TNIP2 and TNFAIP3

Number of citations of the paper that reports this interaction (PMID 10385526)
54

Data Source:
HPRD (in vivo, two hybrid)

		TNIP2	TNFAIP3
Gene Name		TNFAIP3 interacting protein 2	tumor necrosis factor, alpha-induced protein 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Lysosome Centrosome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding Polyubiquitin Binding	Protease Binding DNA Binding Ubiquitin-protein Transferase Activity Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ligase Activity Kinase Binding Ubiquitin Binding Protein Self-association
	Biological Process	Transcription, DNA-templated Apoptotic Process Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Positive Regulation Of B Cell Activation Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process	B-1 B Cell Homeostasis Response To Molecule Of Bacterial Origin Regulation Of Germinal Center Formation Negative Regulation Of Chronic Inflammatory Response Proteolysis Apoptotic Process Inflammatory Response Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Toll-like Receptor 5 Signaling Pathway Protein K11-linked Deubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Bone Resorption Negative Regulation Of Innate Immune Response Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Defense Response To Virus By Host Negative Regulation Of Inflammatory Response Negative Regulation Of B Cell Activation Protein Oligomerization Regulation Of Vascular Wound Healing Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Deubiquitination Protein K48-linked Ubiquitination Protein K48-linked Deubiquitination Cellular Response To Lipopolysaccharide Tolerance Induction To Lipopolysaccharide Establishment Of Protein Localization To Vacuole Negative Regulation Of Osteoclast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Hepatocyte Proliferation Negative Regulation Of CD40 Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Innate Immune System
Drugs
Diseases
GWAS			Cardiac Troponin-T levels ( 23247143) Celiac disease ( 20190752) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190 19169254) Rheumatoid arthritis ( 20453841 20453842 17982456) Systemic lupus erythematosus ( 23273568 19165918 19838193) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		23 interactors: APP CDKN1A CHUK EP300 FBXO25 FLNA IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NFKB1 NFKB2 PDCD6IP PSMD9 REL RELA SMARCD1 SRPK2 STK11 TEK TNFAIP3 UBC	38 interactors: ARRDC3 CCDC50 CHUK GIT2 IKBKB IKBKG LAPTM5 OCLN RBCK1 RIPK1 RLIM RNF11 RNF14 RNF5 TAX1BP1 TICAM1 TNF TNIP1 TNIP2 TNIP3 TRAF1 TRAF2 TRAF6 TRIM2 TRIM23 TRIM3 TRIM5 TRIM8 UBC UBE2D1 UBE2N YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZFAND5
Entrez ID		79155	7128
HPRD ID		18207	01857
Ensembl ID		ENSG00000168884	ENSG00000118503
Uniprot IDs		D6RGJ2 Q8NFZ5	P21580
PDB IDs			2EQE 2EQF 2EQG 2VFJ 3DKB 3OJ3 3OJ4 3VUW 3VUX 3VUY 3ZJD 3ZJE 3ZJF 3ZJG
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Innate Immune Response Regulation Of Type I Interferon Production Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Immune System Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Apoptotic Process Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Programmed Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Death Death Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress I-kappaB Kinase/NF-kappaB Signaling Immune Response Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Defense Response Antigen Receptor-mediated Signaling Pathway Regulation Of Innate Immune Response Signal Transduction Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Gene Expression NIK/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Signaling Positive Regulation Of Cellular Biosynthetic Process	Positive Regulation Of NF-kappaB Transcription Factor Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 4 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Regulation Of Signaling Regulation Of Immune Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Defense Response Apoptotic Process I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Cell Death Death Positive Regulation Of Immune System Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Immune System Process Regulation Of Cell Death Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Intracellular Signal Transduction Cellular Response To Organic Substance
Tagcloud ?			125a 7e 99b arthritis clusters conversion depletion exacerbated il15 immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting upregulates upregulating upregulation whereby
Tagcloud (Difference) ?			125a 7e 99b arthritis clusters conversion depletion exacerbated il15 immunomodulatory inappropriate involve let micrornas mirna mirnas monocyte monocytes monocytic osteoclast p65 promoters proper rheumatoid shutting upregulates upregulating upregulation whereby
Tagcloud (Intersection) ?