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APEX1 and GZMK
Number of citations of the paper that reports this interaction (PubMedID
17008916
)
0
Data Source:
BioGRID
(enzymatic study)
APEX1
GZMK
Description
apurinic/apyrimidinic endodeoxyribonuclease 1
granzyme K
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Centrosome
Ribosome
Nuclear Speck
Perinuclear Region Of Cytoplasm
Extracellular Region
Extracellular Space
Symbiont Cell Surface
Molecular Function
DNA Binding
Damaged DNA Binding
Double-stranded Telomeric DNA Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Catalytic Activity
DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Nuclease Activity
Endonuclease Activity
DNA Endonuclease Activity
RNA-DNA Hybrid Ribonuclease Activity
Exonuclease Activity
Phosphodiesterase I Activity
Uracil DNA N-glycosylase Activity
Protein Binding
Phosphoric Diester Hydrolase Activity
3'-5'-DNA Exonuclease Activity
Double-stranded DNA Exodeoxyribonuclease Activity
Double-stranded DNA 3'-5' DNA Exonuclease Activity
3'-5' Exonuclease Activity
Oxidoreductase Activity
Hydrolase Activity
Chromatin DNA Binding
Deoxyribonuclease (pyrimidine Dimer) Activity
Metal Ion Binding
Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands
DNA-(abasic Site) Binding
Serine-type Endopeptidase Activity
Protein Binding
Glycosaminoglycan Binding
Peptidase Activity
Serine-type Peptidase Activity
Hydrolase Activity
Pattern Recognition Receptor Activity
Biological Process
Telomere Maintenance
DNA Repair
Base-excision Repair
Base-excision Repair, Gap-filling
DNA Catabolic Process
DNA Recombination
DNA Damage Response
Regulation Of Apoptotic Process
Regulation Of MRNA Stability
Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation
Cell Redox Homeostasis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance Via Base-excision Repair
Activation Of Membrane Attack Complex
Proteolysis
Complement Activation
Opsonization
Zymogen Activation
Killing Of Cells Of Another Organism
Positive Regulation Of Inflammatory Response
Protein Maturation
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Granzyme-mediated Programmed Cell Death Signaling Pathway
Complement Activation, GZMK Pathway
Pathways
Displacement of DNA glycosylase by APEX1
POLB-Dependent Long Patch Base Excision Repair
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
PCNA-Dependent Long Patch Base Excision Repair
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Resolution of Abasic Sites (AP sites)
Drugs
Lucanthone
Diseases
GWAS
Menopause (age at onset) (
26414677
)
Blood protein levels (
30072576
)
Interacting Genes
46 interacting genes:
ANP32A
ANP32CP
APP
CDC42
CEBPA
CSNK2A1
DCTN1
EP300
FBXO7
FEN1
GZMA
GZMK
HDAC1
HIF1A
HMGA1
HMGA2
HMGB2
HNRNPL
HOXC13
HSPA1A
LINC01554
MCL1
MDM2
MUTYH
NFE2L2
NME1
NUDT3
NXF2
PCNA
POLB
POLR3D
SET
SLC25A21-AS1
SRPK1
SRPK2
TCF21
TERF1
TERF2
TERF2IP
TP53
TXN
UBE2I
UBR3
XRCC1
XRCC5
XRCC6
13 interacting genes:
ACTG1
APEX1
GOLGA2
HMGB2
HNRNPK
LIG4
NPLOC4
PNKP
SET
TMBIM6
TUBB3
UFD1
VCP
Entrez ID
328
3003
HPRD ID
00136
02872
Ensembl ID
ENSG00000100823
ENSG00000113088
Uniprot IDs
P27695
Q5TZP7
P49863
PDB IDs
1BIX
1CQG
1CQH
1DE8
1DE9
1DEW
1E9N
1HD7
2ISI
2O3H
3U8U
4IEM
4LND
4QH9
4QHD
4QHE
5CFG
5DFF
5DFH
5DFI
5DFJ
5DG0
5WN0
5WN1
5WN2
5WN3
5WN4
5WN5
6BOQ
6BOR
6BOS
6BOT
6BOU
6BOV
6BOW
6MK3
6MKK
6MKM
6MKO
6P93
6P94
6W0Q
6W2P
6W3L
6W3N
6W3Q
6W3U
6W43
6W4I
6W4T
7LPG
7LPH
7LPI
7LPJ
7MCR
7MEV
7SUV
7SVB
7TC2
7TC3
7TR7
7U50
9DP1
9DP2
9DP3
9DP4
1MZA
1MZD
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Nucleoplasm
Nucleic Acid Metabolic Process
DNA Metabolic Process
5'-deoxyribose-5-phosphate Lyase Activity
Protein-containing Complex
DNA Damage Response
Damaged DNA Binding
Nuclear Telomere Cap Complex
Macromolecule Metabolic Process
Enzyme Binding
Negative Regulation Of DNA Metabolic Process
Cellular Response To Stress
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Telomere Maintenance
Negative Regulation Of Metabolic Process
DNA Binding
Base-excision Repair
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Chromatin
Negative Regulation Of RNA Metabolic Process
Response To Stress
Chromosome Organization
Transcription Cis-regulatory Region Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway
Telomere Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Double-stranded Telomeric DNA Binding
DNA Repair
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Signaling Pathway
Telomeric DNA Binding
Regulation Of Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of Biosynthetic Process
Response To Radiation
Chromosome, Telomeric Region
Regulation Of Primary Metabolic Process
Negative Regulation Of Telomere Maintenance
Regulation Of Metabolic Process
DNA Binding, Bending
Protein-DNA Complex
Double-strand Break Repair
DNA Biosynthetic Process
VCP-NPL4-UFD1 AAA ATPase Complex
K48-linked Polyubiquitin Modification-dependent Protein Binding
Retrograde Protein Transport, ER To Cytosol
UFD1-NPL4 Complex
Cellular Response To Topologically Incorrect Protein
Protein Exit From Endoplasmic Reticulum
Cellular Response To Stress
DNA Metabolic Process
Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of RIG-I Signaling Pathway
Damaged DNA Binding
Double-strand Break Repair
Response To Endoplasmic Reticulum Stress
Regulation Of Apoptotic Process
DNA Repair
Cellular Response To Misfolded Protein
Regulation Of Programmed Cell Death
Response To Misfolded Protein
ERAD Pathway
Base-excision Repair, Gap-filling
Nucleus
Ubiquitin Protein Ligase Binding
V(D)J Recombination
Regulation Of RIG-I Signaling Pathway
Regulation Of Type I Interferon Production
Regulation Of Macromolecule Metabolic Process
Organelle Organization
DNA Damage Response
Negative Regulation Of RNA Splicing
Negative Regulation Of Metabolic Process
Nucleic Acid Metabolic Process
Negative Regulation Of Apoptotic Process
Condensed Chromosome
Regulation Of Metabolic Process
Base-excision Repair
Negative Regulation Of Programmed Cell Death
Macromolecule Metabolic Process
Polyubiquitin Modification-dependent Protein Binding
Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Macromolecule Biosynthetic Process
Nucleoplasm
Somatic Cell DNA Recombination
Negative Regulation Of Type I Interferon Production
Negative Regulation Of Biosynthetic Process
Protein Domain Specific Binding
Basal Body Patch
Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands
Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Response To Stress
Telomere Maintenance Via Base-excision Repair
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Tagcloud (Intersection)
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