TNIP2 and CLK1

Number of citations of the paper that reports this interaction (PubMedID 26167880)
0

Data Source:
BioGRID (enzymatic study)

		TNIP2	CLK1
Description		TNFAIP3 interacting protein 2	CDC like kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of B Cell Activation Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process	Regulation Of RNA Splicing
Pathways		MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases
Drugs			Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
Diseases
GWAS		Extrinsic epigenetic age acceleration ( 29374233) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 33536424)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		28 interacting genes: APP BACE1 CACNA1C CDKN1A CLK1 EP300 FBXO25 FLNA FXR2 IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NFKB1 NFKB2 PSMD9 REL RELA SHANK3 SMARCD1 SMURF1 SRPK2 STK11 TEK TNFAIP3 TSG101 UBC	170 interacting genes: ABCA13 ACOX2 ANKFY1 ARHGEF12 ARPC4 ASL ASXL3 ATP10A ATP4A BCLAF1 C1orf94 CDCP1 CDH23 CDK12 CELSR3 CENPE CEP95 CFAP20DC CFAP251 CKAP5 CLASRP CLK2 COCH CRNKL1 CTNND2 CUL3 CWC27 CYP46A1 DBR1 DDX23 DENND4A DNAJC13 DNAJC24 DOCK9 DPYD DSC2 DVL3 ECE1 ELP6 ENO1 ENTREP2 ERFE FAT1 FBF1 FHIP2B GEMIN5 GOLM1 GRM6 GSDMB H2BC12 HADH HIVEP1 HNMT HNRNPA0 HNRNPA1 HNRNPA3 HSP90AB2P HSPBP1 HTATSF1 ICE1 IMPDH2 IP6K1 ITGA5 KATNA1 KHDRBS1 KIF14 KIF23 KRT8 KRTAP10-6 KRTAP10-7 LINS1 LMNA LNX1 LUC7L3 MAP3K21 MAP7 MBP MFHAS1 MICU3 MKRN2 MTBP MTCL1 MTPAP MYOM1 NCL NCOR1 NF1 NPM1 NUP153 PATZ1 PDE9A PHF3 PHLDB2 PIAS4 PIGP PIP4K2B PKD1L1 PLAAT5 PLXDC2 PPFIBP2 PPHLN1 PPIG PPP1CB PRDX5 PRKDC PRMT5 PRP4K PRPF38A PRPF4 PTPN1 PTPN22 RAD21L1 RAPH1 RASL12 RBBP6 RBM15 RBMX REV1 RLF RPL5 RPS4Y1 RPUSD3 SAFB SAMD9L SCARA3 SERPINI2 SF3B1 SFMBT2 SH2B2 SHROOM1 SLC35D3 SLC75A1 SLFN5 SPEN SPTBN4 SRPK1 SRPK2 SRRM1 SRRM2 SRRM4 SRSF1 SRSF10 SRSF12 SRSF6 SRSF8 SSBP3 STIP1 STK31 SVOP TDRD9 TEX11 THRAP3 THY1 TJP2 TLN2 TMPO TMPRSS2 TNIP2 TP53RK TRA2B UBL5 UNC13B VWA7 YTHDC1 YWHAG ZC3H13 ZMYND10 ZNF148 ZNF830 ZRSR2
Entrez ID		79155	1195
HPRD ID		18207	09058
Ensembl ID		ENSG00000168884	ENSG00000013441
Uniprot IDs		D6RGJ2 Q8NFZ5	P49759
PDB IDs		5H07	1Z57 2VAG 5J1V 5J1W 5X8I 6FT8 6FT9 6FYO 6G33 6I5H 6I5I 6I5K 6I5L 6KHD 6Q8K 6Q8P 6QTY 6R3D 6R6E 6R6X 6R8J 6RAA 6TW2 6YTA 6YTD 6YTE 6YTG 6YTI 6Z4Z 6Z50 6ZLN 7AK3 7O9Y 7OA0 7OPG 8P04 8P08 8UWN
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Protein Metabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Primary Metabolic Process Cytosol NF-kappaB P50/p65 Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Inflammatory Response Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Protein Serine/threonine Kinase Binding Signal Transduction Response To UV-B Positive Regulation Of Cell Development Immune Response-regulating Cell Surface Receptor Signaling Pathway I-kappaB/NF-kappaB Complex Positive Regulation Of Defense Response Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cell Differentiation Nucleus Response To Lipopolysaccharide Negative Regulation Of MiRNA Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process NF-kappaB Complex Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Response To Molecule Of Bacterial Origin Response To Mechanical Stimulus Protein Serine Kinase Activity Response To Cytokine Regulation Of Immune System Process Regulation Of Gene Expression Response To Peptide Positive Regulation Of Neurogenesis	MRNA Processing RNA Splicing MRNA Metabolic Process RNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Regulation Of RNA Splicing RNA Metabolic Process RNA Binding Nuclear Speck Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Regulation Of MRNA Metabolic Process Spliceosomal Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Catalytic Step 2 Spliceosome Nucleoplasm Nucleic Acid Binding MRNA Splice Site Recognition Nucleus Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of RNA Splicing Negative Regulation Of RNA Splicing Protein-containing Complex Assembly Spliceosomal Complex Assembly Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Metabolic Process Protein-containing Complex Organization RS Domain Binding Spliceosomal SnRNP Assembly U2-type Precatalytic Spliceosome Nuclear Matrix Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity DNA Topoisomerase Binding
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