APEX1 and UBR3

Number of citations of the paper that reports this interaction (PubMedID 21933813)
43

Data Source:
BioGRID (enzymatic study)

		APEX1	UBR3
Description		apurinic/apyrimidinic endodeoxyribonuclease 1	ubiquitin protein ligase E3 component n-recognin 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Ribosome Nuclear Speck Perinuclear Region Of Cytoplasm	Ubiquitin Ligase Complex Cytoplasm Membrane
	Molecular Function	DNA Binding Damaged DNA Binding Double-stranded Telomeric DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Phosphodiesterase I Activity Uracil DNA N-glycosylase Activity Protein Binding Phosphoric Diester Hydrolase Activity 3'-5'-DNA Exonuclease Activity Double-stranded DNA Exodeoxyribonuclease Activity Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Oxidoreductase Activity Hydrolase Activity Chromatin DNA Binding Deoxyribonuclease (pyrimidine Dimer) Activity Metal Ion Binding Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands DNA-(abasic Site) Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Telomere Maintenance DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Catabolic Process DNA Recombination DNA Damage Response Regulation Of Apoptotic Process Regulation Of MRNA Stability Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Cell Redox Homeostasis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Base-excision Repair	In Utero Embryonic Development Suckling Behavior Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Smell Embryo Development Ending In Birth Or Egg Hatching Protein Ubiquitination Olfactory Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways		Displacement of DNA glycosylase by APEX1 POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA-Dependent Long Patch Base Excision Repair Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs		Lucanthone
Diseases
GWAS		Menopause (age at onset) ( 26414677)	Longitudinal change in brain amyloid plaque burden ( 26268530) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Urate levels in obese individuals ( 25811787)
Interacting Genes		46 interacting genes: ANP32A ANP32CP APP CDC42 CEBPA CSNK2A1 DCTN1 EP300 FBXO7 FEN1 GZMA GZMK HDAC1 HIF1A HMGA1 HMGA2 HMGB2 HNRNPL HOXC13 HSPA1A LINC01554 MCL1 MDM2 MUTYH NFE2L2 NME1 NUDT3 NXF2 PCNA POLB POLR3D SET SLC25A21-AS1 SRPK1 SRPK2 TCF21 TERF1 TERF2 TERF2IP TP53 TXN UBE2I UBR3 XRCC1 XRCC5 XRCC6	7 interacting genes: APEX1 DZIP3 MAGEC2 UBE2A UBE2B UBE2D2 UBE2H
Entrez ID		328	130507
HPRD ID		00136	15887
Ensembl ID		ENSG00000100823	ENSG00000144357
Uniprot IDs		P27695 Q5TZP7	Q6ZT12
PDB IDs		1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM 4LND 4QH9 4QHD 4QHE 5CFG 5DFF 5DFH 5DFI 5DFJ 5DG0 5WN0 5WN1 5WN2 5WN3 5WN4 5WN5 6BOQ 6BOR 6BOS 6BOT 6BOU 6BOV 6BOW 6MK3 6MKK 6MKM 6MKO 6P93 6P94 6W0Q 6W2P 6W3L 6W3N 6W3Q 6W3U 6W43 6W4I 6W4T 7LPG 7LPH 7LPI 7LPJ 7MCR 7MEV 7SUV 7SVB 7TC2 7TC3 7TR7 7U50 9DP1 9DP2 9DP3 9DP4
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Nucleic Acid Metabolic Process DNA Metabolic Process 5'-deoxyribose-5-phosphate Lyase Activity Protein-containing Complex DNA Damage Response Damaged DNA Binding Nuclear Telomere Cap Complex Macromolecule Metabolic Process Enzyme Binding Negative Regulation Of DNA Metabolic Process Cellular Response To Stress Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Telomere Maintenance Negative Regulation Of Metabolic Process DNA Binding Base-excision Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Negative Regulation Of RNA Metabolic Process Response To Stress Chromosome Organization Transcription Cis-regulatory Region Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Telomere Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Double-stranded Telomeric DNA Binding DNA Repair Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Telomeric DNA Binding Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Biosynthetic Process Response To Radiation Chromosome, Telomeric Region Regulation Of Primary Metabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Metabolic Process DNA Binding, Bending Protein-DNA Complex Double-strand Break Repair DNA Biosynthetic Process	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Macromolecule Catabolic Process HULC Complex Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-like Protein Transferase Activity Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Postreplication Repair Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification Process Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Telomere Maintenance Via Base-excision Repair Transferase Activity Protein Autoubiquitination Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process DNA-(abasic Site) Binding Double-stranded DNA Exodeoxyribonuclease Activity Deoxyribonuclease (pyrimidine Dimer) Activity Macromolecule Metabolic Process Positive Regulation Of Reciprocal Meiotic Recombination Proteasomal Protein Catabolic Process Proteolysis DNA Repair Uracil DNA N-glycosylase Activity Phosphodiesterase I Activity ATP Binding Response To UV Double-stranded DNA 3'-5' DNA Exonuclease Activity Chiasma Assembly RNA-DNA Hybrid Ribonuclease Activity BBSome DNA Metabolic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Double-stranded Telomeric DNA Binding Telomere Localization DNA Damage Response 3'-5'-DNA Exonuclease Activity Nucleotide Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?