TNIP2 and MAP3K8

Number of citations of the paper that reports this interaction (PMID 15169888)
23

Data Source:
HPRD (in vitro, in vivo)

		TNIP2	MAP3K8
Gene Name		TNFAIP3 interacting protein 2	mitogen-activated protein kinase kinase kinase 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding Polyubiquitin Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Transcription, DNA-templated Apoptotic Process Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Stabilization Positive Regulation Of B Cell Activation Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process	MAPK Cascade Activation Of MAPKK Activity Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Regulation Of Cell Differentiation
Pathways		Signaling by Interleukins Cytokine Signaling in Immune system Interleukin-1 signaling	Signaling by Interleukins Costimulation by the CD28 family CD28 co-stimulation CD28 dependent PI3K/Akt signaling Cytokine Signaling in Immune system Interleukin-1 signaling Adaptive Immune System
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		23 interactors: APP CDKN1A CHUK EP300 FBXO25 FLNA IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NFKB1 NFKB2 PDCD6IP PSMD9 REL RELA SMARCD1 SRPK2 STK11 TEK TNFAIP3 UBC	17 interactors: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		79155	1326
HPRD ID		18207	01863
Ensembl ID		ENSG00000168884	ENSG00000107968
Uniprot IDs		D6RGJ2 Q8NFZ5	P41279
PDB IDs
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Innate Immune Response Regulation Of Type I Interferon Production Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Immune System Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Apoptotic Process Activation Of Innate Immune Response Positive Regulation Of Type I Interferon Production Toll-like Receptor 4 Signaling Pathway Programmed Cell Death Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Death Death Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Toll-like Receptor Signaling Pathway T Cell Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress I-kappaB Kinase/NF-kappaB Signaling Immune Response Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Defense Response Antigen Receptor-mediated Signaling Pathway Regulation Of Innate Immune Response Signal Transduction Regulation Of Immune Response Positive Regulation Of Immune Response Positive Regulation Of Gene Expression NIK/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Signaling Positive Regulation Of Cellular Biosynthetic Process	Toll-like Receptor 3 Signaling Pathway Toll-like Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway NIK/NF-kappaB Signaling Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Signal Transduction Intracellular Signal Transduction Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Positive Regulation Of Cytokine Production Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Immune Response Positive Regulation Of Protein Serine/threonine Kinase Activity Response To Cytokine Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cytokine Production Response To Stress Positive Regulation Of Cellular Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity
Tagcloud ?			10r2 22r1 chorioallantoic cl41 controlling correlate erk helper il influences jb6 jnk jun knockdown mcf7 mediators mef mek mek1 microenvironment modulate pin1 promoting reactions secreted stat3 th17 tumorigenesis tumorigenicity
Tagcloud (Difference) ?			10r2 22r1 chorioallantoic cl41 controlling correlate erk helper il influences jb6 jnk jun knockdown mcf7 mediators mef mek mek1 microenvironment modulate pin1 promoting reactions secreted stat3 th17 tumorigenesis tumorigenicity
Tagcloud (Intersection) ?