein Complex Oligomerization
Protein Homooligomerization
Negative Regulation Of Cell Division
Telomeric D-loop Disassembly
Resolution Of DNA Recombination Intermediates
Cellular Response To Ionizing Radiation
Cellular Response To Hydroxyurea
Cellular Response To Camptothecin
T-circle Formation
Telomere Maintenance
Regulation Of DNA Replication
DNA Repair
Regulation Of DNA Repair
DNA Recombination
Chromatin Organization
Chromatin Remodeling
DNA Damage Response
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Telomere Maintenance
Regulation Of Chromosome Organization
Protein Modification Process
Positive Regulation Of DNA Repair
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Regulation Of Cell Cycle
Regulation Of DNA Strand Elongation
Negative Regulation Of Telomere Maintenance Via Telomere Lengthening
Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Positive Regulation Of Protein Localization To Nucleolus
Pathways
Processive synthesis on the C-strand of the telomere
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to RAD51
Impaired BRCA2 binding to PALB2
HATs acetylate histones
UCH proteinases
DNA Damage Recognition in GG-NER
Formation of WDR5-containing histone-modifying complexes
Drugs
Diseases
Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Coronary artery disease (
32469254
)
Daytime sleep phenotypes (
27126917
)
Interacting Genes
39 interacting genes:
ATR
ATRX
BRIP1
CASP3
CHAF1A
CHEK1
DNA2
EXO1
FANCD2
FBXW7
FEN1
JUN
MCRS1
MIB1
MLH1
MX1
NEK11
PSMD3
RAD51
RAD51D
RNF4
RNF8
RPA1
SMC1A
SPIDR
SUMO1
SUMO2
SUMO3
SYN1
TERF1
TERF2
TOP3A
TP53
TP53BP1
TRIM49
UBE2I
UPF2
USP37
WRN
125 interacting genes:
AGGF1
ARK2N
AXIN2
BACH2
BEND3
BHLHA9
BHLHE40
BLM
BRD8
BRMS1
BRMS1L
C7orf57
C8orf34
CARD9
CATSPERT
CAVIN2
CBY2
CCDC13
CCDC136
CCDC85B
CCHCR1
CCNH
CDCA7L
CEP44
CEP70
CNTROB
COIL
CREB3L3
CRYAA
CYSRT1
CYTIP
DAXX
DRAP1
DSCR9
DVL2
EGR2
ERF
EVI5
FAM9A
FNDC8
FSD2
FXR1
FXR2
GAS7
GCC1
GEM
GIGYF1
GOLGA2
GPBP1
HMBOX1
HOOK2
IKZF1
IKZF3
IKZF4
JAKMIP1
KANK2
KAT7
KDM1A
KIAA1958
KRT35
KRTAP10-7
KRTAP2-3
KRTAP2-4
KXD1
LIG4
LSM6
LZTS1
MAGEA11
MAGEA6
MAPK9
MED4
MEOX1
MFAP1
MIER2
MIER3
NAA10
NAB2
NKAPD1
NOP2
OSBPL3
PBK
PBX2
PCM1
PHC2
PIBF1
PINX1
PKNOX2
PPP1R13B
PRMT5
PSTPIP1
PTEN
RABEP1
RALYL
RARA
RETREG3
RIPPLY3
SH2B2
SHANK3
SNAPC5
SP4
SRRM4
SSMEM1
SUV39H1
TADA2B
TBC1D1
TERT
TFAP4
TLE5
TNIP1
TNNI1
TP63
TRIM37
TRIM41
TSPYL2
UPF3B
USHBP1
WASHC3
WBP11
XIAP
ZBTB22
ZCCHC12
ZNF23
ZNF639
ZNF8
ZRANB1
Entrez ID
641
10445
HPRD ID
05211
11298
Ensembl ID
ENSG00000197299
ENSG00000187778
Uniprot IDs
B7ZKN7
H0YNU5
P54132
Q96EZ8
PDB IDs
2KV2
2MH9
2RRD
3WE2
3WE3
4CDG
4CGZ
4O3M
5LUP
5MK5
5U6K
7AUC
7AUD
7XUW
7XV0
Enriched GO Terms of Interacting Partners
?
DNA Damage Response
DNA Repair
DNA Metabolic Process
Chromosome Organization
Cellular Response To Stress
Double-strand Break Repair
Macromolecule Metabolic Process
Chromosome, Telomeric Region
PML Body
Nucleic Acid Metabolic Process
Nucleoplasm
Response To Stress
Telomere Maintenance
Regulation Of DNA Metabolic Process
DNA Recombination
Telomere Organization
Regulation Of Cell Cycle
Chromosome
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle
Nucleus
Negative Regulation Of Cell Cycle Process
Positive Regulation Of DNA Metabolic Process
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
Replication Fork
Signal Transduction In Response To DNA Damage
Response To Radiation
Regulation Of DNA Replication
Interstrand Cross-link Repair
Nuclear Body
Chromosome Organization Involved In Meiotic Cell Cycle
DNA Damage Checkpoint Signaling
Organelle Organization
Nuclear Chromosome
T-circle Formation
Cellular Response To Ionizing Radiation
Negative Regulation Of DNA Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Replicative Senescence
Regulation Of DNA Recombination
Recombinational Repair
Replication Fork Processing
DNA Replication
Negative Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of DNA Repair
Regulation Of Chromosome Organization
Condensed Nuclear Chromosome
Chromatin Binding
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Protein Binding
Negative Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
Identical Protein Binding
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleoplasm
Negative Regulation Of Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Histone Deacetylase Binding
Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
P53 Binding
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
DNA-binding Transcription Factor Activity
Positive Regulation Of Macromolecule Biosynthetic Process
Transcription Corepressor Activity
Protein-containing Complex
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Nucleolus
Chromatin Binding
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle
Protein Domain Specific Binding
Chromatin
Positive Regulation Of Biosynthetic Process
Regulation Of Neurogenesis
Positive Regulation Of Stem Cell Proliferation
Regulation Of Nervous System Development
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Regulation Of Cellular Senescence
Regulation Of Centromeric Sister Chromatid Cohesion
MRF Binding
Telomere Maintenance Via Telomerase
Sequence-specific DNA Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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