TMBIM6 and UGT2B11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMBIM6	UGT2B11
Description		transmembrane BAX inhibitor motif containing 6	UDP glucuronosyltransferase family 2 member B11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Calcium Channel Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity	Protein Binding UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Immunoglobulin Production Autophagy Apoptotic Process Response To Unfolded Protein Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Signaling Pathway	Xenobiotic Metabolic Process Estrogen Metabolic Process
Pathways			Glucuronidation Aspirin ADME
Drugs
Diseases
GWAS		General cognitive ability ( 29844566)	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Metabolite levels ( 23823483) Plasma clozapine-norclozapine ratio in treatment-resistant schizophrenia ( 30922102)
Interacting Genes		66 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MMGT1 MS4A3 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC71A2 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A	2 interacting genes: ASPH TMBIM6
Entrez ID		7009	10720
HPRD ID		02851	04345
Ensembl ID		ENSG00000139644	ENSG00000213759
Uniprot IDs		P55061	O75310
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Dendritic Cell Apoptotic Process Endoplasmic Reticulum Membrane Connexin Complex Gap Junction Channel Activity Inorganic Ion Transmembrane Transport B Cell Receptor Complex Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transmembrane Transport Gap Junction Monoatomic Ion Transport BH3 Domain Binding SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Endoplasmic Reticulum Intercellular Transport	Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-aspartic Acid 3-dioxygenase Activity Intracellular Calcium Ion Homeostasis Regulation Of Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Calcium Ion Transport Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Endoribonuclease Inhibitor Activity Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Activation Of Store-operated Calcium Channel Activity Intracellular Monoatomic Ion Homeostasis Regulation Of Metal Ion Transport Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Regulation Of Monoatomic Ion Transport Negative Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Store-operated Calcium Channel Activity Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Intracellular Chemical Homeostasis Regulation Of Cellular Localization Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Metal Ion Transport IRE1-mediated Unfolded Protein Response Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Cellular Homeostasis Negative Regulation Of Immunoglobulin Production Negative Regulation Of Cellular Response To Hypoxia Positive Regulation Of Calcium Ion Transport Into Cytosol Inorganic Ion Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Detection Of Calcium Ion Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Unfolded Protein Response To L-glutamate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Chemical Homeostasis Positive Regulation Of Cation Channel Activity
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