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APEX1 and HMGB2
Number of citations of the paper that reports this interaction (PubMedID
12524539
)
0
Data Source:
HPRD
(in vitro)
APEX1
HMGB2
Description
apurinic/apyrimidinic endodeoxyribonuclease 1
high mobility group box 2
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Centrosome
Ribosome
Nuclear Speck
Perinuclear Region Of Cytoplasm
Chromatin
Condensed Chromosome
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Cytoplasm
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Molecular Function
DNA Binding
Damaged DNA Binding
Double-stranded Telomeric DNA Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Catalytic Activity
DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Nuclease Activity
Endonuclease Activity
DNA Endonuclease Activity
RNA-DNA Hybrid Ribonuclease Activity
Exonuclease Activity
Phosphodiesterase I Activity
Uracil DNA N-glycosylase Activity
Protein Binding
Phosphoric Diester Hydrolase Activity
3'-5'-DNA Exonuclease Activity
Double-stranded DNA Exodeoxyribonuclease Activity
Double-stranded DNA 3'-5' DNA Exonuclease Activity
3'-5' Exonuclease Activity
Oxidoreductase Activity
Hydrolase Activity
Chromatin DNA Binding
Deoxyribonuclease (pyrimidine Dimer) Activity
Metal Ion Binding
Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands
DNA-(abasic Site) Binding
Four-way Junction DNA Binding
Transcription Cis-regulatory Region Binding
Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
Damaged DNA Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Coactivator Activity
RNA Binding
Protein Binding
Transcription Factor Binding
DNA Binding, Bending
Protein Domain Specific Binding
Chemoattractant Activity
Non-sequence-specific DNA Binding, Bending
RAGE Receptor Binding
Supercoiled DNA Binding
DNA-binding Transcription Factor Binding
Biological Process
Telomere Maintenance
DNA Repair
Base-excision Repair
Base-excision Repair, Gap-filling
DNA Catabolic Process
DNA Recombination
DNA Damage Response
Regulation Of Apoptotic Process
Regulation Of MRNA Stability
Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation
Cell Redox Homeostasis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance Via Base-excision Repair
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Endothelial Cell Proliferation
Immune System Process
Inflammatory Response To Antigenic Stimulus
DNA Topological Change
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Chromatin Organization
Nucleosome Assembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Chemotaxis
Inflammatory Response
Spermatogenesis
Spermatid Nucleus Differentiation
Male Gonad Development
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
DNA Geometric Change
Response To Lipopolysaccharide
Positive Regulation Of Interferon-beta Production
V(D)J Recombination
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Megakaryocyte Differentiation
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Response To Steroid Hormone
Regulation Of Neurogenesis
Defense Response To Gram-negative Bacterium
Defense Response To Gram-positive Bacterium
Positive Chemotaxis
Cell Chemotaxis
Cellular Response To Lipopolysaccharide
Regulation Of Stem Cell Proliferation
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Hemopoiesis
Pathways
Displacement of DNA glycosylase by APEX1
POLB-Dependent Long Patch Base Excision Repair
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
PCNA-Dependent Long Patch Base Excision Repair
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Resolution of Abasic Sites (AP sites)
Apoptosis induced DNA fragmentation
Drugs
Lucanthone
Diseases
GWAS
Menopause (age at onset) (
26414677
)
Interacting Genes
46 interacting genes:
ANP32A
ANP32CP
APP
CDC42
CEBPA
CSNK2A1
DCTN1
EP300
FBXO7
FEN1
GZMA
GZMK
HDAC1
HIF1A
HMGA1
HMGA2
HMGB2
HNRNPL
HOXC13
HSPA1A
LINC01554
MCL1
MDM2
MUTYH
NFE2L2
NME1
NUDT3
NXF2
PCNA
POLB
POLR3D
SET
SLC25A21-AS1
SRPK1
SRPK2
TCF21
TERF1
TERF2
TERF2IP
TP53
TXN
UBE2I
UBR3
XRCC1
XRCC5
XRCC6
54 interacting genes:
-
APEX1
APP
AR
ARCN1
BCCIP
C1QBP
CACTIN
CEBPA
CHAF1A
COMMD1
CRBN
CREBBP
CSNK1A1
EIF1
FBXO7
FLNA
GZMA
GZMK
H3-3A
HACD3
HDLBP
HMGA1
LZTS1
MIEN1
MYL6
NAP1L1
NCBP3
NEXN
NOP53
NR3C1
PCBP1
PGR
PKNOX1
POU2F1
POU2F2
POU3F1
POU5F1
PRKDC
RAG1
ROCK1
RPS28
SAMM50
SET
SNAPIN
TBC1D25
TP53
TSNAX
U2AF1
UHRF2
ZFR
ZNF428
ZNF622
ZNF668
Entrez ID
328
3148
HPRD ID
00136
01229
Ensembl ID
ENSG00000100823
ENSG00000164104
Uniprot IDs
P27695
Q5TZP7
P26583
PDB IDs
1BIX
1CQG
1CQH
1DE8
1DE9
1DEW
1E9N
1HD7
2ISI
2O3H
3U8U
4IEM
4LND
4QH9
4QHD
4QHE
5CFG
5DFF
5DFH
5DFI
5DFJ
5DG0
5WN0
5WN1
5WN2
5WN3
5WN4
5WN5
6BOQ
6BOR
6BOS
6BOT
6BOU
6BOV
6BOW
6MK3
6MKK
6MKM
6MKO
6P93
6P94
6W0Q
6W2P
6W3L
6W3N
6W3Q
6W3U
6W43
6W4I
6W4T
7LPG
7LPH
7LPI
7LPJ
7MCR
7MEV
7SUV
7SVB
7TC2
7TC3
7TR7
7U50
9DP1
9DP2
9DP3
9DP4
Enriched GO Terms of Interacting Partners
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Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleus
Nucleoplasm
Nucleic Acid Metabolic Process
DNA Metabolic Process
5'-deoxyribose-5-phosphate Lyase Activity
Protein-containing Complex
DNA Damage Response
Damaged DNA Binding
Nuclear Telomere Cap Complex
Macromolecule Metabolic Process
Enzyme Binding
Negative Regulation Of DNA Metabolic Process
Cellular Response To Stress
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Telomere Maintenance
Negative Regulation Of Metabolic Process
DNA Binding
Base-excision Repair
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Chromatin
Negative Regulation Of RNA Metabolic Process
Response To Stress
Chromosome Organization
Transcription Cis-regulatory Region Binding
Regulation Of Intrinsic Apoptotic Signaling Pathway
Telomere Organization
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Double-stranded Telomeric DNA Binding
DNA Repair
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Signaling Pathway
Telomeric DNA Binding
Regulation Of Cellular Response To Stress
Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of Biosynthetic Process
Response To Radiation
Chromosome, Telomeric Region
Regulation Of Primary Metabolic Process
Negative Regulation Of Telomere Maintenance
Regulation Of Metabolic Process
DNA Binding, Bending
Protein-DNA Complex
Double-strand Break Repair
DNA Biosynthetic Process
Nucleus
RNA Binding
Nucleic Acid Metabolic Process
Regulation Of MiRNA Transcription
DNA Metabolic Process
Regulation Of MiRNA Metabolic Process
DNA Binding
Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Chromatin
Sequence-specific DNA Binding
Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
DNA Repair
Transcription Coactivator Binding
Negative Regulation Of Biosynthetic Process
Positive Regulation Of MiRNA Transcription
Transcription Regulator Complex
Regulation Of Apoptotic Process
Chromatin Organization
Positive Regulation Of MiRNA Metabolic Process
Regulation Of Programmed Cell Death
Chromatin Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase I
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Metabolic Process
Estrogen Response Element Binding
Regulation Of Gene Expression
Nucleoplasm
Cytoplasm
Chromatin Remodeling
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Nuclear Speck
Negative Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Neuron Apoptotic Process
Regulation Of Protein Stability
Negative Regulation Of RNA Metabolic Process
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