TMBIM6 and OPRM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMBIM6	OPRM1
Description		transmembrane BAX inhibitor motif containing 6	opioid receptor mu 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Membrane Axon Dendrite Cell Projection Neuron Projection Perikaryon Synapse
	Molecular Function	Calcium Channel Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Beta-endorphin Receptor Activity G Protein-coupled Opioid Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding G Protein-coupled Peptide Receptor Activity G-protein Beta-subunit Binding Morphine Receptor Activity Neuropeptide Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Immunoglobulin Production Autophagy Apoptotic Process Response To Unfolded Protein Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Negative Regulation Of Cell Population Proliferation Sensory Perception Of Pain G Protein-coupled Opioid Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Morphine Regulation Of Cellular Response To Stress Regulation Of NMDA Receptor Activity
Pathways			Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling MECP2 regulates neuronal receptors and channels
Drugs			Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Meperidine Oxycodone Levallorphan Dextromethorphan Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Ketamine Levacetylmethadol Aripiprazole Methadyl acetate 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Epicept NP-1 LI-301 Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Methylnaltrexone Naloxegol Cannabidiol Trimebutine Butyrfentanyl Pholcodine Eluxadoline Tianeptine Opium Pentoxyverine Naldemedine Samidorphan Metenkefalin Medical Cannabis Nabiximols Loxicodegol Oliceridine
Diseases
GWAS		General cognitive ability ( 29844566)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Hypertension ( 21347282) Lipoprotein (a) levels ( 26377243) Menstruation quality of life impact (fever) ( 29855537) Methadone dose in opioid dependence ( 28115739) Nontraumatic osteonecrosis of the femoral head ( 32701715) Opioid use disorder ( 32492095) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		66 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MMGT1 MS4A3 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC71A2 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A	78 interacting genes: ADAM33 ADD3 ALOX5AP ATP6V0C ATP6V0E1 C2CD2L CALM1 CCDC167 CD302 CLCN7 CLDN10 CLDN22 CLDN8 CLEC12B CLEC7A CNIH1 COPS5 CPLX1 CTXN3 CYB561 DNAJB4 DOK4 DOK5 DRD2 EHHADH EMP1 EMP3 FLNA GJA4 GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 GRK3 GRM1 HS6ST1 IFITM3 KCNF1 LAT LPAR3 LRRC25 MAL MALL MAP1LC3A MAP1LC3C MFF NELFA NSG1 OPRD1 OPRL1 PLD2 PLD3 PMP22 PPL RPRM RTP4 SCGB1D1 SEC22A SERP2 SIAH1 SIAH2 SLC30A2 SLC38A7 SLC39A13 SLC41A1 SLC9A9 SMAGP TEX264 TM4SF4 TMBIM6 TMEM236 TRARG1 UBC VAPA WLS YIPF3 ZYX
Entrez ID		7009	4988
HPRD ID		02851	02484
Ensembl ID		ENSG00000139644	ENSG00000112038
Uniprot IDs		P55061	A0A6H0WF09 B8K2Q5 G8XRH4 G8XRH5 L0E130 P35372
PDB IDs			8EF5 8EF6 8EFB 8EFL 8EFO 8EFQ 8F7Q 8F7R 8K9K 8K9L 9MQH 9MQI 9MQJ
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Dendritic Cell Apoptotic Process Endoplasmic Reticulum Membrane Connexin Complex Gap Junction Channel Activity Inorganic Ion Transmembrane Transport B Cell Receptor Complex Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transmembrane Transport Gap Junction Monoatomic Ion Transport BH3 Domain Binding SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Endoplasmic Reticulum Intercellular Transport	Membrane Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Plasma Membrane Bleb Assembly Cytoplasmic Vesicle Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Protein Binding Intracellular Monoatomic Cation Homeostasis Heterotrimeric G-protein Complex Intracellular Monoatomic Ion Homeostasis G Protein-coupled Receptor Binding Lysosomal Membrane Monoatomic Cation Homeostasis G Protein-coupled Serotonin Receptor Binding Monoatomic Ion Homeostasis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Monoatomic Ion Transport Adenylate Cyclase Regulator Activity Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Monoatomic Cation Transport G Protein-coupled Dopamine Receptor Signaling Pathway Intracellular Chemical Homeostasis Transmembrane Transport Regulation Of Metal Ion Transport Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Monoatomic Ion Transport Endoplasmic Reticulum Membrane Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Bicellular Tight Junction Inorganic Ion Transmembrane Transport Phospholipase D Activity Cell-cell Signaling Membrane Raft Distribution G Protein-coupled Opioid Receptor Activity Anchoring Junction Monoatomic Ion Transmembrane Transport Chemical Synaptic Transmission Signaling Membrane Raft Localization Cellular Homeostasis Vesicle-mediated Transport Neuron-neuron Synaptic Transmission G Protein-coupled Opioid Receptor Signaling Pathway Proton-transporting V-type ATPase, V0 Domain Cell Communication
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