BLM and DNA2

Number of citations of the paper that reports this interaction (PubMedID 31153714)
64

Data Source:
BioGRID (pull down)

		BLM	DNA2
Description		BLM RecQ like helicase	DNA replication helicase/nuclease 2
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GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Lateral Element Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Cytoplasm Cytosol Nuclear Matrix PML Body RecQ Family Helicase-topoisomerase III Complex Protein-containing Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Gamma DNA Polymerase Complex Mitochondrial Nucleoid
	Molecular Function	Nucleotide Binding Four-way Junction DNA Binding Y-form DNA Binding Bubble DNA Binding P53 Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding Four-way Junction Helicase Activity Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity Identical Protein Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity Metal Ion Binding G-quadruplex DNA Binding Forked DNA-dependent Helicase Activity Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding DNA/DNA Annealing Activity	Nucleotide Binding DNA Binding DNA Helicase Activity RNA Binding Catalytic Activity Helicase Activity Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 5'-flap Endonuclease Activity Single-stranded DNA Helicase Activity Deoxyribonuclease (pyrimidine Dimer) Activity 5'-3' DNA Helicase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Replication DNA Repair DNA Recombination DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To X-ray Replication Fork Processing Telomere Maintenance Via Semi-conservative Replication DNA Geometric Change Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA Recombination Protein Complex Oligomerization Protein Homooligomerization Negative Regulation Of Cell Division Telomeric D-loop Disassembly Resolution Of DNA Recombination Intermediates Cellular Response To Ionizing Radiation Cellular Response To Hydroxyurea Cellular Response To Camptothecin T-circle Formation	DNA Replication Checkpoint Signaling Telomere Maintenance DNA Double-strand Break Processing DNA Replication Mitochondrial DNA Replication DNA Repair Base-excision Repair DNA Damage Response Telomere Maintenance Via Semi-conservative Replication DNA Geometric Change DNA Replication, Okazaki Fragment Processing DNA Replication, Removal Of RNA Primer Mitochondrial DNA Repair Positive Regulation Of DNA Replication Replication Fork Reversal T-circle Formation Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways		Processive synthesis on the C-strand of the telomere SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2	Removal of the Flap Intermediate from the C-strand HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation Removal of the Flap Intermediate G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases		Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Coronary artery disease ( 32469254) Daytime sleep phenotypes ( 27126917)	Hip circumference adjusted for BMI ( 34021172)
Interacting Genes		39 interacting genes: ATR ATRX BRIP1 CASP3 CHAF1A CHEK1 DNA2 EXO1 FANCD2 FBXW7 FEN1 JUN MCRS1 MIB1 MLH1 MX1 NEK11 PSMD3 RAD51 RAD51D RNF4 RNF8 RPA1 SMC1A SPIDR SUMO1 SUMO2 SUMO3 SYN1 TERF1 TERF2 TOP3A TP53 TP53BP1 TRIM49 UBE2I UPF2 USP37 WRN	3 interacting genes: BLM RBBP8 TRAF6
Entrez ID		641	1763
HPRD ID		05211	19123
Ensembl ID		ENSG00000197299	ENSG00000138346
Uniprot IDs		B7ZKN7 H0YNU5 P54132	P51530
PDB IDs		2KV2 2MH9 2RRD 3WE2 3WE3 4CDG 4CGZ 4O3M 5LUP 5MK5 5U6K 7AUC 7AUD 7XUW 7XV0	5EAY
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair DNA Metabolic Process Chromosome Organization Cellular Response To Stress Double-strand Break Repair Macromolecule Metabolic Process Chromosome, Telomeric Region PML Body Nucleic Acid Metabolic Process Nucleoplasm Response To Stress Telomere Maintenance Regulation Of DNA Metabolic Process DNA Recombination Telomere Organization Regulation Of Cell Cycle Chromosome Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Nucleus Negative Regulation Of Cell Cycle Process Positive Regulation Of DNA Metabolic Process Response To Ionizing Radiation Regulation Of Cell Cycle Process Replication Fork Signal Transduction In Response To DNA Damage Response To Radiation Regulation Of DNA Replication Interstrand Cross-link Repair Nuclear Body Chromosome Organization Involved In Meiotic Cell Cycle DNA Damage Checkpoint Signaling Organelle Organization Nuclear Chromosome T-circle Formation Cellular Response To Ionizing Radiation Negative Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Replicative Senescence Regulation Of DNA Recombination Recombinational Repair Replication Fork Processing DNA Replication Negative Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Regulation Of DNA Repair Regulation Of Chromosome Organization Condensed Nuclear Chromosome Chromatin Binding	DNA Double-strand Break Processing Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Negative Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Response Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Serine/threonine Kinase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Recombinational Repair Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Mitotic Cell Cycle Phase Transition Forked DNA-dependent Helicase Activity Regulation Of Protein Kinase Activity 8-hydroxy-2'-deoxyguanosine DNA Binding Double-strand Break Repair Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle DNA Recombination Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Kinase Activity RecQ Family Helicase-topoisomerase III Complex Telomeric D-loop Binding Y-form DNA Binding Negative Regulation Of Cell Cycle Process Cellular Response To Stress Cellular Response To Camptothecin Four-way Junction Helicase Activity BRCA1-C Complex Interleukin-17A-mediated Signaling Pathway Identical Protein Binding Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction Negative Regulation Of Cell Cycle Telomere Maintenance Via Semi-conservative Replication DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Cellular Response To Hydroxyurea DNA Geometric Change Resolution Of DNA Recombination Intermediates Regulation Of Protein Phosphorylation Telomeric Loop Disassembly Regulation Of Phosphorylation Telomeric D-loop Disassembly Bubble DNA Binding G-quadruplex DNA Binding Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Nucleic Acid Metabolic Process Single-stranded DNA Endodeoxyribonuclease Activity CD40 Signaling Pathway
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