TMBIM6 and KCNC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMBIM6	KCNC1
Description		transmembrane BAX inhibitor motif containing 6	potassium voltage-gated channel subfamily C member 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Axon Dendrite Axolemma Neuron Projection Membrane Dendrite Membrane Neuronal Cell Body Membrane Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Axon Terminus Calyx Of Held Synapse Postsynaptic Membrane
	Molecular Function	Calcium Channel Activity Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding Endoribonuclease Inhibitor Activity	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Kinesin Binding Gated Channel Activity Transmembrane Transporter Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Immunoglobulin Production Autophagy Apoptotic Process Response To Unfolded Protein Negative Regulation Of Calcium Ion Transport Into Cytosol Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of RNA Splicing Cellular Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Calcium Ion Transmembrane Transport Response To L-glutamate Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Signaling Pathway	Action Potential Monoatomic Ion Transport Potassium Ion Transport Response To Toxic Substance Response To Light Intensity Response To Auditory Stimulus Response To Amine Cerebellum Development Optic Nerve Development Globus Pallidus Development Corpus Callosum Development Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Monoatomic Ion Transmembrane Transport Response To Potassium Ion Protein Homooligomerization Protein Tetramerization Transmembrane Transport Cellular Response To Xenobiotic Stimulus Response To Fibroblast Growth Factor Potassium Ion Transmembrane Transport Regulation Of Presynaptic Membrane Potential Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Transmembrane Transport Response To Nerve Growth Factor
Pathways			Voltage gated Potassium channels
Drugs			Enflurane Promethazine Miconazole Dalfampridine
Diseases
GWAS		General cognitive ability ( 29844566)	Body mass index ( 26426971) Night sleep phenotypes ( 27126917) Opioid sensitivity ( 24143882)
Interacting Genes		66 interacting genes: ADIPOR2 ATP13A1 BCL2 BCL2L1 CD300LG CD79A CD99L2 CDC7 CERS2 CLDN22 COBLL1 CREB3L1 EBP ENPP4 ERP29 ESAM FAM209A FERD3L FGFBP2 FXYD3 GJA5 GJA8 GJB4 GLP1R GPHB5 GPR151 GPR42 GPX8 GYPA GZMK HERPUD2 HJV HTR2C IER3 JSRP1 KCNA10 KCNC1 LIME1 LRRC59 MANBAL MMGT1 MS4A3 OPRM1 PI16 PIANP PVR REEP2 RHBDL2 SCN3B SIT1 SLAMF6 SLC12A7 SLC41A3 SLC71A2 SLC7A1 SOAT2 STEAP1B SYT9 TEX29 TMEM31 TMUB1 TMX2 TNFRSF17 TREML1 UGT2B11 VTI1A	7 interacting genes: ANK3 KCNG3 KCNH1 KCNV2 LPAR3 TMBIM6 TRARG1
Entrez ID		7009	3746
HPRD ID		02851	15936
Ensembl ID		ENSG00000139644	ENSG00000129159
Uniprot IDs		P55061	P48547
PDB IDs			7PHH 7PHI 7PHK 7PHL 7PQT 7PQU 8F1C 8F1D 8QUC 8QUD
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Transmembrane Transport Metal Ion Transport Monoatomic Cation Transport Dendritic Cell Apoptotic Process Endoplasmic Reticulum Membrane Connexin Complex Gap Junction Channel Activity Inorganic Ion Transmembrane Transport B Cell Receptor Complex Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Monoatomic Ion Transmembrane Transport Gap Junction Monoatomic Ion Transport BH3 Domain Binding SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Potassium Ion Transport Endoplasmic Reticulum Intercellular Transport	Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Regulation Of Metal Ion Transport Action Potential Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transport Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Metal Ion Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Biological Quality Plasma Membrane Inorganic Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Potassium Channel Regulator Activity Regulation Of Monoatomic Ion Transmembrane Transport Establishment Of Protein Localization To Plasma Membrane Monoatomic Ion Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Cation Transmembrane Transport Axon Negative Regulation Of Monoatomic Ion Transmembrane Transport Cyclic Nucleotide Binding Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Potassium Ion Transport Negative Regulation Of Monoatomic Ion Transport Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Endoribonuclease Inhibitor Activity Negative Regulation Of Transmembrane Transport Positive Regulation Of Cell Communication By Electrical Coupling Vesicle-mediated Transport To The Plasma Membrane Membrane Lysophosphatidic Acid Receptor Activity Regulation Of Transport Cellular Response To Metal Ion Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Calcium Ion Transport Into Cytosol Cellular Response To Magnesium Ion Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of IRE1-mediated Unfolded Protein Response Glucose Import In Response To Insulin Stimulus Protein Localization To Plasma Membrane
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