TNIP2 and STK11

Number of citations of the paper that reports this interaction (PMID 12595760)
2

Data Source:
HPRD (two hybrid, in vitro)

		TNIP2	STK11
Gene Name		TNFAIP3 interacting protein 2	serine/threonine kinase 11
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Mitochondrion Cytosol Membrane TCR Signalosome Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Kinase Binding Polyubiquitin Binding	Magnesium Ion Binding P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding LRR Domain Binding Protein Kinase Activator Activity Protein Complex Binding
	Biological Process	Transcription, DNA-templated Apoptotic Process Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Positive Regulation Of B Cell Activation Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Energy Reserve Metabolic Process Protein Phosphorylation Autophagy Cellular Response To DNA Damage Stimulus Cell Cycle Arrest Spermatid Development Axonogenesis Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Response To Ionizing Radiation Establishment Of Cell Polarity Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Response To Glucagon Response To Lipid TCR Signalosome Assembly Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Anoikis Small Molecule Metabolic Process Positive Thymic T Cell Selection Positive Regulation Of Gluconeogenesis Protein Autophosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Protein Heterooligomerization Golgi Localization Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	Insulin receptor signalling cascade Integration of energy metabolism IRS-mediated signalling Regulation of AMPK activity via LKB1 mTOR signalling IRS-related events mTOR signalling IGF1R signaling cascade IRS-related events triggered by IGF1R IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Energy dependent regulation of mTOR by LKB1-AMPK AMPK inhibits chREBP transcriptional activation activity PKB-mediated events PI3K Cascade PKB-mediated events PI3K Cascade Signaling by Insulin receptor
Drugs
Diseases
GWAS			Alzheimer's disease ( 22005930)
Protein-Protein Interactions		23 interactors: APP CDKN1A CHUK EP300 FBXO25 FLNA IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NFKB1 NFKB2 PDCD6IP PSMD9 REL RELA SMARCD1 SRPK2 STK11 TEK TNFAIP3 UBC	29 interactors: APP ATM CAB39 CDC37 ETV4 MAPRE1 MARK1 MARK2 MARK4 MOB4 PARD3 PRKAA1 PRKAA2 PRKACA PTEN RPS6KA3 RPS6KA5 RPS6KB1 SIK1 SIRT1 SMARCA4 SNRK SPDEF STK11IP STRADA STRADB TNIP2 TP53 UBE2D2
Entrez ID		79155	6794
HPRD ID		18207	03740
Ensembl ID		ENSG00000168884	ENSG00000118046
Uniprot IDs		D6RGJ2 Q8NFZ5	Q15831
PDB IDs			2WTK
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Innate Immune Response Regulation Of Type I Interferon Production Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Immune System Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Apoptotic Process Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Programmed Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Death Death Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress I-kappaB Kinase/NF-kappaB Signaling Immune Response Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Defense Response Antigen Receptor-mediated Signaling Pathway Regulation Of Innate Immune Response Signal Transduction Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Gene Expression NIK/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Signaling Positive Regulation Of Cellular Biosynthetic Process	Regulation Of Cell Cycle Protein Phosphorylation Cell Cycle Cellular Protein Modification Process Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Protein Metabolic Process Cell Cycle Arrest Regulation Of Protein Metabolic Process Intracellular Signal Transduction Regulation Of Cell Death Histone Phosphorylation Regulation Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Phosphorylation Negative Regulation Of Cell Cycle Positive Regulation Of Cellular Protein Metabolic Process Phosphate-containing Compound Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Histone-serine Phosphorylation Cellular Response To Organic Substance Regulation Of Protein Kinase Activity Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Kinase Activity Insulin Receptor Signaling Pathway Protein Metabolic Process Cell Differentiation Signaling Response To Insulin Response To Peptide Hormone Cell Communication Response To External Stimulus Positive Regulation Of Protein Modification Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Response To Peptide Hormone Stimulus Response To Peptide Cellular Response To Peptide Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Regulation Of Signal Transduction
Tagcloud ?			alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue
Tagcloud (Difference) ?			alleles atm brca1 brca2 brip1 cdh1 chek2 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp suggestive suspicion unlikely venue
Tagcloud (Intersection) ?