TMBIM6 and TNFRSF17

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMBIM6	TNFRSF17
Description		transmembrane BAX inhibitor motif containing 6	TNF receptor superfamily member 17
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Plasma Membrane Endomembrane System Membrane
	Molecular Function	Calcium Channel Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Immunoglobulin Production Autophagy Apoptotic Process Response To Unfolded Protein Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Signaling Pathway	Adaptive Immune Response Lymphocyte Homeostasis Immune System Process Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway
Pathways			TNFs bind their physiological receptors
Drugs			Belantamab mafodotin Teclistamab Idecabtagene vicleucel Ciltacabtagene autoleucel
Diseases
GWAS		General cognitive ability ( 29844566)	Blood protein levels ( 30072576) Phenylephrine infusion rate during anesthesia ( 31455332) QT interval ( 19305408) Testicular germ cell tumor ( 26503584)
Interacting Genes		66 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MMGT1 MS4A3 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC71A2 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A	8 interacting genes: CMTM7 PEX16 TMBIM6 TNFSF13 TNFSF13B TRAF1 TRAF2 TRAF3
Entrez ID		7009	608
HPRD ID		02851	00144
Ensembl ID		ENSG00000139644	ENSG00000048462
Uniprot IDs		P55061	Q02223
PDB IDs			1OQD 1XU2 2KN1 4ZFO 6J7W 8HXQ 8HXR 8QY9 8QYA 8QYB
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Dendritic Cell Apoptotic Process Endoplasmic Reticulum Membrane Connexin Complex Gap Junction Channel Activity Inorganic Ion Transmembrane Transport B Cell Receptor Complex Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transmembrane Transport Gap Junction Monoatomic Ion Transport BH3 Domain Binding SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Endoplasmic Reticulum Intercellular Transport	Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding Regulation Of Immunoglobulin Production Signaling Adaptor Activity Ubiquitin Protein Ligase Binding CD40 Receptor Complex Cytokine-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response Regulation Of DNA-binding Transcription Factor Activity Regulation Of Production Of Molecular Mediator Of Immune Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Cytokine Activity Positive Regulation Of Immune Response Positive Regulation Of B Cell Proliferation Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction TORC2 Complex Disassembly Regulation Of B Cell Proliferation Lymphocyte Homeostasis ER-dependent Peroxisome Organization ER-dependent Peroxisome Localization ABC-type Vitamin B12 Transporter Activity ATPase-coupled Lipid Transmembrane Transporter Activity Sphingolipid Transporter Activity Cell Death Apoptotic Process Endoribonuclease Inhibitor Activity Regulation Of Apoptotic Signaling Pathway Programmed Cell Death Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Immune Response Protein Phosphatase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Leukocyte Homeostasis Positive Regulation Of B Cell Activation Positive Regulation Of Germinal Center Formation Transitional One Stage B Cell Differentiation B-1a B Cell Differentiation Positive Regulation Of Immune System Process Signal Transduction Immune System Process Positive Regulation Of DNA-binding Transcription Factor Activity Ubiquitin Ligase Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?