APEX1 and HNRNPL

Number of citations of the paper that reports this interaction (PMID 11809897)
23

Data Source:
HPRD (in vivo, in vitro)

		APEX1	HNRNPL
Gene Name		APEX nuclease (multifunctional DNA repair enzyme) 1	heterogeneous nuclear ribonucleoprotein L
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Ribosome Nuclear Speck Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Membrane Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Damaged DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Endonuclease Activity Endodeoxyribonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Phosphodiesterase I Activity Uracil DNA N-glycosylase Activity Protein Binding Phosphoric Diester Hydrolase Activity Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity 3'-5' Exonuclease Activity Oxidoreductase Activity Site-specific Endodeoxyribonuclease Activity, Specific For Altered Base Chromatin DNA Binding Protein Complex Binding Poly(A) RNA Binding Metal Ion Binding NF-kappaB Binding	Nucleotide Binding RNA Binding Protein Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Aging Negative Regulation Of Smooth Muscle Cell Migration Telomere Maintenance Via Semi-conservative Replication Response To Drug Regulation Of MRNA Stability Cell Redox Homeostasis Positive Regulation Of DNA Repair Oxidation-reduction Process Cellular Response To Hydrogen Peroxide Cellular Response To CAMP Cellular Response To Peptide Hormone Stimulus DNA Demethylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription	MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing Gene Expression
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Homologous recombination repair of replication-independent double-strand breaks Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Double-Strand Break Repair Resolution of D-loop structures through Holliday junction intermediates Resolution of Abasic Sites (AP sites) Base Excision Repair Resolution of D-loop structures Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand Processive synthesis on the C-strand of the telomere S Phase Telomere C-strand (Lagging Strand) Synthesis Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER) Homologous Recombination Repair Displacement of DNA glycosylase by APE1	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ANP32A ANP32C APP CSNK2A1 DCTN1 EP300 FEN1 GZMA GZMK HDAC1 HIF1A HMGA1 HMGA2 HMGB2 HNRNPL HOXC13 HSPA1A MDM2 MUTYH NME1 NUDT3 NXF2 PCNA POLB POLR3D SET SRPK1 SRPK2 TCF21 TERF1 TERF2 TERF2IP TP53 TXN UBE2I XRCC1 XRCC5 XRCC6	16 interactors: APEX1 CSE1L CSNK2A1 FGFR3 HIST3H3 HMG20B HMGA1 HNRNPA2B1 HNRNPK IL7R ITCH NEDD4 PCBP2 PJA1 PTBP1 SUMO4
Entrez ID		328	3191
HPRD ID		00136	04360
Ensembl ID		ENSG00000100823	ENSG00000104824
Uniprot IDs		P27695 Q5TZP7	P14866 Q6NTA2
PDB IDs		1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM	3R27 3TO8
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Base-excision Repair Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Response To Stress Negative Regulation Of Cellular Metabolic Process Response To Stress Chromosome Organization Telomere Maintenance Cellular Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle DNA Repair Telomere Maintenance Via Telomere Lengthening Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Viral Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Metabolic Process DNA Replication DNA Conformation Change Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Death Negative Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cell Cycle Positive Regulation Of Cell Aging DNA Catabolic Process Chromatin Organization Cell Aging Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Regulation Of Binding Cellular Senescence Establishment Of Integrated Proviral Latency Biosynthetic Process Organelle Organization Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Cellular Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome RNA Splicing Negative Regulation Of RNA Splicing Regulation Of RNA Metabolic Process Negative Regulation Of Defense Response To Virus MRNA Processing Cellular Macromolecule Catabolic Process Protein K63-linked Ubiquitination Cellular Metabolic Process MRNA Metabolic Process Positive Regulation Of Protein Catabolic Process Viral Process Negative Regulation Of Type I Interferon Production RNA Processing RNA Metabolic Process Negative Regulation Of Mitotic Nuclear Division Protein Modification By Small Protein Conjugation Protein Catabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Response To Virus Negative Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Transmission Of Virus Development Involved In Symbiotic Interaction Catabolic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Gene Expression Base-excision Repair Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Immune Response Telomere Maintenance Negative Regulation Of Gene Expression Negative Regulation Of Cell Division Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Interleukin-7-mediated Signaling Pathway Oncogene-induced Cell Senescence Regulation Of Defense Response To Virus Negative Regulation Of Biosynthetic Process
Tagcloud ?		apurinic apyriminidinic asp carcinogenesis carrying contribution correlates drinking endometriosis endonuclease evaluating genotype genotypes genotyping gg glu instability joint lifestyles menarche polymorphic prediction q restriction rflp rs1130409 taiwan tg tt
Tagcloud (Difference) ?		apurinic apyriminidinic asp carcinogenesis carrying contribution correlates drinking endometriosis endonuclease evaluating genotype genotypes genotyping gg glu instability joint lifestyles menarche polymorphic prediction q restriction rflp rs1130409 taiwan tg tt
Tagcloud (Intersection) ?