APEX1 and XRCC6

Number of citations of the paper that reports this interaction (PMID 8621488)
19

Data Source:
HPRD (in vitro)

		APEX1	XRCC6
Gene Name		APEX nuclease (multifunctional DNA repair enzyme) 1	X-ray repair complementing defective repair in Chinese hamster cells 6
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Ribosome Nuclear Speck Perinuclear Region Of Cytoplasm	Nuclear Telomere Cap Complex Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol Membrane Ku70:Ku80 Complex Nonhomologous End Joining Complex
	Molecular Function	DNA Binding Damaged DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Endonuclease Activity Endodeoxyribonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Phosphodiesterase I Activity Uracil DNA N-glycosylase Activity Protein Binding Phosphoric Diester Hydrolase Activity Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity 3'-5' Exonuclease Activity Oxidoreductase Activity Site-specific Endodeoxyribonuclease Activity, Specific For Altered Base Chromatin DNA Binding Protein Complex Binding Poly(A) RNA Binding Metal Ion Binding NF-kappaB Binding	DNA Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Transcription Regulatory Region DNA Binding Poly(A) RNA Binding 5'-deoxyribose-5-phosphate Lyase Activity
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Aging Negative Regulation Of Smooth Muscle Cell Migration Telomere Maintenance Via Semi-conservative Replication Response To Drug Regulation Of MRNA Stability Cell Redox Homeostasis Positive Regulation Of DNA Repair Oxidation-reduction Process Cellular Response To Hydrogen Peroxide Cellular Response To CAMP Cellular Response To Peptide Hormone Stimulus DNA Demethylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription	Telomere Maintenance DNA Ligation DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Transcription, DNA-templated Brain Development Viral Process Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding V(D)J Recombination Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Neurogenesis Cellular Hyperosmotic Salinity Response Cellular Response To X-ray Establishment Of Integrated Proviral Latency
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Homologous recombination repair of replication-independent double-strand breaks Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Double-Strand Break Repair Resolution of D-loop structures through Holliday junction intermediates Resolution of Abasic Sites (AP sites) Base Excision Repair Resolution of D-loop structures Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand Processive synthesis on the C-strand of the telomere S Phase Telomere C-strand (Lagging Strand) Synthesis Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER) Homologous Recombination Repair Displacement of DNA glycosylase by APE1	Cytosolic sensors of pathogen-associated DNA HIV Infection Processing of DNA ends prior to end rejoining Integration of provirus Early Phase of HIV Life Cycle HIV Life Cycle Nonhomologous End-joining (NHEJ) STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN 2-LTR circle formation Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ANP32A ANP32C APP CSNK2A1 DCTN1 EP300 FEN1 GZMA GZMK HDAC1 HIF1A HMGA1 HMGA2 HMGB2 HNRNPL HOXC13 HSPA1A MDM2 MUTYH NME1 NUDT3 NXF2 PCNA POLB POLR3D SET SRPK1 SRPK2 TCF21 TERF1 TERF2 TERF2IP TP53 TXN UBE2I XRCC1 XRCC5 XRCC6	126 interactors: ABCD4 ABL1 ACD ADCY7 ANXA1 APEX1 AR ARAP1 ATP6V1E1 BARD1 BAZ1A BTG1 CAPN11 CBX5 CCNA1 CCT3 CD40 CDCA5 CDK2 CDKN1A CEBPA CENPU CHAF1A CHEK1 CLTC CLU CMTM6 COIL COPB1 CREBBP CSNK2A1 CTBP2 DLX2 DNTT EFNA1 EGFR EID1 ELF3 EP300 EPS8 FMNL1 GAL3ST4 GSE1 GZMA GZMB H2AFX HERPUD1 HMGA2 HN1L HOXB7 HOXC4 HOXD4 HSF1 HTT ILVBL KAT2A KAT2B KIAA0408 LIG3 MAP2K5 MAP4K2 MAPK8 MRE11A MSX2 NAA15 NCF4 NCL NCOA6 NHP2L1 NIT1 NOTCH1 PAEP PAFAH1B3 PARP1 PCNA PDK1 PDPK1 PDX1 PECAM1 PGAM1 PGR PIN1 PLGRKT PNRC2 POR POU2F1 POU2F2 PRKDC PRPF40A PTTG1 QRSL1 RASA1 RBBP4 RGS2 RNF146 RPLP1 RPS10 RRAS2 RUNX2 SDHC SEP15 SERPINA2 SERPINB9 SGOL1 SIRT3 SKIL SMAD3 SMAD7 SNTA1 SPARC TAC1 TADA3 TBCD TCF4 TERF2 TERF2IP TERT TP53 VAV1 VBP1 WBP4 WRN XRCC5 XRCC6BP1 YWHAZ ZNF512B
Entrez ID		328	2547
HPRD ID		00136	01071
Ensembl ID		ENSG00000100823	ENSG00000196419
Uniprot IDs		P27695 Q5TZP7	B1AHC8 B1AHC9 P12956
PDB IDs		1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM	1JEQ 1JEY 1JJR 3RZX
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Base-excision Repair Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Response To Stress Negative Regulation Of Cellular Metabolic Process Response To Stress Chromosome Organization Telomere Maintenance Cellular Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle DNA Repair Telomere Maintenance Via Telomere Lengthening Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Viral Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Metabolic Process DNA Replication DNA Conformation Change Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Death Negative Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cell Cycle Positive Regulation Of Cell Aging DNA Catabolic Process Chromatin Organization Cell Aging Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Regulation Of Binding Cellular Senescence Establishment Of Integrated Proviral Latency Biosynthetic Process Organelle Organization Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter	Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Cell Cycle Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process RNA Biosynthetic Process Macromolecule Biosynthetic Process Response To Stress Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Regulation Of Transcription, DNA-templated Chromosome Organization Regulation Of Cell Death Regulation Of Cellular Component Organization Regulation Of Nucleic Acid-templated Transcription Regulation Of Apoptotic Process Cell Cycle Process Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Response To Organic Substance Cellular Response To Stress Organelle Organization Positive Regulation Of Gene Expression Gene Expression DNA Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Telomere Maintenance Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cellular Process Mitotic Cell Cycle Embryo Development Negative Regulation Of Cell Death Negative Regulation Of Biosynthetic Process Cellular Response To DNA Damage Stimulus Biosynthetic Process Regulation Of Catalytic Activity Cellular Metabolic Process Cellular Response To Organic Substance
Tagcloud ?		apurinic apyriminidinic asp carcinogenesis carrying contribution correlates drinking endometriosis endonuclease evaluating genotype genotypes genotyping gg glu instability joint lifestyles menarche polymorphic prediction q restriction rflp rs1130409 taiwan tg tt	brca2 cellularity cg chance copyright cytopenia genesis genotype genotyped gg heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5
Tagcloud (Difference) ?		apurinic apyriminidinic asp carcinogenesis carrying contribution correlates drinking endometriosis endonuclease evaluating genotypes genotyping glu instability joint lifestyles menarche polymorphic prediction q restriction rflp rs1130409 taiwan tg tt	brca2 cellularity cg chance copyright cytopenia genesis genotyped heterozygote hypercellular john karyotype lig4 ltd normocellular polymorphism polymorphisms rad51 rs1801320 rs1805388 rs2267437 rs3835 rs4793191 rs9567623 sons wiley xrcc5
Tagcloud (Intersection) ?		genotype gg