TMBIM6 and GJB4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMBIM6	GJB4
Description		transmembrane BAX inhibitor motif containing 6	gap junction protein beta 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Nucleoplasm Nucleolus Plasma Membrane Gap Junction Connexin Complex Membrane Cell Junction Anchoring Junction
	Molecular Function	Calcium Channel Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity	Gap Junction Channel Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Immunoglobulin Production Autophagy Apoptotic Process Response To Unfolded Protein Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Signaling Pathway	Cell Communication Cell-cell Signaling Sensory Perception Of Smell Olfactory Behavior Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways			Gap junction assembly
Drugs
Diseases			Erythrokeratodermia variabilis
GWAS		General cognitive ability ( 29844566)	Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		66 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MMGT1 MS4A3 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC71A2 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A	9 interacting genes: ARLN COMT KLRC1 LHFPL5 TM4SF4 TMBIM6 TMEM11 TMEM218 TMEM86A
Entrez ID		7009	127534
HPRD ID		02851	05666
Ensembl ID		ENSG00000139644	ENSG00000189433
Uniprot IDs		P55061	Q9NTQ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Dendritic Cell Apoptotic Process Endoplasmic Reticulum Membrane Connexin Complex Gap Junction Channel Activity Inorganic Ion Transmembrane Transport B Cell Receptor Complex Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transmembrane Transport Gap Junction Monoatomic Ion Transport BH3 Domain Binding SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Endoplasmic Reticulum Intercellular Transport
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