APEX1 and FEN1

Number of citations of the paper that reports this interaction (PubMedID 11601988)
0

Data Source:
HPRD (in vitro, in vivo)

		APEX1	FEN1
Description		apurinic/apyrimidinic endodeoxyribonuclease 1	flap structure-specific endonuclease 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Ribosome Nuclear Speck Perinuclear Region Of Cytoplasm	Chromosome, Telomeric Region Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane Protein-containing Complex
	Molecular Function	DNA Binding Damaged DNA Binding Double-stranded Telomeric DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Catalytic Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Phosphodiesterase I Activity Uracil DNA N-glycosylase Activity Protein Binding Phosphoric Diester Hydrolase Activity 3'-5'-DNA Exonuclease Activity Double-stranded DNA Exodeoxyribonuclease Activity Double-stranded DNA 3'-5' DNA Exonuclease Activity 3'-5' Exonuclease Activity Oxidoreductase Activity Hydrolase Activity Chromatin DNA Binding Deoxyribonuclease (pyrimidine Dimer) Activity Metal Ion Binding Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands DNA-(abasic Site) Binding	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Catalytic Activity Nuclease Activity Endonuclease Activity DNA Endonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Exonuclease Activity Protein Binding Double-stranded DNA Exodeoxyribonuclease Activity 5'-3' Exonuclease Activity Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds 5'-flap Endonuclease Activity Manganese Ion Binding Metal Ion Binding Flap Endonuclease Activity
	Biological Process	Telomere Maintenance DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Catabolic Process DNA Recombination DNA Damage Response Regulation Of Apoptotic Process Regulation Of MRNA Stability Positive Regulation Of Gene Expression Via Chromosomal CpG Island Demethylation Cell Redox Homeostasis Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Telomere Maintenance Via Base-excision Repair	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Double-strand Break Repair DNA Recombination DNA Damage Response Memory UV Protection Telomere Maintenance Via Semi-conservative Replication DNA Replication, Removal Of RNA Primer Positive Regulation Of Sister Chromatid Cohesion
Pathways		Displacement of DNA glycosylase by APEX1 POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA-Dependent Long Patch Base Excision Repair Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Removal of the Flap Intermediate from the C-strand PCNA-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) Removal of the Flap Intermediate
Drugs		Lucanthone	Iron Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Menopause (age at onset) ( 26414677)	Asthma ( 31619474 31959851) Bipolar disorder ( 28115744 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 28067908) Daytime nap ( 33568662) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hemoglobin levels ( 32327693) Laryngeal squamous cell carcinoma ( 25194280) Male-pattern baldness ( 28196072) Metabolite levels ( 23378610 23823483) Oleic acid (18:1n-9) levels ( 23362303) Palmitoleic acid (16:1n-7) levels ( 23362303) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 22139419) QT interval ( 29874175) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278) Resting heart rate ( 27798624) Serum metabolite levels ( 23093944) Serum metabolite ratios in chronic kidney disease ( 29545352) Stearic acid (18:0) levels ( 23362303)
Interacting Genes		46 interacting genes: ANP32A ANP32CP APP CDC42 CEBPA CSNK2A1 DCTN1 EP300 FBXO7 FEN1 GZMA GZMK HDAC1 HIF1A HMGA1 HMGA2 HMGB2 HNRNPL HOXC13 HSPA1A LINC01554 MCL1 MDM2 MUTYH NFE2L2 NME1 NUDT3 NXF2 PCNA POLB POLR3D SET SLC25A21-AS1 SRPK1 SRPK2 TCF21 TERF1 TERF2 TERF2IP TP53 TXN UBE2I UBR3 XRCC1 XRCC5 XRCC6	20 interacting genes: APEX1 APP ARHGDIA BLM CCNA2 CDK1 CDK2 CEBPA EEF1G EP300 GSK3B HNRNPA1 HUS1 OGT PCNA RAD1 RAD9A TERF1 WDR4 WRN
Entrez ID		328	2237
HPRD ID		00136	02670
Ensembl ID		ENSG00000100823	ENSG00000168496
Uniprot IDs		P27695 Q5TZP7	P39748 Q6FHX6
PDB IDs		1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM 4LND 4QH9 4QHD 4QHE 5CFG 5DFF 5DFH 5DFI 5DFJ 5DG0 5WN0 5WN1 5WN2 5WN3 5WN4 5WN5 6BOQ 6BOR 6BOS 6BOT 6BOU 6BOV 6BOW 6MK3 6MKK 6MKM 6MKO 6P93 6P94 6W0Q 6W2P 6W3L 6W3N 6W3Q 6W3U 6W43 6W4I 6W4T 7LPG 7LPH 7LPI 7LPJ 7MCR 7MEV 7SUV 7SVB 7TC2 7TC3 7TR7 7U50 9DP1 9DP2 9DP3 9DP4	1U7B 1UL1 3Q8K 3Q8L 3Q8M 3UVU 5E0V 5FV7 5K97 5KSE 5UM9 5ZOD 5ZOE 5ZOF 5ZOG 6TNZ 7QO1 8YJH 8YJL 8YJQ 8YJR 8YJS 8YJU 8YJV 8YJW 8YJZ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Nucleoplasm Nucleic Acid Metabolic Process DNA Metabolic Process 5'-deoxyribose-5-phosphate Lyase Activity Protein-containing Complex DNA Damage Response Damaged DNA Binding Nuclear Telomere Cap Complex Macromolecule Metabolic Process Enzyme Binding Negative Regulation Of DNA Metabolic Process Cellular Response To Stress Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Telomere Maintenance Negative Regulation Of Metabolic Process DNA Binding Base-excision Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Negative Regulation Of RNA Metabolic Process Response To Stress Chromosome Organization Transcription Cis-regulatory Region Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Telomere Organization Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Double-stranded Telomeric DNA Binding DNA Repair Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Signaling Pathway Telomeric DNA Binding Regulation Of Cellular Response To Stress Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Biosynthetic Process Response To Radiation Chromosome, Telomeric Region Regulation Of Primary Metabolic Process Negative Regulation Of Telomere Maintenance Regulation Of Metabolic Process DNA Binding, Bending Protein-DNA Complex Double-strand Break Repair DNA Biosynthetic Process	Cellular Response To Stress Telomere Maintenance Telomere Organization Nucleic Acid Metabolic Process DNA Damage Response Response To Stress Macromolecule Metabolic Process Cellular Response To Radiation Chromosome, Telomeric Region DNA Damage Checkpoint Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Metabolic Process Chromosome Organization Nucleus DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Intracellular Signal Transduction Nucleoplasm Mitotic DNA Damage Checkpoint Signaling Checkpoint Clamp Complex Response To Radiation Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Cellular Response To Ionizing Radiation Positive Regulation Of DNA Metabolic Process Double-stranded DNA 3'-5' DNA Exonuclease Activity Regulation Of DNA Metabolic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Cell Cycle Telomeric D-loop Disassembly Negative Regulation Of Cell Cycle Phase Transition Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of DNA Replication Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Oxygen-containing Compound Telomeric Loop Disassembly T-circle Formation Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Macromolecule Metabolic Process Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process DNA Replication 3'-5' Exonuclease Activity Damaged DNA Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Forked DNA-dependent Helicase Activity
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