APEX1 and XRCC1

Number of citations of the paper that reports this interaction (PMID 11707423)
93

Data Source:
HPRD (in vivo, two hybrid)

		APEX1	XRCC1
Gene Name		APEX nuclease (multifunctional DNA repair enzyme) 1	X-ray repair complementing defective repair in Chinese hamster cells 1
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Ribosome Nuclear Speck Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Damaged DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Endonuclease Activity Endodeoxyribonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Phosphodiesterase I Activity Uracil DNA N-glycosylase Activity Protein Binding Phosphoric Diester Hydrolase Activity Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity 3'-5' Exonuclease Activity Oxidoreductase Activity Site-specific Endodeoxyribonuclease Activity, Specific For Altered Base Chromatin DNA Binding Protein Complex Binding Poly(A) RNA Binding Metal Ion Binding NF-kappaB Binding	Damaged DNA Binding Protein Binding Enzyme Binding
	Biological Process	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Aging Negative Regulation Of Smooth Muscle Cell Migration Telomere Maintenance Via Semi-conservative Replication Response To Drug Regulation Of MRNA Stability Cell Redox Homeostasis Positive Regulation Of DNA Repair Oxidation-reduction Process Cellular Response To Hydrogen Peroxide Cellular Response To CAMP Cellular Response To Peptide Hormone Stimulus DNA Demethylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleic Acid-templated Transcription	Single Strand Break Repair DNA Repair Base-excision Repair
Pathways		Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Telomere Maintenance Removal of DNA patch containing abasic residue Resolution of AP sites via the single-nucleotide replacement pathway Homologous recombination repair of replication-independent double-strand breaks Base-free sugar-phosphate removal via the single-nucleotide replacement pathway Double-Strand Break Repair Resolution of D-loop structures through Holliday junction intermediates Resolution of Abasic Sites (AP sites) Base Excision Repair Resolution of D-loop structures Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand Processive synthesis on the C-strand of the telomere S Phase Telomere C-strand (Lagging Strand) Synthesis Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER) Homologous Recombination Repair Displacement of DNA glycosylase by APE1	Base Excision Repair Resolution of AP sites via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs
Diseases
GWAS
Protein-Protein Interactions		38 interactors: ANP32A ANP32C APP CSNK2A1 DCTN1 EP300 FEN1 GZMA GZMK HDAC1 HIF1A HMGA1 HMGA2 HMGB2 HNRNPL HOXC13 HSPA1A MDM2 MUTYH NME1 NUDT3 NXF2 PCNA POLB POLR3D SET SRPK1 SRPK2 TCF21 TERF1 TERF2 TERF2IP TP53 TXN UBE2I XRCC1 XRCC5 XRCC6	16 interactors: APEX1 APLF APTX BRCA1 CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB RNF146 SUMO1
Entrez ID		328	7515
HPRD ID		00136	01909
Ensembl ID		ENSG00000100823	ENSG00000073050
Uniprot IDs		P27695 Q5TZP7	B2RCY5 P18887 Q59HH7
PDB IDs		1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Base-excision Repair Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Response To Stress Negative Regulation Of Cellular Metabolic Process Response To Stress Chromosome Organization Telomere Maintenance Cellular Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Gene Expression Negative Regulation Of Biosynthetic Process Mitotic Cell Cycle DNA Repair Telomere Maintenance Via Telomere Lengthening Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Cellular Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Viral Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Metabolic Process DNA Replication DNA Conformation Change Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Death Negative Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cell Cycle Positive Regulation Of Cell Aging DNA Catabolic Process Chromatin Organization Cell Aging Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Regulation Of Binding Cellular Senescence Establishment Of Integrated Proviral Latency Biosynthetic Process Organelle Organization Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter	DNA Repair Base-excision Repair Cellular Response To DNA Damage Stimulus DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair DNA Catabolic Process Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process Response To Stress DNA-dependent DNA Replication DNA Replication Nucleic Acid Phosphodiester Bond Hydrolysis Response To Stimulus Response To Oxidative Stress DNA Catabolic Process, Endonucleolytic Aromatic Compound Catabolic Process Polynucleotide 3' Dephosphorylation Cellular Macromolecule Catabolic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cellular Metabolic Process Positive Regulation Of DNA Metabolic Process Response To Inorganic Substance DNA Damage Response, Detection Of DNA Damage DNA Recombination Telomere Maintenance Cellular Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization DNA Ligation Regulation Of Nitrogen Compound Metabolic Process DNA Biosynthetic Process Nucleotide-excision Repair, DNA Gap Filling Catabolic Process Telomere Maintenance Via Semi-conservative Replication Postreplication Repair Single Strand Break Repair Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear DNA Replication Telomere Maintenance Via Recombination Protein ADP-ribosylation Cell Cycle Metabolic Process
Tagcloud ?		apurinic apyriminidinic asp carcinogenesis carrying contribution correlates drinking endometriosis endonuclease evaluating genotype genotypes genotyping gg glu instability joint lifestyles menarche polymorphic prediction q restriction rflp rs1130409 taiwan tg tt	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1
Tagcloud (Difference) ?		apurinic apyriminidinic asp carcinogenesis carrying contribution correlates drinking endometriosis endonuclease evaluating genotype genotypes genotyping gg glu instability joint lifestyles menarche polymorphic prediction q restriction rflp rs1130409 taiwan tg tt	apoc2 atp1a3 bckdha cgb cgm2 cyp2a d19s112 d19s116 d19s117 d19s118 d19s119 d19s19 d19s2 d19s37 d19s50 d19s51 d19s54 d19s55 d19s6 d19s62 d19s63 d19s7 d19s8 d19s9 manb pepd prkcg psg1 pw39 tnnt1
Tagcloud (Intersection) ?