TNIP2 and GCH1

		TNIP2	GCH1
Description		TNFAIP3 interacting protein 2	GTP cyclohydrolase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein-containing Complex Neuron Projection Terminus
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Nucleotide Binding Catalytic Activity GTPase Activity GTP Cyclohydrolase I Activity Protein Binding GTP Binding Zinc Ion Binding Hydrolase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of B Cell Activation Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Regulation Of Blood Pressure Positive Regulation Of Heart Rate Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Type II Interferon Response To Tumor Necrosis Factor Dopamine Biosynthetic Process Pteridine-containing Compound Metabolic Process Pteridine-containing Compound Biosynthetic Process Tetrahydrobiopterin Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Removal Of Superoxide Radicals
Pathways		MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Guanine
Diseases			Primary torsion dystonia (PTD) Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Extrinsic epigenetic age acceleration ( 29374233) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 33536424)	Chronotype ( 30696823) Mercury levels ( 26025379) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 27182965 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 22446963) Serum metabolite levels ( 33031748)
Interacting Genes		28 interacting genes: APP BACE1 CACNA1C CDKN1A CLK1 EP300 FBXO25 FLNA FXR2 IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NFKB1 NFKB2 PSMD9 REL RELA SHANK3 SMARCD1 SMURF1 SRPK2 STK11 TEK TNFAIP3 TSG101 UBC	15 interacting genes: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 TNPO2 TNPO3 YWHAZ
Entrez ID		79155	2643
HPRD ID		18207	02573
Ensembl ID		ENSG00000168884	ENSG00000131979
Uniprot IDs		D6RGJ2 Q8NFZ5	P30793 Q8IZH9
PDB IDs		5H07	1FB1 6Z80 6Z85 6Z86 6Z87 6Z88 6Z89 7ALA 7ALB 7ALC 7ALQ
Enriched GO Terms of Interacting Partners?		Intracellular Signaling Cassette Canonical NF-kappaB Signal Transduction Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Immune System Process Regulation Of Protein Metabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Immune Response-activating Signaling Pathway Regulation Of Primary Metabolic Process Cytosol NF-kappaB P50/p65 Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Inflammatory Response Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Protein Serine/threonine Kinase Binding Signal Transduction Response To UV-B Positive Regulation Of Cell Development Immune Response-regulating Cell Surface Receptor Signaling Pathway I-kappaB/NF-kappaB Complex Positive Regulation Of Defense Response Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cell Differentiation Nucleus Response To Lipopolysaccharide Negative Regulation Of MiRNA Transcription Positive Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process NF-kappaB Complex Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Protein Kinase Activity Response To Molecule Of Bacterial Origin Response To Mechanical Stimulus Protein Serine Kinase Activity Response To Cytokine Regulation Of Immune System Process Regulation Of Gene Expression Response To Peptide Positive Regulation Of Neurogenesis	Establishment Of Localization In Cell GMP Binding Regulation Of Protein Stability Establishment Of Protein Localization Cellular Localization Extrinsic Component Of Synaptic Vesicle Membrane Protein Targeting Protein Kinase Binding ATPase Activator Activity Intracellular Protein Localization MHC Class II Protein Complex Binding Protein Transport Melanosome Protein-folding Chaperone Binding Unfolded Protein Binding Small GTPase Binding Nuclear Import Signal Receptor Activity Import Into Nucleus Intracellular Protein Transport Protein Folding Chaperone Complex Intracellular Transport GTP Cyclohydrolase I Regulator Activity GTP Cyclohydrolase Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Establishment Of Protein Localization To Organelle Exocrine System Development Type 1 Cannabinoid Receptor Binding ATP Metabolic Process Hsp90 Protein Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?